Hereditary Colorectal Cancer: Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan

Front Matter....Pages I-XXIV
Front Matter....Pages 1-1
The Concept of Hereditary Colorectal Cancer and the Implications of Its Study....Pages 3-16
Historical and Natural Cancer History Facets of the Lynch Syndromes....Pages 17-25
Eldon Gardner Memorial Lecture: Genetic Mapping and Allelic Heterogeneity of the Familial Polyposis Gene....Pages 27-36
Hereditary Colorectal Cancer: A Commentary....Pages 37-42
Front Matter....Pages 43-43
Summary of Chapter 2: Identification, Surveillance and Management of Polyposis Syndrome....Pages 45-49
Familial Adenomatous Polyposis Study: The Report of the Leeds Castle Polyposis Meeting....Pages 51-54
Surveillance of Danish Families with Adenomatous Polyposis: Results of the Danish Polyposis Register....Pages 55-56
Value of Registration in the Identification and Surveillance of Familial Adenomatous Polyposis in the Netherlands....Pages 57-62
Current Status of the Registration of Familial Adenomatous Polyposis at the Polyposis Center in Japan....Pages 63-69
Management of Familial Polyposis in Poland....Pages 71-74
The Probability of Developing Familial Adenomatous Polyposis: Combining the Diminishing Risks with Age with Negative Screening at Advancing Age and Linked Gene Markers....Pages 75-80
Follow-up Study of Associated Tumors in Cases of Familial Adenomatous Polyposis....Pages 81-89
Retinal Pigmentations in Familial Adenomatous Polyposis, and Linkage Study on Gene Probes on Chromosome 5q....Pages 91-96
Congenital Hypertrophy of the Retinal Pigment Epithelium: A Clinical Marker for Familial Adenomatous Polyposis....Pages 97-99
Front Matter....Pages 101-101
Summary of Chapter 3: Identification, Surveillance and Management of Hereditary Non-polyposis Colorectal Cancer....Pages 103-105
Hereditary Nonpolyposis Colorectal Cancer and Tumorigenesis in the Human Body....Pages 107-113
Colonoscopy Findings in a Series of Patients with Hereditary Colorectal Cancer....Pages 115-117
Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer....Pages 119-126
Endometrial Cancer as Heterogenic Picture of HNPCC: Population-Based Studies in Sweden....Pages 127-130
A Monoclonal Antibody C12 Against Endometrial Carcinoma, Recognize Polyfucosyl Lactosamine-Bearing Glycoprotein....Pages 131-134
Front Matter....Pages 101-101
A Pedigree of Cancer Family Syndrome with an Aggregation of Transitional Cell Cancer of the Urinary Tract....Pages 135-141
Screening for Hereditary Non-polyposis Colorectal Cancer in the Netherlands....Pages 143-149
The Risks of Colorectal Cancer and the Frequency of Recognised Family Cancer Syndromes in 550 Sequential Referrals for Family Risk of Colorectal Cancer....Pages 151-155
The Incidence of Colorectal Cancer Among First Degree Relatives of Patients with Colorectal Cancer....Pages 157-158
Genetics of Adenomas....Pages 159-162
Surveillance of High Risk Individuals with Family History using Guaiac Test (Hemoccult II)....Pages 163-168
Studies on Relatives of Sporadic Colorectal Cancer Patients....Pages 169-173
Managing Surveillance for Colorectal Cancer: The Importance of Microcomputers....Pages 175-183
Hereditary Non-polyposis Colorectal Cancer: The University of Texas MD Anderson Cancer Center Experience....Pages 185-191
Medical/Legal Concerns in the Management of Patients from Lynch Syndromes Kindreds....Pages 193-201
The Research Nurse/Family Contact Person and Hereditary Colon Cancer....Pages 203-209
Surgical Strategies for Management of the Lynch Syndromes....Pages 211-217
An Attempt for Identification of Hereditary Nonpolyposis Colorectal Cancer in Japan....Pages 219-224
Front Matter....Pages 225-225
Summary of Chapter 4: Chemoprevention of Colorectal Cancer....Pages 227-230
Primary and Secondary Chemoprevention of Colorectal Cancer....Pages 231-238
Chemoprevention of Large Bowel Cancer in Animal Models and Its Possibility in Humans....Pages 239-248
Inhibitory Effect of Eicosapentaenoic Acid on Colon Carcinogenesis....Pages 249-256
Life Styles and Cancer of the Sigmoid Colon with Special Reference to the Role of Alcohol Consumption....Pages 257-264
Calcium Regulation of Colon Epithelial Cytokinetics in High Risk Subjects for Colon Cancer: Application of New Proliferation Markers....Pages 265-270
Ornithine Decarboxylase (ODC) and S-Adenosylmethionine Decarboxylase (AdoMetDC) as Markers of Human Colonic Neoplasia....Pages 271-274
Front Matter....Pages 225-225
Dietary Fiber or Piroxicam as Potential Cancer Prevention Agents: Effects on Rectal Epithelial Cell Proliferation in Humans at Increased Risk of Colon Cancer....Pages 275-282
Long-Term Effects of Dietary Calcium on Risk Markers for Colon Cancer in Familial Polyposis Patients....Pages 283-291
Chemoprevention Using Wheat Fiber and Vitamins C and E in Patients with Familial Adenomatous Polyposis....Pages 293-300
Ornithine Decarboxylase (ODC) and S-Adenosylmethionine Decarboxylase (AdoMetDC) as Markers in Human Colonic Neoplasia....Pages 301-305
Chemoprevention Trials in Patients with Familial Adenomatous Polyposis (FAP) at Roswell Park Cancer Institute....Pages 307-312
Front Matter....Pages 313-313
Summary of Chapter 5: Clinicopathological Aspects of Inherited Colorectal Cancer Syndromes....Pages 315-320
Pathology of Gastroenteric Lesions in Familial Adenomatosis Coli....Pages 321-330
The Peutz-Jeghers Syndrome and Malignant Tumor....Pages 331-336
Histogenesis of Gastrointestinal Carcinoma in Peutz-Jeghers Polyp....Pages 337-342
Pathology of Polyposis Syndromes with Special Reference to Juvenile Polyposis....Pages 343-350
Clinicopathologic Features of Flat Adenoma of the Large Bowel....Pages 351-356
Histologic Features of Hereditary Nonpolyposis Colorectal Carcinoma....Pages 357-362
Crypt Atrophy of Colorectal Mucosa in Lynch Syndromes I and II: Its Characteristics and Meaning, Preliminary Observations....Pages 363-368
Cellular Immune Response in Lynch Syndrome II on Gastrointestinal Biopsy....Pages 369-375
Glycoconjugate Expression in Familial Colorectal Cancer: Polyposis Syndromes and Hereditary Nonpolyposis Syndromes....Pages 377-385
Carbohydrate Associated Antigens in Neoplastic and Preneoplastic Colon....Pages 387-392
Interphasic Nucleolar Organizer Regions in Colorectal Dysplastic and Neoplastic Lesions....Pages 393-398
Cultured Skin Fibroblasts from Hereditary Colorectal Cancer Patients: Susceptibility Mechanisms, Genetics, and Biomarkers....Pages 399-410
Front Matter....Pages 411-411
Summary of Chapter 6: Cytomolecular Aspects of Polyposis....Pages 413-415
Two Cases of Familial Adenomatous Polyposis Associated with Mental Retardation....Pages 417-422
Front Matter....Pages 411-411
Pedigree Analysis of Susceptibility to Colonic Adenomas....Pages 423-430
Genetic Linkage Study of Juvenile Polyposis: Preliminary Analysis....Pages 431-432
Linkage Studies on Familial Adenomatous Polyposis in the Netherlands....Pages 433-440
Genetic Counseling for Familial Adenomatous Polyposis with Chromosome 5q Linkage Information....Pages 441-444
Allele Loss and Kras Mutation Involved in the Development of Colorectal Tumors in Patients with Familial Adenomatous Polyposis....Pages 445-452
Status of the APC Gene in Familial and Sporadic Colorectal Tumours as Determined by Closely Flanking Markers....Pages 453-456
Strategies for Cloning the Gene for Adenomatous Polyposis Coli....Pages 457-460
Genetic and Molecular Analysis of Familial Polyposis Coli....Pages 461-467
Searching the Gene Responsible to Familial Polyposis Coli (FAP)....Pages 469-472
Front Matter....Pages 473-473
Summary of Chapter 7: Cytomolecular Aspects of Colorectal Cancer....Pages 475-476
Genetic Alterations in Colorectal Tumors....Pages 477-482
 Ras and c- myc Oncoprotein Expression in Human Colorectal Tumors....Pages 483-487
Molecular Analysis of the Retinoblastoma (Rb) Gene in Human Colorectal Carcinomas....Pages 489-496
Cellular and Molecular Events Involved in Tumour Progression in Colorectal Carcinogenesis: A Study of the Adenoma Carcinoma Sequence In Vitro....Pages 497-507
Genetic Alterations in Colorectal Cancers in Correlation to Clinical Parameters....Pages 509-516
Clinical and Pathological Associations with Molecular Genetic Alterations in Colorectal Carcinoma....Pages 517-518
A Subset of Genetic Alterations Distinguish Distal from Proximal Colorectal Cancer....Pages 519-527
Chromosome 5 Deletions as a Means of Defining the APC Region....Pages 529-532
Cytogenetic Studies on Colon Carcinomas and Adenomas from Patients with Familial Polyposis Coli....Pages 533-540
The DiFi Rectal Carcinoma Cell Line from a Familial Adenomatous Polyposis Patient: An In Vitro Model System to Study Genetic Changes in Colorectal Cancer....Pages 541-548
Front Matter....Pages 473-473
Dietary Fat Diglycerides Activate by Tyrosine Phosphorylation a pp63 Membrane Protein Only in Colon Tumors and not in Normal Colonocytes, Leading to Selective Biological Effects....Pages 549-553
Overview and Epilogue....Pages 555-572
Back Matter....Pages 573-575