Human Genetic Variation in Response to Medical and Environmental Agents: Pharmacogenetics and Ecogenetics

Front Matter....Pages I-VI
Pharmacogenetics and Ecogenetics....Pages 1-3
Front Matter....Pages 5-5
Multifactorial Inheritance and Heritability in Pharmacogenetics....Pages 7-11
Human Pharmacokinetics....Pages 13-17
Twin Studies in Pharmacogenetics....Pages 19-30
Search for Single Gene Effects in Multifactorial Inheritance in Pharmacogenetics....Pages 31-34
G6PD Variants....Pages 37-44
Pseudocholinesterase Variation....Pages 45-55
Aromatic Amines and Hydrazines, Drug Acetylation, and Lupus Erythematodes....Pages 57-63
Polymorphism of Human Serum Paraoxonase....Pages 65-68
Malignant Hyperthermia....Pages 69-70
Drug Sensitivity in Hereditary Hepatic Porphyria....Pages 71-78
Assets and Limitations of Animal Models....Pages 79-80
Psychopharmacogenetics....Pages 83-90
Alcohol and Alcoholism....Pages 91-100
Human Biochemical Genetics of Plasma Dopamine- β -Hydroxylase and Erythrocyte Catechol-O-Methyltransferase....Pages 101-112
Front Matter....Pages 113-113
Intestinal Lactase Polymorphisms and Dairy Foods....Pages 115-124
Genetic and Nongenetic Hyperlipidemia and Western Diets....Pages 125-130
Can Iron Fortification of Flour Cause Damage to Genetic Susceptibles (Idiopathic Haemochromatosis and β-Thalassaemia Major)?....Pages 131-138
Genetic Aspects of Induced Mutation....Pages 141-148
The Ah Locus: Aromatic Hydrocarbon Responsiveness... of Mice and Men....Pages 149-160
Front Matter....Pages 113-113
Aryl Hydrocarbon Hydroxylase in Man and Lung Cancer....Pages 161-168
An Overview of Animal and Microbial Test Systems for Carcinogenesis and Mutagenesis....Pages 169-176
A View From the U.S. President’s Science Advisory Office....Pages 179-184
Bioethical Problems in Pharmacogenetics and Ecogenetics....Pages 185-192
Back Matter....Pages 193-194