Hemostatic Mechanisms and Metastasis

Front Matter....Pages i-xxi
Is there Clinical Relevance for Therapies which Disrupt the Metastatic Cascade?....Pages 1-14
Overview of the Metastatic Cascade....Pages 15-38
Overview on Blood Coagulation Proteins....Pages 39-55
The Microinjury Hypothesis and Metastasis....Pages 56-61
Hemostatic Abnormalities in Tumor-Bearing Animals....Pages 62-71
Evidence for a Tumor Proteinase in Blood Coagulation....Pages 72-83
Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells....Pages 84-95
Fibrin Formation: Implications for Tumor Growth and Metastasis....Pages 96-114
Perspectives on the Role of Platelets in Hemostasis and Thrombosis....Pages 115-126
Mechanisms of Platelet Aggregation by Murine Tumor Cell Sheddings....Pages 127-138
Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacologic Strategy toward Prevention of Metastases....Pages 139-169
Tumor Cysteine Proteinases, Platelet Aggregation and Metastasis....Pages 170-191
Arachidonate Metabolism in Platelets and Blood Vessels....Pages 192-206
Prostacyclin/Thromboxanes and Tumor Cell Metastasis....Pages 207-231
Evidence for Altered Arachidonic Acid Metabolism in Tumor Metastasis....Pages 232-243
Calcium Channel Blockers: Inhibitors of Tumor Cell-Platelet-Endothelial Cell Interactions....Pages 244-258
Evidence for the Antimetastatic Effects of Coumarin Derivatives....Pages 259-265
Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors....Pages 266-281
Role of the Vascular Endothelium in Hemostasis....Pages 282-294
The Cellular Interactions of Metastatic Tumor Cells with Special Reference to Endothelial Cells and their Basal Lamina-Like Matrix....Pages 295-318
Interaction of Tumor Cells with the Basement Membrane of Endothelium....Pages 319-341
Hemostatic Alterations in Cancer Patients....Pages 342-354
Historical Overview of Clinical Experience with Anticoagulant Therapy....Pages 355-367
Rationale for Anticoagulant Treatment of Cancer....Pages 368-374
The Design and Execution of Anticoagulant Therapy Trials in Cancer....Pages 375-386
Experimental and Clinical Experience with Pyrimido-Pyrimidine Derivatives in the Inhibition of Malignant Metastasis Formation....Pages 393-408
Current Clinical Trials with Anticoagulant Therapy in the Management of Cancer Patients....Pages 409-425
Back Matter....Pages 426-432