Human Tumour Xenografts in Anticancer Drug Development

Front Matter....Pages I-XV
Front Matter....Pages 1-1
The Therapeutic Response of a Variety of Human Tumour Xenografts....Pages 3-9
Biology of Human Ovarian Cancer Xenografts....Pages 11-13
Representativity of Xenografts for Clinical Cancer. Tumor and Host Characteristics as Variables of Tumor Take Rate....Pages 15-21
Front Matter....Pages 23-23
Comparison of Tumor Response in Nude Mice and in Patients....Pages 25-30
Front Matter....Pages 31-31
Conventional Agents in Human Ovarian Cancer Xenografts....Pages 33-35
Activity of Conventional Drugs in Head and Neck Cancer Xenografts....Pages 37-39
Preclinical Drug Evaluation with Human Melanoma Xenografts....Pages 41-46
Lung Xenografts as a Predictive Screen for Antineoplastic Agents....Pages 47-50
Chemotherapy Studies in Human Non-Small Cell Lung Cancer Xenografts Transplanted in Immune-Deprived Mice....Pages 51-55
Establishment and Response to Chemotherapy of Human Cervical Carcinoma Xenografts....Pages 57-62
The Usefulness of the Nude Mouse Model for Predicting the Chemosensitivity of Human Tumors. Studies in Malignant Melanoma....Pages 63-67
Front Matter....Pages 69-69
Screening of Analogs in Human Ovarian Cancer Xenografts....Pages 71-73
Predictability of Clinical Response of Several Human and Murine Tumor Models to Four Anthracycline Derivatives....Pages 75-78
Front Matter....Pages 79-79
Activity of Six New Drugs in Head and Neck Cancer Xenografts....Pages 81-83
Activity of Metallocene Complexes Against Human Tumours Heterotransplanted into Athymic Mice....Pages 85-88
Front Matter....Pages 89-89
The Effect of Human and Murine Interferons on Human Tumour Xenografts....Pages 91-94
Biodistribution and Therapeutic Efficacy of a Monoclonal Antibody-Methotrexate Conjugate in Mice....Pages 95-98
The Effect of Interferon-Alpha on the Activity of Cytotoxic Drugs in Bronchial Carcinoma Xenografts....Pages 99-102
The Nude Mouse for the Study of Immunotoxins....Pages 103-107
Front Matter....Pages 109-109
Proposal for the Application of Xenografts in Screening for New Anticancer Agents and in Selecting Tumor Types for Phase II Clinical Trials....Pages 111-114
Front Matter....Pages 109-109
Human Tumour Xenograft Models for Use with an In Vitro-Based, Disease-Oriented Antitumour Drug Screening Program....Pages 115-120
Front Matter....Pages 121-121
Mechanisms of Drug Resistance in Screening....Pages 123-126
Circumvention of Inherent Resistance with Verapamil in a Human Tumour Xenograft....Pages 127-130
Front Matter....Pages 131-131
Clonogenic Assay Screening Study Group (CASSG): Contribution to an EORTC Drug Screening Programme....Pages 133-133
Polyamine Uptake by Malignant Brain Tumour Xenografts in Nude Mice....Pages 134-134
The Activity for a Novel Niteosourea (TCNU) in Human Lung Cancer Xenografts....Pages 135-135
Xenografts in Pharmacologically Immunosuppressed Mice as a Model to Test the Chemotherapeutic Sensitivity of Human Tumours....Pages 135-136
New Tissue-Specific Metastasis Models in Adult Nude Mice....Pages 136-136
Fractionated Irradiation of Human Tumor Xenografts in Athymic Nude Mice....Pages 137-137
An Animal Model for Human Tumor Xenografts....Pages 137-138
Xenografted Human Tumors in Preclinical Drug Design....Pages 138-138
Growth in Nude Mice of a T-Cell Line from a Case of Acute Lymphoblastic Leukaemia: A Model for Experimental Immunotherapy of Human Neoplasia....Pages 139-139
5-Fluorouracil (5-FU) + Cis-diamminedichloroplatinum (DDP) Treatment of Human Colorectal Tumor Xenografts....Pages 140-140
Inter and Intra-Tumor Variation in the Response to Chemotherapy of Human Small Cell Carcinoma of the Lung (SCCL) Grown in Nude Mice....Pages 141-141
Human Carcinoma Cell Lines Xenografted in Athymic Mice: Biological and Antigenic Characterization of an Intra-Abdominal Model....Pages 141-142
Squamous Cell Carcinoma Xenografts as a Model for the Study of Drug-Induced Cell Kinetic Changes in Head and Neck Cancer....Pages 142-143