Hughes Syndrome: Antiphospholipid Syndrome

Front Matter....Pages 1-1
Hughes Syndrome: History....Pages 3-8
Antiphospholipid (Hughes) Syndrome: An Overview....Pages 9-21
Epidemiology of Antiphospholipid Syndrome....Pages 22-28
Hemocytopenias in Antiphospholipid Syndrome....Pages 29-40
Cardiac Manifestations in Antiphospholipid Syndrome....Pages 41-52
Cerebral Ischemia in Antiphospholipid Syndrome....Pages 53-67
Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome....Pages 68-85
Skin Manifestations of Antiphospholipid Syndrome....Pages 86-98
Kidney Disease in Antiphospholipid Syndrome....Pages 99-111
Systemic Hypertension in Antiphospholipid Syndrome....Pages 112-116
Pulmonary Hypertension and Antiphospholipid Antibodies....Pages 117-126
Osteoarticular Manifestations of Antiphospholipid Syndrome....Pages 127-139
The Ear and Antiphospholipid Syndrome....Pages 140-146
The Eye in Primary Antiphospholipid Syndrome....Pages 147-154
Primary Antiphospholipid Syndrome....Pages 155-170
Catastrophic Antiphospholipid Syndrome....Pages 171-180
Obstetric Antiphospholipid Syndrome....Pages 181-195
Infertility and Antiphospholipid Antibodies....Pages 196-208
Transplantation of Solid Organs, Tissues, and Prosthetic Devices in Patients with Antiphospholipid Antibodies....Pages 209-240
Antiphospholipid Syndrome in Children....Pages 241-257
Front Matter....Pages 1-1
Ethnic and Geographic Variation in Antiphospholipid Syndrome....Pages 258-263
Antiphospholipid Syndrome: Differential Diagnosis....Pages 264-271
Front Matter....Pages 273-273
Anticardiolipin Testing....Pages 275-290
Lupus Anticoagulants: Mechanistic and Diagnostic Considerations....Pages 291-306
β 2 -glycoprotein I and Anti-β 2 -glycoprotein I Antibodies....Pages 307-318
Antiprothrombin Antibodies....Pages 319-328
Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies....Pages 329-337
Front Matter....Pages 339-339
Vascular Pathology of Antiphospholipid Antibody Syndrome....Pages 341-361
Placental Pathology in Antiphospholipid Syndrome....Pages 362-374
Antiphospholipid Syndrome — Experimental Models: Insight into Etiology, Pathogenesis, and Treatments....Pages 375-394
Antiphospholipid Antibody-Induced Pregnancy Loss and Thrombosis....Pages 395-402
Mechanism of Thrombosis in Antiphospholipid Syndrome: Binding to Platelets....Pages 403-414
Interaction of Antiphospholipid Antibodies with Endothelial Cells....Pages 415-426
The Influence of Antiphospholipid Antibodies on the Protein C Pathway....Pages 427-438
Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome....Pages 439-445
Annexins in Antiphospholipid Syndrome....Pages 446-456
Plasminogen Activation, Fibrinolysis, and Cell Proteolytic Activity in Antiphospholipid Syndrome....Pages 457-469
Lessons from Sequence Analysis of Monoclonal Antiphospholipid Antibodies....Pages 470-491
Apoptosis and Antiphospholipid Antibodies....Pages 492-500
Accelerated Atherogenesis and Antiphospholipid Antibodies....Pages 501-520
Front Matter....Pages 339-339
Genetics of Antiphospholipid Syndrome....Pages 521-531
Infection and Drug-Induced Antiphospholipid Antibodies....Pages 532-543
Front Matter....Pages 545-545
Management of Thrombosis in Antiphospholipid Syndrome....Pages 547-554
Management of Antiphospholipid Syndrome in Pregnancy....Pages 555-567
Management of Thrombocytopenia in Hughes Syndrome....Pages 568-578
The Future of Hughes Syndrome....Pages 579-582