Human Auditory Development (Springer Handbook of Auditory Research, Vol. 43)

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
The Early History of Antibiotic Discovery: Empiricism Ruled....Pages 3-31
Rational Approaches to Antibacterial Discovery: Pre-Genomic Directed and Phenotypic Screening....Pages 33-75
Front Matter....Pages 77-77
Beta-Lactam Antibiotics....Pages 79-117
Review of the Quinolone Family....Pages 119-146
Tetracyclines....Pages 147-179
Macrolides and Ketolides....Pages 181-228
Aminoglycosides....Pages 229-269
Oxazolidinone Antibacterial Agents....Pages 271-299
Glycopeptides and Lipoglycopeptides....Pages 301-346
Front Matter....Pages 347-347
Efflux-Mediated Antimicrobial Resistance....Pages 349-395
Structural Mechanisms of β-Lactam Antibiotic Resistance in Penicillin-Binding Proteins....Pages 397-425
Evolution of β-Lactamases: Past, Present, and Future....Pages 427-453
Inducible Resistance to Macrolide Antibiotics....Pages 455-484
Fluoroquinolone Resistance: Mechanisms, Restrictive Dosing, and Anti-Mutant Screening Strategies for New Compounds....Pages 485-514
Glycopeptide Resistance....Pages 515-542
Acquired Tetracycline Resistance Genes....Pages 543-568
Front Matter....Pages 569-569
Evolution of Molecular Techniques for the Characterization of MRSA Clones....Pages 571-592
Mechanisms of Penicillin Resistance in Streptococcus pneumoniae : Targets, Gene Transfer and Mutations....Pages 593-616
Clinical Aspects of Multi-Drug Resistant Enterococci....Pages 617-648
Front Matter....Pages 649-649
Clinical Issues of Resistance: Problematic Microbes: Enterobacteriaceae....Pages 651-678
Front Matter....Pages 649-649
 Pseudomonas aeruginosa : A Persistent Pathogen in Cystic Fibrosis and Hospital-Associated Infections....Pages 679-715
Front Matter....Pages 717-717
Drug Resistant and Persistent Tuberculosis: Mechanisms and Drug Development....Pages 719-749
Front Matter....Pages 751-751
Resistance Trends and Susceptibility Profiles in the US Among Prevalent Clinical Pathogens: Lessons from Surveillance....Pages 753-792
Chemical Properties of Antimicrobials and Their Uniqueness....Pages 793-820
Natural Products in the 21st Century....Pages 821-847
Permeability of Bacteria to Antibacterial Agents....Pages 849-879
Novel Antibacterial Targets/Identification of New Targets by Comparative Genomics....Pages 881-900
Cell-Based Screening in Antibacterial Discovery....Pages 901-929
Enzyme-Based Screens in HTS....Pages 931-956
Antibacterial Inhibitors of the Essential Cell Division Protein FtsZ....Pages 957-968
Structure-Guided Discovery of New Antimicrobial Agents....Pages 969-984
NMR in Infection Research....Pages 985-1007
A Review of Animal Models Used for Antibiotic Evaluation....Pages 1009-1033
In Vivo Pharmacodynamic Modeling for Drug Discovery....Pages 1035-1054
Applications of Pharmacokinetic/Pharmacodynamic Models for the Development of Antimicrobial Agents....Pages 1055-1067
Front Matter....Pages 1069-1069
Antibiotic Drug Development: Moving Forward into the Clinic....Pages 1071-1100
Front Matter....Pages 1101-1101
Stimulating Antibacterial Research and Development: Sense and Sensibility?....Pages 1103-1105
Back Matter....Pages 1107-1127