Hereditary and Familial Colorectal Cancer

Table of Contents
Foreword
Contributors
Introduction
Introductory Chapters
	1. Historical Aspects of Familial Polyposis and Lynch Syndrome • Éanna J. Ryan, Odhrán K. Ryan, Des C. Winter
	2. Clinical and Molecular Overview of Colorectal Cancer Predisposition Syndromes • Tarik Sammour
Lynch Syndrome and the Mismatch Repair System
	3. Lynch Syndrome • James Hill, Mark J. Arends, Ian M. Frayling
	4. Extra Colonic Cancer Risk in Lynch Syndrome • Sanne W. ten Broeke, Anne-Sophie van der Werf- ’t Lam, Maartje Nielsen
	5. Surgical Management of Lynch Syndrome • Sue Clark
	6. Gynaecological Malignancy in Lynch Syndrome • Helena C. Bartels, Ruaidhri McVey, Donal J. Brennan
	7. Urological Malignancy in Lynch Syndrome • Usman M. Haroon, Barry B. McGuire
	8. Constitutional Mismatch Repair Deficiency • Noelle M. Cullinan, Terri P. McVeigh
Adenomatous Polyposis Syndromes
	9. Familial Adenomatous Polyposis • Michael E. Kelly, Ben Creavin, Odhrán K. Ryan, Antonino Spinelli
	10. Surgical Management of Polyposis Syndromes • Alexandra Zaborowski, Ann M. Hanly
	11. Attenuated FAP and Genotype-Phenotype Correlations with APC Mutations • Selvi Thirumurthi, Julie B. Moskowitz, Y. Nancy You
	12. MUTYH-Associated Polyposis • Terri P. McVeigh
	13. POLE and POLD1 Mutations, and Polymerase Proofreading Associated Polyposis • Michael P. Flood, Alexander G. Heriot
	14. NTHL1 Tumour Syndrome • Laura Valle, Gabriel Capellá
Hamartomatous Polyposis
	15. Peutz-Jehger’s Syndrome • Neeraj Lal, Andrew D. Beggs
	16. Juvenile Polyposis Syndrome • Mohamad M. Adada, Brooke R. Druliner, Rondell P. Graham, Lisa A. Boardman
	17. PTEN Hamartoma Tumour Syndrome • Andrew Latchford
Mixed Polyposis
	18. Mixed Polyposis Syndrome: Features and Management • Mohammad Ali Abbass, Brandie Leach, Matthew F. Kalady
Serrated Polyposis
	19. Serrated Polyposis Syndrome • Daniel D. Buchanan, Emma Anthony, Jihoon E. Joo, Susan Parry, Christophe Rosty
The Specialist Clinic & Genetic Testing
	20. Managing the Multiple Adenoma Patient and Multidisciplinary Decision-Making • Áine Stakelum, Éanna J. Ryan, Rory Kennelly
	21. Universal Tumour Screening for Lynch Syndrome • Vanessa Palter, Nancy N. Baxter
	22. Hereditary Colorectal Cancer Predisposition Syndromes for the Pathologist • Susan Aherne, Maura B. Cotter, Kieran Sheahan
	23. Hereditary Colorectal Cancers for the Oncologist • Adesola Ogunsakin, Sheron Perera, Grainne M. O’Kane
	24. Obtaining and Using Genetic Information, Classification of Genetic Variants, and Genetic Counseling • Emma R. Woodward, D. Gareth Evans
	25. Estimation of Risk, and Modifiers of Penetration in Familial and Hereditary Colorectal Cancer • Paul Armstrong, Éanna J. Ryan, Des C. Winter, Gareth Horgan
	26. High-Risk Population Surveillance in Familial and Inherited Colorectal Cancer • Kevin Monahan, Benjamin Norton
Future Developments
	27. The Role of Next Generation Sequencing: Lynch-Like Syndrome, Familial Colorectal Cancer Type X, Unexplained Polyposis Syndrome and Emerging Colorectal Cancer Susceptibility Genes • Xiaoyu Yin, Lachlan O’Connell, Daniel D. Buchanan, Finlay Macrae
	28. Chemoprevention in Colorectal Cancer Predisposition SyndromesElena M. Stoffel
	29. The Immune Landscape of Colorectal Cancer with Microsatellite Instability • Éanna J. Ryan, Odhrán K. Ryan, Noel E. Donlon, Helen M. Mohan, Séan T. Martin
	30. Application of Multi-Omics Strategies in Hereditary Colorectal Cancer • Christina Fleming, Eric Rullier, Quentin Denost