Hormonal Carcinogenesis V

Contents......Page 12
Contributors......Page 21
Abbreviations......Page 32
SYMPOSIUM ADDRESS......Page 42
Relevance of the Concept of Oncogene Addiction to Hormonal Carcinogenesis and Molecular Targeting in Cancer Prevention and Therapy......Page 43
STATE OF THE ART SPEAKERS......Page 54
1. What Can we Learn about Breast Cancer from Stem Cells?......Page 55
2. Ovarian Cancer: Linking Genomics to New Target Discovery and Molecular Markers — The Way Ahead......Page 61
3. Cdk1, Plks, Auroras, and Neks: The Mitotic Bodyguards......Page 79
4. Women\'s Health Research: Perspectives from the National Institutes of Health......Page 95
Part 1: Cellular Origins of Endocrine-related Cancers......Page 105
5. Stem Cells, Hormones, and Mammary Cancer......Page 106
6. The Origin of Estrogen Receptor α-Positive and α-Negative Breast Cancer......Page 116
7. Hormone Refractory Prostate Cancer: Lessons Learned from the PTEN Prostate Cancer Model......Page 124
Part 2: Mitotic Kinases, Centrosome Amplification, and Genomic Instability......Page 133
8. Functional Significance of Aurora Kinase A in Centrosome Amplification and Genomic Instability......Page 134
9. Centrosome-Mediated Chromosomal Instability and Steroid Hormones as Co factors in Human Papillomavirus-Associated Cervical Carcinogenesis: Small Viruses Help to Answer Big Questions......Page 144
Part 3: New Developments in Steroid Receptor Interactions......Page 153
10. Regulation of Hormone Signaling by Nuclear Receptor Interacting Proteins......Page 154
11. Dynamics of Estrogen Receptor-mediated Transcriptional Activation of Responsive Genes In Vivo: Apprehending Transcription in Four Dimensions......Page 161
12. Expression of Estrogen Receptors α and β in Early Steps of Human Breast Carcinogenesis......Page 171
Part 4: Risk Assessment and Relevant Early Biomarkers......Page 181
13. Women\'s Health Initiative Studies of Postmenopausal Breast Cancer......Page 182
14. Circulating Levels of Sex Steroids and Prolactin in Premenopausal Women and Risk of Breast Cancer......Page 192
15. Ovulation and Ovarian Cancer......Page 201
16. Prostate Cancer Susceptibility Loci: Finding the Genes......Page 209
Part 5: Novel Strategies for Preventing and Treatment of Endocrine-related Cancers......Page 221
17. Strategy for the Application of Therapy in Prostate Cancer......Page 222
18. Response and Resistance to the Endocrine Prevention of Breast Cancer......Page 229
19. Estrogen-Induced Breast Oncogenesis: Modulation by an Aurora Kinase Inhibitor......Page 240
Part 6: Hormone Dependency Versus Hormone Independency......Page 248
20. Castration-Recurrent Prostate Cancer Is Not Androgen-Independent......Page 249
21. Estrogen-Receptor-Related Receptors and Hormone-Dependent Cancers......Page 261
22. Androgen Receptor Coactivators and Prostate Cancer......Page 270
Part 7: Emerging Fields: Hormones and Colorectal and Lung Cancers......Page 281
23. Why Hormones Protect Against Large Bowel Cancer: Old Ideas, New Evidence......Page 282
24. Vitamin D[sub(3)] and Colorectal Cancer......Page 293
25. Estrogen-Signaling Pathways in Lung Cancer......Page 303
COMMUNICATIONS......Page 312
Session I: Human Derived Studies......Page 313
Breast Cancer......Page 314
Noninvasive Measurement of the Electrical Properties of Breast Epithelium During the Menstrual Cycle: A Potential Biomarker for Breast Cancer Risk......Page 315
Is the Mannose-6-Phosphate/Insulin-Like Growth Factor 2 Receptor Coded by a Breast Cancer Suppressor Gene?......Page 323
Her-2/neu-induced \"Cytokine Signature\" in Breast Cancer......Page 329
Involvement of a JAK/STAT Pathway Inhibitor: Cytokine Inducible SH2 Containing Protein in Breast Cancer......Page 338
In Silico and In Vitro Analysis of Small Breast Epithelial Mucin as a Marker for Bone Marrow Micrometastasis in Breast Cancer......Page 347
Estrogen-regulated Cut-off Values of pS2 and Cathepsin D Expression in Breast Carcinomas......Page 356
Molecular Signatures of Estrogen Receptor-Associated Genes in Breast Cancer Predict Clinical Outcome......Page 364
Comparative Analysis of SNP in Estrogen-metabolizing Enzymes for Ovarian, Endometrial, and Breast Cancers in Novosibirsk, Russia......Page 373
IRF-1 Promotes Apoptosis in p53-damaged Basal-type Human Mammary Epithelial Cells: A Model for Early Basal-type Mammary Carcinogenesis......Page 381
Lung Cancer......Page 389
Steroid Receptor and Growth Factor Receptor Expression in Human Nonsmall Cell Lung Cancers Using Cells Procured by Laser-capture Microdissection......Page 390
Reproductive Endometrial Cancer......Page 398
Blood Levels of Organochlorine Pesticide Residues and Risk of Reproductive Tract Cancer Among Women from Jaipur, India......Page 399
Prostate Cancer......Page 407
AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer......Page 408
Session II: Cell/Molecular Biology and Hormone Metabolism......Page 417
Animal Models......Page 418
Expression of Selected Aurora A Kinase Substrates in Solely Estrogen-induced Ectopic Uterine Stem Cell Tumors in the Syrian Hamster Kidney......Page 419
Global Quantitative Analysis of Protein Phosphorylation Status in Fish Exposed to Microcystin......Page 427
Breast Cancer......Page 435
ERK/MAPK Regulation of the Androgen Responsiveness of Breast Cancer Cells......Page 436
Vascular Endothelial Growth Factor is a Target Gene for Estrogen Receptor and Contributes to Breast Cancer Progression......Page 443
Identification of Downstream Targets of Estrogen and c-myc in Breast Cancer Cells......Page 451
Cathepsin D Overexpressed by Cancer Cells Can Enhance Apoptosis-dependent Chemo-sensitivity Independently of Its Catalytic Activity......Page 458
A Synthetic Peptide Derived from Alpha-fetoprotein Inhibits the Estradiol-induced Proliferation of Mammary Tumor Cells in Culture through the Modulation of p21......Page 467
Hormonal Prevention of Breast Cancer: Significance of Promotional Environment......Page 473
Hormones of Pregnancy, α-Feto Protein, and Reduction of Breast Cancer Risk......Page 480
Role of Estrogens and Their Receptors in Adhesion and Invasiveness of Breast Cancer Cells......Page 488
Proteomic Analysis of Autocrine/Paracrine Effect sof Human Growth Hormone in Human Mammary Carcinoma Cells......Page 495
Endometrial Cancer......Page 503
Expression Analysis of Human Endometrial Adenocarcinoma in an Inbred Rat Model......Page 504
Amplification Studies of MET and Cdk6 in a Rat Endometrial Tumor Model and Their Correlation to Human Type I Endometrial Carcinoma Tumors......Page 511
Recurrent Chromosome 10 Aberrations and Tp53 Mutations in Rat Endometrial Adenocarcinomas......Page 518
Prostate Cancer......Page 525
Specific Properties of a C-terminal Truncated Androgen Receptor Detected in Hormone Refractory Prostate Cancer......Page 526
The Role of the Transcriptional Coactivator p300 in Prostate Cancer Progression......Page 532
Characterization of Androgen Regulation of ZEB-1 and PSA in 22RV1 Prostate Cancer Cells......Page 538
Mcl-1 is Regulated by IL-6 and Mediates the Survival Activity of the Cytokine in a Model of Late Stage Prostate Carcinoma......Page 544
Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment......Page 553
Inactivation of ID-1 Gene Induces Sensitivity of Prostate Cancer Cells to Chemotherapeutic Drugs......Page 561
Membrane Initiated Signaling by 1,25α-dihydroxyvitamin D[sub(3)] in LNCaP Prostate Cancer Cells......Page 569
Gonadotrophin Releasing Hormone-Based Vaccine, an Effective Candidate for Prostate Cancer and Other Hormone-sensitive Neoplasms......Page 576
Liver Cancer......Page 583
Pigment Epithelium-derived Factor is an Angiogenesis and Lipid Regulator that Activates Peroxisome Proliferator-activated Receptor α......Page 584
Hormone Metabolism......Page 591
Estrogenic Activity of the Equine Estrogen Metabolite, 4-Methoxyequilenin......Page 592
Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis......Page 599
Gene Expression of 17β-Estradiol-metabolizing Isozymes: Comparison of Normal Human Mammary Gland to Normal Human Liver and to Cultured Human Breast Adenocarcinoma Cells......Page 606
Phytoestrogens Modulate the Expression of 17α-Estradiol Metabolizing Enzymes in Cultured MCF-7 Cells......Page 614
A......Page 622
B......Page 624
C......Page 626
D......Page 629
E......Page 630
F......Page 633
H......Page 634
I......Page 635
L......Page 636
M......Page 637
N......Page 638
O......Page 639
P......Page 640
R......Page 643
S......Page 644
T......Page 645
W......Page 646
Z......Page 647