Hormonal Carcinogenesis III: Proceedings of the Third International Symposium

Front Matter....Pages i-xliii
Symposium Address....Pages 1-22
Front Matter....Pages 23-23
The Numbers Game with Estrogen Receptors and Growth Regulation....Pages 25-36
Expression Genetics of Hormone Dependent Human Tumors....Pages 37-43
New Directions in Epidemiologic Studies of Hormonally-related Cancers....Pages 44-58
Front Matter....Pages 59-59
Estrogen Causes Breast Cancer: Increasing Duration of Use of Postmenopausal Hormones Increases the Risk of Breast Cancer....Pages 61-69
Frequency of BRCA2 Mutations in Women with Early Onset Breast Cancer Drawn from a Population-Based Study....Pages 70-86
Prostate Cancer, Androgens, and Estrogens....Pages 87-96
Front Matter....Pages 97-97
Introduction....Pages 99-102
Genome Scanning and Tissue Microarrays for the Analysis of Molecular Mechanisms Underlying Hormone Therapy Failure in Prostate Cancer....Pages 103-112
Serial Analysis of Gene Expression in Breast Cancer Cells....Pages 113-123
The Effects of Triphenylethylene Antiestrogens on Parameters of Multistage Hepatocarcinogenesis in the Rat....Pages 124-135
Front Matter....Pages 137-137
Introduction....Pages 139-143
Estrogen Receptor-ß: An Important Player in Estrogen Action....Pages 144-148
Estrogen Receptor-mediated Genomic Instability in the Syrian Hamster Kidney: A Critical Event in Hormonal Oncogenesis....Pages 149-157
Front Matter....Pages 159-159
Introduction....Pages 161-165
The Dual Role of Estrogens and Cathepsin D in Invasion and Metastasis....Pages 166-177
Estrogen-induced Breast Cancer in Female ACI Rats....Pages 178-188
A Transgenic Mouse Model for Mammary Carcinogenesis....Pages 189-197
Front Matter....Pages 199-199
Introduction....Pages 201-205
Transcriptional Control of Cell Cycle Progression by Estrogenic Hormones: Regulation of Human Cyclin D1 Gene Promoter Activity by Estrogen Receptor-a....Pages 206-219
Front Matter....Pages 199-199
Estrogen Regulation of Cell Cycle Progression....Pages 220-227
Front Matter....Pages 229-229
Estrogen and c- myc Protooncogene Actions in Human Breast Cancer....Pages 231-237
Steroid Hormone Regulation of Vascular Endothelial Growth Factor (VEGF) Production: A Potential Step in Hormonal Carcinogenesis....Pages 238-249
A TGF- β /Estrogen-inducible Early Gene (TIEG): A Candidate Tumor Suppressor or Cell Cycle Regulator....Pages 250-260
Front Matter....Pages 261-261
Introduction....Pages 263-266
Control of Estrogen Biosynthesis in Breast Cancer....Pages 267-276
Regulation of Aromatase in Normal and Malignant Breast Tissues: The Role of the Immune System....Pages 277-284
Regulation of Aromatase in Breast Cancer and Correlation of Aromatase and Cyclooxygenase Gene Expression....Pages 285-298
Front Matter....Pages 299-299
Introduction....Pages 301-306
Etiologic Mechanisms in Epithelial Ovarian Cancer....Pages 307-319
Stromal Influences in Prostatic Carcinogenesis....Pages 320-332
Androgen Receptor Structure and Function in Prostate Cancer....Pages 333-341
Front Matter....Pages 343-343
Introduction....Pages 345-347
Role of Estrogen and Bone Morphogentic Protein Signaling in Osteoblast Differentiation....Pages 348-356
Estrogen and the Skeleton....Pages 357-362
Front Matter....Pages 363-363
Mechanisms of Estrogen Action on the Cardiovascular System....Pages 365-371
Atherosclerosis and Hormone Replacement Therapy: The Role of Estrogen in Secondary Prevention of Cardiovascular Events....Pages 372-382
Front Matter....Pages 385-385
Long-term Hormone Replacement Therapy: A Contrary Point of View....Pages 385-399
Front Matter....Pages 401-401
A Unified General Mechanism for Hormonal Carcinogenesis Begins to Emerge....Pages 403-405
Front Matter....Pages 407-407
The Risk of Post-menopausal Breast Cancer After Estrogen and Estrogen-Progestin Replacement....Pages 409-412
Front Matter....Pages 407-407
No Significant Difference in Age at Menarche, Menstrual Cycle Length, Age at First Full-Term Pregnancy, and Nulliparity Among BRCA1 Mutation Carriers Compared with Their Unaffected Relatives....Pages 413-417
Cell Proliferation and Apoptosis in the Normal Breast Epithelium of Pre, Peri, and Postmenopausal Women....Pages 418-423
Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells....Pages 424-428
Novel Small Molecule IL-6 Inhibitors as Anti-Cancer Drugs....Pages 429-434
Front Matter....Pages 435-435
Cellular Transforming Activity and Genotoxic Effects of 17β- Estradiol and its Eight Metabolites in Syrian Hamster Embryo Cells....Pages 437-443
Evidence for an Initiation Mechanism of 17β-Estradiol Carcinogenesis....Pages 444-450
Estradiol Metabolism by Rat Liver Microsomes from Strains Differing in Susceptibility to Mammary Carcinogenesis....Pages 451-455
Induction of Breast Cancer in Noble Rats Treated with a Combination of Estrogen and Testosterone....Pages 456-463
Isolation and Purification of Breast Carcinoma Cell Lines From a Noble Rat....Pages 464-470
The ACI Rat as a Genetically Defined Animal Model for the Study of Estrogen Induced Mammary Cancers....Pages 471-476
Characteristics of Dehydroepiandrosterone-induced Hepatocarcinogenesis in the Rat....Pages 477-483
Hepatic Toxicity of Estrogen in Armenian and Chinese Hamsters....Pages 484-488
Suppression of Liver Tumor Formation by the Liver Microenvironment of Female, but Not Male, Syngeneic Hosts....Pages 489-495
Dietary Energy Restriction Inhibits Estrogen Induced Pituitary Tumorigenesis in a Rat Strain Specific Manner....Pages 496-501
Estrogen-induced Prolactinoma Development: A Role for Cell-Cell Communication....Pages 502-508
Combined Administration of Transplacental Ethylnitrosourea and Postnatal Diethylstilbestrol Induces Neural Differentiation in Interstitial Cells of the Golden Hamster Kidney....Pages 509-513
Aromatase Overexpression: Is Aromatase an Oncogene....Pages 514-520
Genetic Toxicity In Vitro of Bisphenol A-Diglycidylether (BADGE) and its Hydrolysis Products....Pages 521-526
Lack of Genotoxicity of Major Mammalian and Plant Lignans at Various Endpoints In Vitro....Pages 527-532
Back Matter....Pages 533-555