Hormonal Carcinogenesis IV

Cover Page......Page 1
Half-Title......Page 2
Inside Cover......Page 4
Copyright......Page 5
Dedication......Page 6
Acknowledgements......Page 7
Executive and Scientific Advisory Boards......Page 8
Preface......Page 10
Contents......Page 11
Participants......Page 20
Symposium Address: Hormones, Centrosomes, and Genomic Instability in Mammary Carcinogenesis......Page 28
STATE OF THE ART LECTURES......Page 44
1. Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis......Page 46
2. The Molecular Pathogenesis of Human Prostate Cancer......Page 61
PART 1. BREAST CANCER I: PROGESTERONE ACTION......Page 72
3. Pathologic, Clinical, and Epidemiologic Characteristics of Invasive Lobular Breast Carcinoma and a Review of Studies Evaluating its Association with Hormone Replacement Therapy......Page 74
4. Progestin-Regulated Genes and Breast Cancer Risk: Good or Bad?......Page 92
5. Role of Progesterone Receptors in Mammary Development and Carcinogenesis......Page 104
PART 2. BREAST CANCER II: MECHANISMS OF GENOMIC INSTABILITY......Page 112
6. c-Myc Deregulation Promotes a Complex Network of Genomic Instability......Page 114
7. Deregulation of Cyclin E and Genomic Instability......Page 125
8. Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer......Page 133
PART 3. BREAST AND PROSTATE: EARLY IN-SITU LESIONS......Page 146
9. Premalignant Breast Disease: Anatomic Lesions and Hormonal Associations......Page 148
10. Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice......Page 157
11. Prostate Epithelial Carcinogenesis: Putative and Controversial Precursor Lesions......Page 168
PART 4. PROMOTION/PREVENTION OF HORMONE CANCERS......Page 178
12. Estrogen Can Prevent Breast Cancer by Mimicking the Protective Effect of Pregnancy......Page 180
13. Aromatase Inhibition and Breast Cancer......Page 193
PART 5. PROSTATE I: ANDROGEN/ESTROGEN ACTION......Page 208
14. Androgens and Prostate Cancer Etiology: Sorting Through the Evidence......Page 210
15. Id-1 Protein as a New Marker for PCA......Page 224
PART 6. PROSTATE II: ANDROGEN RECEPTOR: DEPENDENCE/RESISTANCE......Page 236
16. Four Stages of Prostate Cancer: Suppression and Eradication by Androgen and Green Tea Epigallocatechin Gallate......Page 238
17. Androgen Receptor and Interleukin-6 Signaling In PCA Progression......Page 248
18. Role of the Androgen Receptor and PI3K/Akt in the Survival of Androgen-Refractory Prostate Cancer Cells......Page 260
PART 7. ENDOMETRIUM/OVARIAN/COLON......Page 272
19. The BDII Inbred Rat: A Model for Genetic Analysis of Endometrial Carcinoma......Page 274
20. Potential Role of Gonadotropin-Releasing Hormone and Estrogen in Ovarian Cancer......Page 285
Epidemiology......Page 298
Dose of Progestogen in Postmenopausal Combined Hormone Therapy and Risk of Endometrial Cancer......Page 300
Mammographic Densities and Urinary Hormones in Healthy Women with Different Ethnic Backgrounds......Page 304
Polymorphism of the Estrogen Receptor-beta Gene in Breast Cancer......Page 314
Characterization of Genetic Polymorphism of Glycine N-Methyltransferase Gene in Hepatocellular Carcinoma......Page 320
Role of Soy Phytoestrogens Genistein and Daidzein in Focal Adhesion Assembly and Focal Adhesion Kinase Activity in Breast Cancer Cells......Page 327
Identification of Genes Regulated by the Antiprogestin, Onapristone, in Breast Cancer Cells using Microarray Analysis......Page 335
Expression of Estrogen and Variants, Androgen, and Progesterone Receptors in Human Normal and Neoplastic Endometrium......Page 341
Toremifene (ACAPODENE™) Reduces High Grade Prostatic Intraepithelial Neoplasis in a Phase II a Clinical Trial......Page 348
Stereological Study of Mean Nuclear Volume Weighted by Volume in Normal Prostate, Prostatic Intraepithelial Neoplasia, and Adenocarcinoma......Page 356
Constitutively Active Androgen Receptor Variant Detected in a Human Prostate Cancer......Page 363
Cancer Prevention by Green Tea via EGCG-Mediated Inhibition of Fatty Acid Synthase......Page 370
Silencing of the Fatty Acid Synthase Gene by RNA Interference Inhibits Growth and Induces Apoptosis of LNCaP Prostate Cancer Cells......Page 377
Androgens Stimulate the SREBP Pathway in Prostate Cancer Cells by Inducing a Shift in the SCAP-Retention Protein(s) Balance......Page 384
Session II. Hormone Metabolism and Cell/Molecular Biology......Page 392
Metabolism of 17beta-Estradiol in ACI Rat Liver and Mammary Gland After Chronic Estradiol Treatment......Page 394
Modulation of Transforming and Clastogenic Activities of Catechol Estrogens by a Catechol-O-methyltransferase Inhibitor in Syrian Hamster Embryo Fibroblasts......Page 402
Bi-directional Regulation of Human Progesterone Receptors and the Mitogen Activated Protein Kinase Pathway in Breast Cancer Cell Models......Page 408
Abnormal Properties of Mutants in the Hinge Region of ERalpha: Implications in Breast Cancer......Page 418
The Effects of Eicosapentaenoic Acid Upon Proliferation and 17beta-Dehydrogenase Activity in MCF-7 Breast Carcinoma Cells......Page 425
Effect of Dietary Genistein on Estradiol-induced Mammary Carcinogenesis in the ACI Rat......Page 432
Cytogenetic Analysis of Genomic Destabilization in Solely Estrogen-Induced Female ACI Rat Mammary Neoplasms......Page 439
Microarray Analysis of Estrogeninduced Protection Against Breast Cancer......Page 446
Pregnancy Level of Estrogen Prevents Mammary Cancers......Page 453
Hormonal Dependence of Mammary Premalignant Progression......Page 458
The Possible Role of IGF-I and Androgens in the Development of Canine Inflammatory Mammary Carcinoma......Page 463
Hormonal Activation of the Gab-1 Docking Protein in Uterine Cells......Page 470
Endometrial Adenocarcinoma in Syrian Hamsters Treated with Diethylstilbestrol, Tamoxifen and N-Ethyl-Nitrosourea......Page 477
Hormonal Regulation of ZEB-1 and Implication for Progression of Human Reproductive Cancers......Page 482
Evaluation of Messenger RNA of Pituitary Tumour-transforming Gene-1 (PTTG1) as a Molecular Marker for Micrometastasis......Page 489
Presence of CCK-B Receptor mRNA in Human Functionless Pituitary Tumors......Page 495
Estrogen-Induced Mutations and Its Role in the Development of Tumorigenesis......Page 502
Englitazone Delays Fetal Growth in Late Gestation in the Rat......Page 507
The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines......Page 514
The Coactivators CBP and p300 in Androgen Independent Prostate Cancer......Page 521
Expression Study of Estrogen Receptor-related Receptors and Steroid Hormone Receptors in Human Prostatic Cells......Page 528
Immunohistochemical and In-Situ Detection of Sex Hormone-binding Globulin (SHBG)Expression in Breast and Prostate Cancer: Implications for Hormone Regulation......Page 535
Activation of Androgen Receptor in Prostate Cancer: Role of Protein Kinase A and Extracellular Signal-regulated Kinases......Page 542
Cadmium and Zinc Chloride-induced Preneoplastic Changes in the Rat Ventral Prostate: An Immunohistochemical and Molecular Study......Page 549
Index......Page 556