Histone Deacetylase Inhibitors as Cancer Therapeutics

Content: 
Copyright
Page iv

Contributors
Pages ix-x

Preface
Pages xi-xii
Steven Grant

Chapter One - Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone Proteins
Pages 1-37
Brian Gabrielli, Mellissa Brown

Chapter Two - Mechanisms of Resistance to Histone Deacetylase Inhibitors
Pages 39-86
Ju-Hee Lee, Megan L. Choy, Paul A. Marks

Chapter Three - HDAC Inhibitors: Roles of DNA Damage and Repair
Pages 87-129
Carine Robert, Feyruz V. Rassool

Chapter Four - HDAC Inhibitor Modulation of Proteotoxicity as a Therapeutic Approach in Cancer
Pages 131-163
David J. McConkey, Matthew White, Wudan Yan

Chapter Five - Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Antitumor Activity
Pages 165-197
Geoffrey M. Matthews, Andrea Newbold, Ricky W. Johnstone

Chapter Six - Histone Deacetylase Inhibitors and Rational Combination Therapies
Pages 199-237
Steven Grant, Yun Dai

Chapter Seven - HDAC Inhibitors and Chaperone Function
Pages 239-262
Rekha Rao, Warren Fiskus, Siddhartha Ganguly, Suman Kambhampati, Kapil N. Bhalla

Index
Pages 263-270