Hormonal Carcinogenesis: Proceedings of the First International Symposium

Front Matter....Pages i-xxxiv
Diethylstilbestrol (DES) Syndrome: Present Status of Animal and Human Studies....Pages 1-8
Front Matter....Pages 9-9
Introduction....Pages 11-17
The Conjoint Actions of Androgens and Estrogens in the Induction of Proliferative Lesions in the Rat Prostate....Pages 18-26
Enhancement of Prostate Carcinogenesis in Rats by Testosterone and Prolactin....Pages 27-32
Hormonal Carcinogenesis in Syrian Hamsters: A Hypothesis Involving Glutathione S-Transferase Regulation....Pages 33-40
Front Matter....Pages 41-41
Introduction....Pages 43-50
Control of Uterine Epithelial Growth and Differentiation: Implications for Estrogen-Associated Neoplasia....Pages 51-57
A Novel Protein Kinase Activity Identified from Human Breast Cancer Cell Lines....Pages 58-64
Estrous Cycle Modification of Rat Mammary Carcinoma Induction....Pages 65-72
Hormones, Cell Proliferation, and Mammary Carcinogenesis....Pages 73-77
Front Matter....Pages 79-79
Introduction....Pages 81-85
Interactions of Carcinogenic Estrogens with Microtubular Proteins....Pages 86-94
Differential Interactions of Estradiol Metabolites with the Estrogen Receptor: Genomic Consequences and Tumorigenesis....Pages 95-103
Oxidation of Estrogens and Other Steroids by Cytochrome P-450 Enzymes: Relevance to Tumorigenesis....Pages 104-109
Metabolism of Moxestrol in the Hamster Kidney: Significance for Estrogen Carcinogenesis....Pages 110-117
Front Matter....Pages 119-119
Introduction....Pages 121-123
Sexual Dimorphism of Hepatic Steroid Metabolism and Its Significance for Chemical Hepatocarcinogenesis....Pages 124-129
Growth Stimulation and Tumor Promotion in Rat Liver by Ethynyl Estradiol and Other Estrogens....Pages 130-137
Growth Factors in Murine Mammary Adenocarcinomas Induced by Progestins....Pages 138-144
The Influence of Steroid Hormones and Antihormones on the Growth and Differentiation of Normal Human Breast Cells in Culture....Pages 145-156
Front Matter....Pages 157-157
Introduction....Pages 159-163
The v- raf and Ha- ras Oncogenes Inhibit Transcription from the Beta-Casein Gene Promoter by Suppression of a Mammary Gland Specific Transcription Factor....Pages 164-171
Functional Aspects of EGF-Like Peptides in Ovarian-Steroid Responsive Organs....Pages 172-181
Androgen Regulation of Growth Factor and Early Growth Repsonse Gene Expression in Hamster DDT1-MF2 and Human Prostate LNCAP Cells....Pages 182-192
Estrogen Regulation of Protooncogene Expression....Pages 193-200
Front Matter....Pages 201-201
Introduction....Pages 203-208
Endogenous Estrogen and Progesterone as the Major Determinants of Breast Cancer Risk: Prospects for Control by ‘Natural’ and ‘Technological’ Means....Pages 209-216
Synthetic Estrogens and Liver Cancer: Risk Analysis of Animal and Human Data....Pages 217-224
Carcinogenic Risk Assessment of Steroid Hormone Exposure in Relation to Prostate Cancer Risk....Pages 225-233
Front Matter....Pages 235-235
Hormonal Carcinogenesis—Future Perspectives....Pages 237-244
Front Matter....Pages 245-245
Cytogenetic Changes in Renal Neoplasms and During Estrogen-Induced Renal Tumorigenesis in Hamsters....Pages 247-250
Pituitary Regulation of Sex-Differentiated Promotion of Rat Liver Carcinogenesis....Pages 251-253
Modulation of Estrogen Metabolism by Inducers of P-4501A2: Possible Application to the Chemoprevention of Breast Cancer....Pages 254-258
Estrogen Metabolism in Subcellular Preparations and Tissue Cultures of Syrian Hamster Liver and Kidney....Pages 259-262
Hormonal Regulation of Plasminogen Activation in the Human Endometrium....Pages 263-267
Your Research—Our Lives....Pages 268-271
Prostaglandin H Synthase Peroxidase Catalyzed Metabolism of Estrogens in Syrian Hamster and Rabbit Kidney....Pages 272-273
Peroxidative Metabolism of Diethylstilbestrol in Ram Seminal Vesicle Cell Cultures: An In Vitro Model for Studies of Estrogen-Induced Genotoxicity....Pages 274-276
 In Vivo Effects of Progesterone on Human Breast 17 β -Dehydrogenase and Epithelial Cells Mitotic Activities....Pages 277-279
DNA Adduct Profiles in Hamster Kidney Following Chronic Exposure to Various Carcinogenic and Noncarcinogenic Estrogens....Pages 280-284
Front Matter....Pages 245-245
Hormone-Dependent Activation of c-Ki- ras in N -Methyl- N -Nitrosourea (MNU)-Induced Mouse Mammary Tumors....Pages 285-287
Growth Hormone Regulation of the c- myc Gene During Sex-Differentiated Rat Liver Carcinogenesis....Pages 288-291
Fetal Stromal Cells Produce a TGF that Elicits Hyperplasia in Adult Mammary Epithelium....Pages 292-295
Induction of Catechol Estrogen Formation by Indole-3-Carbinol....Pages 296-299
Cytochrome P-450 Mediated Activation and Irreversible Binding of Tamoxifen to Rat and Human Liver Proteins....Pages 300-304
Neonatal Diethylstilbestrol Prevents Spontaneously Developing Mammary Tumors....Pages 305-308
Hormone-Dependent Uterine Adenocarcinoma Following Developmental Treatment with Diethylstilbestrol: A Murine Model for Hormonal Carcinogenesis....Pages 309-312
Effects of Steroidal and Stilbene Estrogens and Their Peroxidative Metabolites on Microtubular Proteins....Pages 313-317
Properties of Micronuclei Induced by Various Estrogens in Two Different Mammalian Cell Systems....Pages 318-322
High-Performance Liquid Chromatography Method for the Separation of Potential Metabolites of Estradiol....Pages 323-325
Ovarian Hormones Enhance the Carcinogenic Activity of 2,3,7,8-TCDD in Rats....Pages 326-329
Back Matter....Pages 331-340