Histamine and Histamine Receptors in Health and Disease

Front Matter....Pages i-viii
Analytical Methods for the Quantification of Histamine and Histamine Metabolites....Pages 3-19
Structural Analysis of the Histamine H1 Receptor....Pages 21-30
Molecular Modelling Approaches for the Analysis of Histamine Receptors and Their Interaction with Ligands....Pages 31-61
Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System....Pages 63-118
Histamine Release from Mast Cells and Basophils....Pages 121-139
Histamine H2 Receptor in Blood Cells: A Suitable Target for the Treatment of Acute Myeloid Leukemia....Pages 141-160
Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines....Pages 161-169
Histamine Clearance Through Polyspecific Transporters in the Brain....Pages 173-187
Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions....Pages 189-215
Histamine Food Poisoning....Pages 217-235
Regulation of the Cardiovascular System by Histamine....Pages 239-258
Changes in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptors in Neuropsychiatric Disorders....Pages 259-276
Role of the Histamine H3 Receptor in the Central Nervous System....Pages 277-299
Clinical Development of Histamine H4 Receptor Antagonists....Pages 301-320
Allergy, Histamine and Antihistamines....Pages 321-331
Histamine and Histamine Receptors in Allergic Dermatitis....Pages 333-345
Role of the Histamine H4-Receptor in Bronchial Asthma....Pages 347-359
Back Matter....Pages 361-363