Hormonal Carcinogenesis II: Proceedings of the Second International Symposium

Front Matter....Pages i-xl
Introductory Remarks....Pages 1-1
Opening Address....Pages 2-10
Symposium Presentation....Pages 11-27
Symposium Presentation....Pages 28-45
Front Matter....Pages 47-47
Cell Cycle Control....Pages 48-58
A Cell Cycle Regulator and Cancer....Pages 59-67
Molecular Cytogenetics of Solid Tumor Progression....Pages 68-78
Nucleocytoplasmic Shuttling of Estrogen Receptors is Blocked by “Pure Anti-Estrogens”....Pages 79-85
Front Matter....Pages 87-87
Introduction....Pages 88-90
Breast Cancer Incidence in Women Exposed to Estrogen and Estrogen-Progestin Replacement Therapy....Pages 91-98
Breast Cancer Trends in Women in Sweden, the UK, and the USA in Relation to Their Past Use of Oral Contraceptives....Pages 99-106
Gene Expression in Familial Breast Cancer: A Genetic-Epidemiologic Study of Premenopausal Bilateral Breast Cancer....Pages 107-112
Front Matter....Pages 113-113
Introduction....Pages 115-119
Breast Susceptibility to Carcinogenesis....Pages 120-131
Hormones, Growth Factors, and Gene Expression in Preneoplasias of the Mouse Mammary Gland....Pages 132-140
Pathogenesis of Ductal and Lobular Progestin-Induced Mammary Carcinomas in BALB/c Mice....Pages 141-147
Front Matter....Pages 149-149
Is the hsp90 Connection Between Steroid Receptors and Immunosuppressant Binding Immunophilins Involved in the Control of Gene Transcription and Cell Growth?....Pages 150-155
Expression and Regulation of 17ß-Hydroxysteroid Dehydrogenase Type 1 in Steroidogenic Cells and Estrogen Target Tissues....Pages 156-166
Growth Factors in Endometrial Cancer....Pages 167-175
Front Matter....Pages 177-177
Introduction....Pages 178-184
Front Matter....Pages 177-177
Interstitial Cell Origin of Estrogen-Induced Kidney Tumors in the Syrian Golden Hamster....Pages 185-192
Effects of Estrogens on Microtubule Assembly: Significance for Aneuploidy....Pages 193-199
Estrogen Carcinogenesis: A Sequential, Epi-Genotoxic, Multi-Stage Process....Pages 200-208
Front Matter....Pages 209-209
Introduction....Pages 211-218
Hormonal Regulation of Hepatic Cell Proliferation and Apoptosis: Implications for Carcinogenesis....Pages 219-227
Mechanisms of Tamoxifen-Induced Genotoxicity and Carcinogenicity....Pages 228-239
Regulation of Growth-Associated Nuclear Transcription Factors During Growth Hormone-Regulated, Sex-Differentiated Rat Liver Carcinogenesis....Pages 240-249
Front Matter....Pages 251-251
Isolation of Differentially Expressed cDNAs from Prostate Cancer Cell Lines Using Differential Display PCR: Identification of an Androgen-Regulated Gene....Pages 252-259
Progression of LNCaP Human Prostate Carcinoma Cells: Androgen Receptor Activity and c-myc Gene Expression....Pages 260-268
Regulation of Prostate Growth and Gene Expression: Role of Stroma....Pages 269-277
Front Matter....Pages 279-279
Sex Hormones and Neoplastic Transformation....Pages 280-282
Front Matter....Pages 283-283
Introduction....Pages 285-286
Postmenopausal Estrogen-Progestin Therapy in Relation To Cancers of the Endometrium and Breast....Pages 287-294
The Use of Hormone Replacement Therapy in Women Previously Treated for Breast Cancer....Pages 295-298
Cardioprotection by Hormone Replacement Therapy....Pages 299-311
Risks and Benefits of Oral Contraceptives....Pages 312-320
Oral Contraceptives and the Risk of Breast and Cervical Cancer....Pages 321-328
Front Matter....Pages 329-329
Some Aspects of Breast Cancer Epidemiology....Pages 331-333
Risk of Breast Cancer Associated with Induced Abortion....Pages 334-339
Family History of Breast Cancer as a Modifier of Other Risk Factors....Pages 340-344
Front Matter....Pages 329-329
Oral Contraceptive Use and Reproductive Risk Factors for Breast Cancer: A Comparison of Results among Black and White Women....Pages 345-349
Patterns of Cancer Mortality in Women Who Had Used Sex Steroid Hormones Under Age 60....Pages 350-355
Progestogen Use and Risk of Breast Cancer....Pages 356-359
Five-Year Survival of Women with Breast Cancer According to Prior Use of Oral Contraceptives....Pages 360-364
Plasma Prolactin and IGF-1 Levels in Young, Healthy, Nulliparous Women in Relation to Low Dose Oral Contraceptive Use....Pages 365-369
Effect of a Low-Fat Diet on Estrogen and Bile Acid Metabolism in Normal Human Subjects....Pages 370-374
Expression of GSTπ in Breast Cancer and Its Relationship to the Expression of Estrogen and Progesterone Receptor....Pages 375-377
p53 and Neu (c- erb B-2) Overexpression in Relation to Risk Factors for Breast Cancer....Pages 378-382
Cost Effectiveness of Hormone Replacement Therapy in French Postmenopausal Women....Pages 383-385
Tamoxifen Treatment Does Not Induce Endometrial Hyperplasia in Postmenopausal Women....Pages 386-389
Uterine Leiomyomas: A Model to Study Hormonal Regulation of Growth Related Genes....Pages 390-393
Transforming Growth Factor ß1 Facilitates Cell Proliferation and Invasion in MAT-LyLu Prostatic Cancer Cells....Pages 394-397
Quantitative Effects of Antiandrogen Therapy on High-Grade Prostatic Intraepithelial Neoplasia in Radical Prostatectomy Specimens....Pages 398-403
Alterations in Circulating Levels of Androgens and PSA During Treatment with Finasteride in Men at High Risk for Prostate Cancer....Pages 404-407
Effect of Estradiol on MCF-7 Human Breast Cancer Cells: Ultrastructural Studies....Pages 410-413
Estradiol and Tamoxifen Induce TGF-β1 Gene Expression In Cultured Normal Human Breast Stromal Cells....Pages 414-417
Estrogen and Anti-Estrogen Regulation of Amplified erb B2 Gene Expression in Human Breast Cancer Cells....Pages 418-423
Evaluation of Conformational Changes in hER-HBD by Pharmacological Dissection of Hormone Dissociation Rates in a Homogeneous Hormone-Binding Assay....Pages 424-428
Estradiol Promotion of Size and Number of Hepatic Enzyme-Altered Foci in Rats in the Absence of Cell Proliferation....Pages 429-433
Expression of Liver-Enriched Transcription Factors During Progression in the Resistant-Hepatocyte Model....Pages 434-437
Front Matter....Pages 329-329
Nuclear Protein Binding to the AP-1 and CRE Sites During Sex-Differentiated Promotion of Rat Liver Carcinogenesis....Pages 438-441
Induction of Endometrial Cancer by Tamoxifen in the Rat....Pages 442-445
Mechanisms of Anti-Estrogen and Retinoid Inhibition of Breast Cancer Cell Proliferation....Pages 446-449
Bisphenol-A Disturbs Microtubule Assembly and Induces Micronuclei In Vitro ....Pages 450-453
Natural Estrogens Induce Modulation of Microtubules in Chinese Hamster V79 Cells in Culture....Pages 454-457
Induction of Micronucleation, Spindle Disturbances, and Mitotic Arrest in Human Chorionic Villi Cells by 17ß-Estradiol, Diethylstilbestrol, and Coumestrol....Pages 458-462
Increased Nuclear IGF-1 Receptor Level, Coupled with Attenuation in DNA Repair, Plays an Important Role in Estrogen-Induced Carcinogenesis....Pages 463-466
Pattern of Reproductive Aging in Female Rats Can Affect Mammary Tumor Incidence....Pages 467-470
Antiproliferative Activity of Luteolin, a Naturally-Occurring Edible Plant Flavone, Against Estrone-Induced Cell Proliferation in the Mammary Gland of Noble Rats....Pages 471-474
Sex Hormone-Induced Prostatic Carcinogenesis in Noble Rats Involves Genetic Damage and Cell Proliferation....Pages 475-479
Catechol Estrogen Analogs as Probes of Estrogen Carcinogenesis....Pages 480-483
 In-Vitro Metabolites of Coumestrol....Pages 484-488
Back Matter....Pages 489-500