Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Cover
Half Title
Title Page
Copyright Page
CONTENTS
Foreword
Preface
Acknowledgments
About the Editors
List of Contributors
SECTION I: BIOLOGY OF IMMUNE CELLS
	1. B Cells in Aging, Age-Associated Diseases and Stem Cell Transplantation
	2. T Cell Biology: Changes with Disease, Aging, and Hematopoietic Stem Cell Transplantation
	3. Plasma Cells in Autoimmunity
	4. Car T Cells for Autoimmunity
	5. Regulatory T Cells for the Treatment of Autoimmune Diseases
	6. Mesenchymal Stromal Cell-Derived Extracellular Vesicles
SECTION II: BIOLOGY OF STEM CELLS
	7. Induced Pluripotent Stem Cells: The Story of Genetic Reprogramming
	8. Mesenchymal Stromal Cell Biology and Clinical Application
	9. Neural Stem Cell Biology
	10. Hematopoietic Stem Cells: Hierarchical versus Continuum
	11. Biology of Umbilical Cord Blood Cells
SECTION III: REGULATORY REQUIREMENTS
	12. Quality, Accreditation, and Regulation in Hematopoietic Stem Cell Transplantation
	13. European Perspective on Cellular Therapy: Good Tissue Practice (GTP) versus Good Manufacturing Practice (GMP)
	14. GMP Facility Requirements in the United States
SECTION IV: MESENCHYMAL STEM CELLS FOR IMMUNE DISEASES
	15. Mesenchymal Stromal Cell Therapy for Acute Graft versus Host Disease—From Bench to Clinical Approval
	16. Adipose-Derived Stem Cells for Systemic Sclerosis Digital Ulcers
	17. Musculoskeletal Stromal/Progenitor Cell-Based Cell Therapy for Rheumatoid Arthritis (RA): MSC for Cell Therapy in RA
	18. Mesenchymal Stromal Cells for Systemic Sclerosis
	19. Mesenchymal Stem Cells (MSC) for Systemic Lupus Erythematosus (SLE)
	20. Mesenchymal Stem/Stromal Cells for Multiple Sclerosis and Other Neurological Diseases
	21. Mesenchymal Stromal Cells for Perianal Fistulizing Crohn’s Disease
	22. Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder
SECTION V: GENERAL CONCEPTS—HSCT FOR AUTOIMMUNE DISEASES
	23. Animal Models of Bone Marrow Transplantation for Autoimmune Diseases
	24. Autologous HSCT Conditioning Regimens for Autoimmune Diseases
	25. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Autoimmune Disease
	26. Microbiota and Immune Response
	27. Infectious Complications in Patients Undergoing HSCT for Autoimmune Diseases
	28. Early Toxicity and Supportive Care of HSCT for Autoimmune Diseases
	29. Late Toxicity and Supportive Care of Patients Undergoing Hematopoietic Cell Transplantation for Autoimmune Diseases
	30. Transfusion Medicine
	31. International Registries Sites/Indications/Activity for HSCT in Autoimmune Diseases: The European Society for Blood and Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR)
	32. Hematopoietic Stem Cell Mobilization, Collection, Apheresis, and Harvest Procedures
SECTION VI: ALLOGENEIC HSCT FOR AUTOIMMUNE DISEASE
	33. Hematopoietic Stem Cell Donor Registries: Search Strategies and HLA Methodologies
	34. Allogeneic HSCT and Graft versus Host Disease (GvHD): General Principles with Reference to Autoimmune Diseases
	35. Hematopoietic Cell Transplantation in Monogenic Autoimmune Diseases
	36. Advances in the Pathogenesis and Treatment of Immune-Mediated Aplastic Anemia
SECTION VII: HSCT FOR AUTOIMMUNE DISEASE
	37. Magnetic Resonance Imaging in Multiple Sclerosis
	38. Multiple Sclerosis
	39. Disease-Modifying Therapies and Supportive Care of Multiple Sclerosis
	40. Autologous Hematopoietic Stem Cell Transplantation for Secondary Progressive Multiple Sclerosis
	41. Autologous Hematopoietic Stem Cell Transplantation for Relapsing-Remitting Multiple Sclerosis
	42. Immune Mechanisms of Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis
	43. Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Basics and Interpretation of Electrodiagnostic Testing
	44. Diagnosis and Differentiation of CIDP from Other Peripheral Polyneuropathies
	45. Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy
	46. Neuromyelitis Optica: Autologous and Allogeneic HSCT for AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorders
	47. Systemic Sclerosis
	48. The Systemic Sclerosis Heart
	49. Scleroderma Renal Crisis with Special Considerations for Autologous Hematopoietic Stem Cell Transplant
	50. Systemic Sclerosis and the Lung
	51. Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis
	52. Crohn’s Disease: Incidence, Diagnosis, Standard Treatment, Prognosis, Outcome Measures
	53. Hematopoietic Stem Cell Transplantation an Alternative to Treat Crohn’s Disease
	54. Type 1 Diabetes Mellitus: Hematopoietic Stem Cell Transplantation for Type 1 Diabetes Mellitus
	55. Systemic Lupus Erythematosus: Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus (SLE)
SECTION VIII: HSCT FOR AUTOIMMUNE DISEASE—DEVELOPING INDICATIONS
	56. Refractory Celiac Disease: Hematopoietic Stem Cell Transplantation for Refractory Celiac Disease Type II
	57. Hematopoietic Stem Cell Transplantation for Juvenile Idiopathic Arthritis
	58. Hematopoietic Stem Cell Transplantation for Rheumatoid Arthritis
	59. Hematopoietic Stem Cell Transplantation for Behçet’s Syndrome
	60. Hematopoietic Stem Cell Transplantation and Myasthenia Gravis
	61. Autologous Hematopoietic Stem Cell Transplantation in Stiff Person Spectrum Disorder
	62. Hematopoietic Stem Cell Transplant-Based Treatment for Psychiatric Disorders
	63. Hematopoietic Stem Cell Transplantation for Psoriasis and Pemphigus Vulgaris
SECTION IX: ETHICS AND ECONOMICS
	64. Health Economics of Autoimmune Diseases Using Multiple Sclerosis as a Model
	65. Is Health Care a Human Right?
	66. Ethics of Stem Cells and Stem Cell Transplantation for Autoimmune Diseases
Appendices
Index