Human molecular biology : an introduction to the molecular basis of health and disease

Frontmatter......Page 1
Contents......Page 5
Preface......Page 21
Acknowledgements......Page 24
Read me first .........Page 25
Glossary......Page 27
Dedication......Page 33
Introduction: A disease for every gene?......Page 35
I - From molecular biology to human genetics......Page 39
1 - Biomolecular evolution......Page 41
2 - Chromatin and chromosomes......Page 81
3 - Gene expression......Page 109
4 - RNA processing and translation......Page 128
5 - Protein structure and function......Page 146
II - From molecular genetics to human biochemistry......Page 177
6 - Nutrition and energy......Page 179
7 - Membranes and channels......Page 205
8 - Cell-surface receptors and antigen recognition......Page 225
9 - Adhesion molecules and the extracellular matrix......Page 241
10 - Cytoskeletal proteins and molecular motors......Page 267
III - From molecular biochemistry to human cell biology......Page 283
11 - Signal transduction......Page 285
12 - Bioactive lipids and inflammatory cyotkines......Page 320
13 - Hormones and growth factors......Page 344
14 - Hemopoietins, angiogenins, and vasoactive mediators......Page 369
15 - Cell cycle control, apoptosis, and ageing......Page 388
IV - From molecular cell biology to human physiology......Page 421
16 - Development......Page 423
17 - Metabolism......Page 447
18 - Blood......Page 481
19 - Immunity......Page 505
20 - Neurobiology......Page 523
V - From molecular physiology to human molecular biology......Page 563
21 - Genetic experimental systems......Page 565
22 - Gene and protein analysis......Page 578
23 - Genetic engineering, gene mapping, and gene testing......Page 594
24 - Gene knockouts, transgenics, and cloning......Page 609
25 - Gene therapy and recombinant DNA technology......Page 619
Index......Page 635