Homocysteine Metabolism: From Basic Science to Clinical Medicine

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
The Regulation of Homocysteine Metabolism....Pages 3-9
Methionine Kinetics and Balance....Pages 11-22
On the Formation and Fate of Total Plasma Homocysteine....Pages 23-29
Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources....Pages 31-35
Genetics of Mammalian 5,10-Methylenetetrahydrofolate Reductase....Pages 37-42
Thermolabile Methylenetetrahydrofolate Reductase....Pages 43-49
The Long-Term Outcome in Homocystinuria....Pages 51-56
Characterization of the Human and Porcine Methionine Synthases and Their Redox Partners....Pages 57-60
Inherited Disorders of Folate and Cobalamin....Pages 61-68
Molecular Genetics of Cystathionine β-Synthase in Homocystinuria and Vascular Disease....Pages 69-76
Cystathionine β-Synthase Deficiency: Metabolic Aspects....Pages 77-82
Front Matter....Pages 83-83
Homocysteine and Other Metabolites in the Diagnosis and Follow-Up of Cobalamin and Folate Deficiencies....Pages 85-92
Vitamin Status and Hyperhomocysteinemia in a Healthy Population....Pages 93-98
Association Between Plasma Homocysteine, Vitamin Status, and Extracranial Carotid-Artery Stenosis in the Framingham Study Population....Pages 99-109
Treatment of Mild Hyperhomocysteinemia....Pages 111-116
Folate, Vitamin B 12 , and Neuropsychiatry Disorders....Pages 117-126
Vitamins, Homocysteine and Neural-Tube Defects....Pages 127-131
The Etiology of Neural Tube Defects....Pages 133-136
Plasma Homocysteine in Renal Failure, Diabetes Mellitus, and Alcoholism....Pages 137-143
Homocysteine and Drug Therapy....Pages 145-152
Front Matter....Pages 153-153
Is Methioninase Useful for the Prevention of Hyperhomocysteinemia-Associated Cardiovascular Disease?....Pages 155-156
Synthesis of Homocysteine Thiolactone in Normal and Malignant Cells....Pages 157-165
Folate Status: Modulation of Colorectal Carcinogenesis....Pages 167-176
The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine in Western Norway....Pages 177-182
Blood Homocysteine Levels in the National Health and Nutrition Examination Survey (Nhanes III) in the United States: Preliminary Findings by Age and Sex....Pages 183-187
Heritability of Plasma Homocysteine Concentration....Pages 189-191
Plasma Homocysteine and Coronary Artery Disease....Pages 193-197
Homocysteine and Cerebral and Peripheral Vascular Disease....Pages 199-204
Plasma Homocysteine and Its Relationship to Cardiovascular Risk Factors in a Japanese Population....Pages 205-210
Biological Chemistry of Thiols and the Role of Homocysteine in Vascular-Related Disease....Pages 211-222
Front Matter....Pages 223-223
Homocysteine and Vascular Disease: The European Concerted Action Project....Pages 225-238
Prospective Studies of Homocysteine and Cardiovascular Disease....Pages 239-244
A Meta-Analysis of Plasma Homocysteine as a Risk Factor for Arteriosclerotic Vascular Disease and the Potential Preventive Role of Folic Acid....Pages 245-249
Pathology of Homocystinuria....Pages 251-257
Lipoprotein(a), Homocysteine, and Atherogenesis....Pages 259-265
Endothelial- and Leukocyte-Mediated Mechanisms in Homocysteine-Associated Occlusive Vascular Disease....Pages 267-271
Back Matter....Pages 273-279