Hereditary Diseases and Blood Transfusion: Proceedings of the Nineteenth International Symposium on Blood Transfusion, Groningen 1994, organized by the Red Cross Blood Bank Groningen-Drenthe

Front Matter....Pages I-XII
Front Matter....Pages 1-1
The Molecular Biology of Haemophilia....Pages 3-9
Molecular Biology of the Various Types of von Willebrand Disease....Pages 11-24
Molecular Basis of Thrombophilia....Pages 25-30
Inhibitory Sequences within the Clotting Factor VIII cDNA Block Transcriptional Elongation and Complicate Efforts Toward Gene Therapy for Haemophilia A....Pages 31-39
Back Matter....Pages 41-49
Front Matter....Pages 51-51
Globin Gene Regulation....Pages 53-61
Molecular Pathology of the Thalassaemia Syndromes....Pages 63-70
The Current Status of Bone Marrow Transplantation and Gene Therapy in the Management of the Haemoglobinopathies....Pages 71-80
The Molecular Biology of Blood Groups: Relevance to the Study of Erythroid Maturation and the Clinical Management of Haemolytic Disease of the Newborn....Pages 81-91
Genetic Abnormalities in Blood Group Serology....Pages 93-103
Back Matter....Pages 105-113
Front Matter....Pages 115-115
The Role of the Blood Bank in Human Gene Therapy Trials....Pages 117-129
Translocation in Cancer: Mechanism of Oncogenic Conversion and Implications for Therapy....Pages 131-143
Role of Topoisomerase II α and β Isozymes in Determining Drug Resistance in vitro and in vivo ....Pages 145-152
Impact of Cell Culture Technology on Transfusion Medicine....Pages 153-165
Gene Therapy for Primary Immune Deficiencies....Pages 167-171
Back Matter....Pages 173-179
Front Matter....Pages 181-181
Ethics and Genetic Manipulation....Pages 183-188
Is there a Role for Transfusion Medicine in the Genetic Correction of Genetic Disorders and other Diseases?....Pages 189-207
Vectors for Gene Therapy: Strategies for Making Gene Therapy Work....Pages 209-221
From Blood Stain to Pathogenesis Study of Human Hereditary Diseases....Pages 223-232
The Potential Impact of Gene Therapy in Blood Transfusion....Pages 233-242
Back Matter....Pages 243-250
Back Matter....Pages 251-259