Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and Clinical Implications

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Cardiac Ion Channels and Heart Rate and Rhythm....Pages 3-31
Ionic Basis of the Pacemaker Activity of SA Node Revealed by the Lead Potential Analysis....Pages 33-58
The “Funny” Pacemaker Current....Pages 59-81
Novel Perspectives on Cardiac Pacemaker Regulation: Role of the Coupled Function of Sarcolemmal and Intracellular Proteins....Pages 83-99
Pacemaker Activity of the SA Node: Insights from Dynamic-Clamp Experiments....Pages 101-117
Heart Rate Variability: Molecular Mechanisms and Clinical Implications....Pages 119-132
Mechano-Electric Feedback in the Heart: Effects on Heart Rate and Rhythm....Pages 133-151
Front Matter....Pages 153-153
A Historical Perspective on the Development of Models of Rhythm in the Heart....Pages 155-173
Simulation of Cardiac Action Potentials....Pages 175-194
Front Matter....Pages 195-195
Development of Pacemaker Activity in Embryonic and Embryonic Stem Cell-Derived Cardiomyocytes....Pages 197-209
Molecular Basis of the Electrical Activity of the Atrioventricular Junction and Purkinje Fibres....Pages 211-230
Molecular Basis and Genetic Aspects of the Development of the Cardiac Chambers and Conduction System: Relevance to Heart Rhythm....Pages 231-253
Role of the T-Tubules in the Response of Cardiac Ventricular Myocytes to Inotropic Interventions....Pages 255-266
Front Matter....Pages 267-267
An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue....Pages 269-282
Post-infarction Remodeling and Arrhythmogenesis: Molecular, Ionic, and Electrophysiological Substrates....Pages 283-304
The Role of Intracellular Ca 2+ in Arrhythmias in the Postmyocardial Infarction Heart....Pages 305-322
Molecular and Biochemical Characteristics of the Intracellular Ca 2+ Handling Proteins in the Heart....Pages 323-335
Pharmacological Modulation and Clinical Implications of Sarcolemmal Ca 2+ -Handling Proteins in Heart Function....Pages 337-349
Calmodulin Kinase II Regulation of Heart Rhythm and Disease....Pages 351-364
MicroRNA and Pluripotent Stem Cell-Based Heart Therapies: The Electrophysiological Perspective....Pages 365-383
Front Matter....Pages 385-385
Intracellular Calcium Handling and Inherited Arrhythmogenic Diseases....Pages 387-408
Molecular Mechanisms of Voltage-Gated Na + Channel Dysfunction in LQT3 Syndrome....Pages 409-429
The Short QT Syndrome....Pages 431-449
Adrenergic Regulation and Heritable Arrhythmias: Key Roles of the Slowly Activating Heart I Ks Potassium Channel....Pages 451-460
Defects in Ankyrin-Based Protein Targeting Pathways in Human Arrhythmia....Pages 461-472
Genetically Modified Mice: Useful Models to Study Cause and Effect of Cardiac Arrhythmias?....Pages 473-484
Genetics of Atrial Fibrillation....Pages 485-499
Front Matter....Pages 501-501
The Role of Gap Junctions in Impulse Propagation in the Heart: New Aspects of Arrhythmogenesis and New Antiarrhythmic Agents Targeting Gap Junctions....Pages 503-524
Possible Mechanisms of the Acute Ischemia-Induced Ventricular Arrhythmias: The Involvement of Gap Junctions....Pages 525-542
Role of NCX1 and NHE1 in Ventricular Arrhythmia....Pages 543-561
TRP Channels in Cardiac Arrhythmia: Their Role During Purinergic Activation Induced by Ischemia....Pages 563-579
Cardiac Aquaporins: Significance in Health and Disease....Pages 581-595
Front Matter....Pages 597-597
Ion Channels as New Drug Targets in Atrial Fibrillation....Pages 599-610
hERG1 Channel Blockers and Cardiac Arrhythmia....Pages 611-625
Preclinical Drug Safety and Cardiac Ion Channel Screening....Pages 627-638
QT Prolongation Is a Poor Predictor of Proarrhythmia Liability: Beyond QT Prolongation!....Pages 639-654
K Channel Openers as New Anti-arrhythmic Agents....Pages 655-668
Back Matter....Pages 669-678