Hepatic Transport of Organic Substances

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Glutamate-sodium Cotransport in the Kidney: An Example for the Plasticity of Transport Systems....Pages 3-11
Energetic Coupling in Secondary Active Transport....Pages 12-20
The Passage of Molecules into Bile: Paracellular and Transcytotic Pathways....Pages 21-32
Increase in Paracellular Permeability as a Pathophysiological Principle of Drug-Induced Intrahepatic Cholestasis in Rats....Pages 33-34
The Hepatocyte’s Plasma Membrane Domains. Interrelations with the Endocytic Compartment....Pages 35-44
Hepatic Spaces and Transport in the Perfused Liver....Pages 45-57
New Methodologic Approaches for the Study of Transport in the Liver....Pages 58-73
Transport Processes in Mammalian Gallbladder and Bile Duct....Pages 74-84
Transcellular Butyrate Transport in Gallbladder Epithelium....Pages 85-86
Accessibility of Primary Bile in Liver Cell Culture....Pages 87-88
Polarity of the Hepatocyte Surface Membrane: Influence of Lipids on Protein Function....Pages 89-101
ATP in and Around the Bile Canaliculus....Pages 102-117
Front Matter....Pages 119-119
Glutathione Conjugate Transport in Hepatic Elimination of Electrophiles....Pages 121-130
Hepatobiliary Cysteinyl Leukotriene Elimination....Pages 131-140
Biliary Excretion of Thiols and Their Role in Elimination of Methylmercury....Pages 141-153
Glutamine and Glutamate Transport in Perfused Liver....Pages 157-166
Regulation of Hepatic Amino Acid Transport and Partial Purification of the System A Carrier....Pages 167-176
Hormonal Control of Amino Acid Transport Systems in Cultured Periportal and Perivenous Hepatocytes....Pages 177-187
Differential Inactivation of System A in Normal and Transformed Liver Cells....Pages 188-189
Mechanism of Renal Transport of L-Alanine in Luminal Membrane Vesicles....Pages 190-191
Front Matter....Pages 119-119
Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes....Pages 195-210
Mechanism of Hepatic Fatty Acid Uptake....Pages 211-220
Studies on the Mechanism of Organic Anion Transport by the Liver....Pages 221-232
Mechanisms of Sinusoidal Bile Acid Transport....Pages 233-239
Binding and Uptake of Taurocholate in Subcellular Organelles from Rat Liver....Pages 240-256
The Ontogeny of Hepatic Bile Acid Transport....Pages 257-266
Identification and Function of Bile Salt Binding Polypeptides of Hepatocyte Membrane....Pages 267-278
Characterization of the Bile Acid Transport System in Normal and Transformed Hepatocytes Using Monoclonal Antibodies....Pages 279-285
Transport of Bile Salts Across the Canalicular Plasma Membrane....Pages 286-294
Biliary Taurocholate Excretion During the Metabolism of 2-Methyl-1, 4-Naphthoquinone (Menadione) in Perfused Rat Liver....Pages 295-296
Comparison of Bile Salt-Binding Proteins in Basolateral Membranes from Small Intestine, Kidney, and Liver....Pages 297-298
Effects of Hydrostatic Pressure and Liver Cell Membrane Potential on Hepatic Bile Acid Transport....Pages 299-300
Characterization and Purification of Bile Acid Transport Proteins....Pages 301-302
Transport of Taurocholate in Isolated Cells from Ileum, Liver and Kidney....Pages 303-304
Properties of the Taurocholate Uptake System in Basolateral Rat Liver Plasma Membrane Vesicles: Effects of Albumin and Substrate Specificity....Pages 305-306
Uptake of Foreign Cyclopeptides by Liver Cells....Pages 309-316
Identification of Carrier Proteins in Hepatocytes by (Photo) Affinity Labels Derived from Foreign Cyclopeptides....Pages 317-326
Uptake of Xenobiotics by the Bile Acid Transport System in the Liver: Relationship Between the Organic Anion Transport Systems in the Kidney and the Liver....Pages 327-343
Mechanisms for Hepato-Biliary Transport of Cationic Drugs Studied with the Intact Organ and on the Membrane Level....Pages 344-367
The Role of Liver and Extrahepatic Organs in the Metabolism of N-Nitrosodibutylamine (NDBA): Comparison of in Vitro with in Vivo Data....Pages 368-369
Front Matter....Pages 119-119
The Role of Biliary Excretion and Intestinal Metabolism for Toxokinetics and Toxicity of T-2 Toxin, a Major Trichothecene Mycotoxin....Pages 370-371
Binding Proteins for Dipeptides, β-Lactam Antibiotics, and p-Aminohippurate (PAH) in Plasma Membranes from Small Intestine and Kidney....Pages 372-373
Transport Properties of Steroid Glucuronides....Pages 377-387
Intestinal Transport of Glucuronides and Sulpho-Conjugates....Pages 388-389
Transport of Thyroid Hormone (TH) into Hepatocytes....Pages 390-402
Metabolism of Thyroid Hormone in Liver....Pages 403-404
Concluding Remarks....Pages 405-410
Back Matter....Pages 411-435