HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research

Front Matter ....Pages i-xxvii
Front Matter ....Pages 1-1
 What Is a B Cell Epitope  (Marc H V Van Regenmortel)....Pages 3-15
 Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Recognition Sites and Ill-Defined Structure-Function Relationships in Immunology  (Marc H V Van Regenmortel)....Pages 17-24
 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes  (Marc H V Van Regenmortel)....Pages 25-37
 Specificity, Polyspecificity and Heterospecificity of Antibody-Antigen Recognition  (Marc H V Van Regenmortel)....Pages 39-56
Front Matter ....Pages 57-57
 Reductionism and the Search for Structure: Function Relationships in Antibody Molecules  (Marc H V Van Regenmortel)....Pages 59-70
 Reductionism and Complexity in Molecular Biology: Scientists Now Have the Tools to Unravel Biological Complexity and Overcome the Limitations of Reductionism  (Marc H V Van Regenmortel)....Pages 71-78
 Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism  (Marc H V Van Regenmortel)....Pages 79-86
 The Rational Design of Biological Complexity: A Deceptive Metaphor  (Marc H V Van Regenmortel)....Pages 87-102
 Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking  (Marc H V Van Regenmortel)....Pages 103-126
 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking  (Marc H V Van Regenmortel)....Pages 127-129
 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases  (Marc H V Van Regenmortel)....Pages 131-140
Front Matter ....Pages 141-141
 Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogens  (Marc H V Van Regenmortel)....Pages 143-159
 Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Science  (Marc H V Van Regenmortel)....Pages 161-162
 Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developing an Effective HIV Vaccine  (Marc H V Van Regenmortel)....Pages 163-188
 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013  (Marc H V Van Regenmortel)....Pages 189-197
 Editorial: Paradigm Changes Are Required in HIV Vaccine Research  (Marc H V Van Regenmortel)....Pages 199-203
 An Outdated Notion of Antibody Specificity Is One of the Major Detrimental Assumptions of the Structure-Based Reverse Vaccinology Paradigm, Which Prevented It from Helping to Develop an Effective HIV-1 Vaccine  (Marc H V Van Regenmortel)....Pages 205-216
 More Surprises in the Development of an HIV Vaccine (General Commentary)  (Marc H V Van Regenmortel)....Pages 217-220
 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 Not Inform the Rational Design of an HIV-1 Vaccine?  (Marc H V Van Regenmortel)....Pages 221-228
 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop Held in Rome on 17 June 2016  (Marc H V Van Regenmortel)....Pages 229-248
 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because It Disregarded Accepted Immunological Theory  (Marc H V Van Regenmortel)....Pages 249-277
 Immune Systems Rather than Antigenic Epitopes Elicit and Produce Protective Antibodies Against HIV  (Marc H V Van Regenmortel)....Pages 279-281
 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design  (Marc H V Van Regenmortel)....Pages 283-298
 Viral Species, Viral Genomes and HIV Vaccine Design: Is the Rational Design of Biological Complexity a Utopia?  (Marc H V Van Regenmortel)....Pages 299-310
Back Matter ....Pages 311-364