Hemoglobin and Red Cell Structure and Function: Proceedings of the Second International Conference on Red Cell Metabolism and Function held at the University of Michigan Ann Arbor, April 27–29, 1972

Front Matter....Pages i-xxxii
Front Matter....Pages 1-1
Structure of Haemoglobin M Milwaukee, A Mutant Form Exhibiting Interaction Between Ferrous and Ferric Subunits....Pages 3-18
The Interaction Between Hemoglobin and Its “Oxygen-Linked” Ligands....Pages 19-40
The Interaction of Sickle Hemoglobin with DPG, CO 2 and with Other Hemoglobins: Formation of Asymmetrical Hybrids....Pages 41-53
Enhancement of the Acid and Alkaline Bohr Effects of Hemoglobin by Organic Phosphates....Pages 55-63
Functional Non-Equivalence of α and β Hemes in Human Hemoglobins....Pages 65-76
Front Matter....Pages 77-77
Hemoglobin Casper G8 β106 Leu→ Pro: Further Evidence that Hemoglobin Mutations are Not Random....Pages 79-98
Potential Effects of Hemoglobin Concentration on Red Cell Metabolism Together with Observations on Red Cell Metabolic Differences Between Men and Women....Pages 99-119
Catalase Activity and Red Cell Metabolism....Pages 121-131
Red Cell Hexosemonophosphate Shunt Deficiency in Uremia....Pages 133-143
Effect of Inorganic Phosphate on Red Cell Metabolism: In Vitro and In Vivo Studies....Pages 145-154
Studies of the Metabolic Basis of the ATP-DPG Differences in Genetically Selected High and Low ATP-DPG Rat Strains....Pages 155-164
Front Matter....Pages 165-165
Introductory Remarks at the Beginning of Session III....Pages 167-168
Functional Aspects of the Three-Dimensional Structure of the Active Site of Carbonic Anhydrase....Pages 169-187
The Effect of Temperature on the Catalytic Activity of Bovine Carbonic Anhydrase....Pages 189-199
Carbonic Anhydrase, Red Cell Membranes, and CO 2 Transport....Pages 201-208
Effect of Chlorthalidone Binding on the Electrophoretic Properties of Human Red Cell Carbonic Anhydrase Isozymes....Pages 209-213
The Role of Carbonic Anhydrase in the Control of Intracellular pH....Pages 215-224
The Contribution of Carbamate in Human Adult and Foetal Blood to the CO 2 Exchange During the Respiratory Cycle....Pages 225-236
Front Matter....Pages 237-237
Introductory Remarks at the Beginning of Session IV....Pages 239-241
Thermal (Or Endothermic) Aggregation of Sickle Cell Hemoglobin (Hb S) During Sickling....Pages 243-251
Front Matter....Pages 237-237
Chemical and Biological Aspects of the Inhibition of Red Blood Cell Sickling by Cyanate....Pages 253-260
Preliminary Clinical Trials with Cyanate....Pages 261-278
Carbamyl Phosphate Modification of Hemoglobin S Structure Resulting in Altered Sickling....Pages 279-296
Oxygen Affinity Independent Action of Cyanate and 2,3 DPG on Sickling....Pages 297-302
Evaluation of Oral Urea in the Management of Sickle Cell Anemia....Pages 303-323
The Sickling Phenomenon of Deer Erythrocytes....Pages 325-336
Further Studies on the Antenatal Detection of Sickle Cell Anemia and other Hemoglobinopathies....Pages 337-346
Front Matter....Pages 347-347
Adjustments of the Oxygen Transport System During Residence at High Altitude....Pages 349-360
Red Cell Metabolism and Oxygen Affinity of Healthy Individuals During Exposure to High Altitude....Pages 361-375
Enzymatic Mechanisms of Red Cell Adaptation to Anemia....Pages 377-396
Red Cell Metabolic Changes in Acute and Chronic Exposure to High Altitude....Pages 397-413
Effects of Cyanate in Rabbits....Pages 415-430
Front Matter....Pages 431-431
Studies on the Ability of Stored Blood to Transport Oxygen In Vivo....Pages 433-447
The Two Bohr Effects: Physiological Consequences of Ligand Interaction with Hemoglobin....Pages 449-455
Rejuvenation and Freezing of Outdated Human Red Cells....Pages 457-477
Effects of Adenine on Stored Human Red Cells....Pages 479-494
Hemoglobin Function During Blood Storage XV: Effects of Metabolic Additives Inosine and Methylene Blue on p50 and 2,3-DPG....Pages 495-509
The Effect of Massive Transfusion of Stored Blood on Oxygen Transport — A Preliminary Report....Pages 511-516
Back Matter....Pages 517-526