Head and Neck Pathology

Cover
Head and Neck Pathology
Other books in this series
Copyright Page
■ Contributors
■ Foreword
■ Preface
■ Acknowledgments
1 Non-Neoplastic Lesions of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx
	■ Rhinosinusitis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Sinonasal Inflammatory Polyps
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Paranasal Sinus Mucocele
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Allergic Fungal Sinusitis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Nasal Glial Heterotopia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Rhinoscleroma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Rhinosporidiosis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Granulomatosis With Polyangiitis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Sinonasal Hamartomas
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Rhinosinusitis
		Sinonasal Inflammatory Polyps
		Paranasal Sinus Mucocele
		Glial Heterotopia
		Infections
		Granulomatosis With Polyangiitis (Wegener Granulomatosis)
		Sinonasal Hamartomas
2 Benign Neoplasms of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx
	■ Sinonasal Papillomas
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
				Exophytic Papilloma
				Inverted Papilloma
				Oncocytic Cell Papilloma
		Ancillary Studies
			Immunohistochemical Findings
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Lobular Capillary Hemangioma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Meningioma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Glomangiopericytoma (Sinonasal- Type Hemangiopericytoma)
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Genetic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Nasopharyngeal Angiofibroma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Ectopic Pituitary Adenoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Sinonasal Papillomas
		Lobular Capillary Hemangioma (Pyogenic Granuloma)
		Meningioma
		Glomangiopericytoma (Hemangiopericytoma)
		Nasopharyngeal Angiofibroma
		Pituitary Adenoma
3 Malignant Neoplasms of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx
	■ Squamous Cell Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Sinonasal Adenocarcinoma
		Clinical Features
			Salivary Gland–Type Adenocarcinoma
			Non–Salivary Gland–Type Adenocarcinoma
		Pathologic Features
			Gross Findings
			Microscopic Findings
				Salivary Gland–Type Adenocarcinoma
				Non–Salivary Gland–Type Adenocarcinoma
					Intestinal-Type Adenocarcinoma.
					Nonintestinal-Type Adenocarcinoma.
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Sinonasal Undifferentiated Carcinoma (SNUC)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Nut Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Nasopharyngeal Carcinoma
		Clinical Features
		Radiographic Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
				Nonkeratinizing Squamous Cell Carcinoma
				Keratinizing Squamous Cell Carcinoma
				Basaloid Squamous Cell Carcinoma
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Mucosal Melanoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Olfactory Neuroblastoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Histochemistry Findings
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Extranodal NK/T-Cell Lymphoma, Nasal Type
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical Studies
			Immunohistochemical Findings
			Molecular Genetics
		Differential Diagnosis
		Prognosis and Therapy
	■ Mesenchymal Malignancies
	Rhabdomyosarcoma
	Fibrosarcoma
	Biphenotypic Sinonasal Sarcoma
	Leiomyosarcoma
	Angiosarcoma
	■ Ewing Sarcoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical Studies
			Immunohistochemical Findings
			Molecular Genetics
		Differential Diagnosis
		Prognosis and Therapy
	■ Teratocarcinosarcoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Squamous Cell Carcinoma
		Sinonasal Adenocarcinoma
		Sinonasal Undifferentiated Carcinoma
		NUT Carcinoma
		Nasopharyngeal Carcinoma
		Malignant Mucosal Melanoma
		Olfactory Neuroblastoma
		Extranodal NK/T-Cell Lymphoma, Nasal Type
		Rhabdomyosarcoma
		Biphenotypic Sinonasal Sarcoma
		Fibrosarcoma
		Leiomyosarcoma
		Angiosarcoma
		Ewing Sarcoma
		Teratocarcinosarcoma
4 Non-Neoplastic Lesions of the Larynx, Hypopharynx, and Trachea
	■ Vocal Cord Polyps and Nodules
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Contact Ulcer
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Amyloidosis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Special Stains
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Cysts of the Larynx (Including Laryngocele)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Reactive Epithelial Changes
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Reading
	Suggested Reading
		Vocal Cord Polyps and Nodules
		Contact Ulcer
		Amyloidosis
		Cysts of the Larynx (Including Laryngocele)
		Reactive Epithelial Changes
5 Benign Neoplasms of the Larynx, Hypopharynx, and Trachea
	■ Squamous Papillomas
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Granular Cell Tumor
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Adult Rhabdomyoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Chondroma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Inflammatory Myofibroblastic Tumor
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Squamous Papilloma/Papillomatosis
		Granular Cell Tumor
		Adult Rhabdomyoma
		Chondroma
		Inflammatory Myofibroblastic Tumor
6 Malignant Neoplasms of the Larynx, Hypopharynx, and Trachea
	■ Precursor Squamous Lesions
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Squamous Cell Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	Variants of Squamous Cell Carcinoma
		Verrucous Squamous Cell Carcinoma
		Exophytic and Papillary Squamous Cell Carcinoma
		Spindle Cell Squamous Cell Carcinoma
		Basaloid Squamous Cell Carcinoma
		Adenosquamous Carcinoma
	■ Neuroendocrine Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Chondrosarcoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Metastatic/Secondary Tumors
		Clinical Features
		Pathologic Features
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Treatment
	Suggested Readings
	Suggested Readings
		Precursor Lesions
		Squamous Cell Carcinoma and Variants
		Neuroendocrine Carcinoma
		Chondrosarcoma
		Metastatic – Secondary Tumors
7 Non-Neoplastic Lesions of the Oral Cavity
	■ Fordyce Granules
		Clinical Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	■ Amalgam Tattoo
		Clinical Features
		Radiographic Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	■ Ectopic Thyroid
		Clinical Features
		Radiographic Features
		Pathologic Features
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Oral Hairy Leukoplakia
		Clinical Features
		Pathologic Features
			Histochemical Studies
			Immunohistochemical Findings
			Molecular Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Infections
		Clinical Features
		Pathologic Features
			Candida (Including Median Rhomboid Glossitis)
			Herpes Simplex Virus 1
			Actinomycosis
		Differential Diagnosis
		Prognosis and Therapy
	■ Oral Lichen Planus
		Clinical Features
		Pathologic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Mucous Membrane Pemphigoid
		Clinical Features
		Pathologic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Pemphigus Vulgaris
		Clinical Features
		Pathologic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Recurrent Aphthous Stomatitis
		Clinical Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	■ Traumatic Ulcerative Granuloma
		Clinical Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Fordyce Granules
		Amalgam Tattoo
		Ectopic Thyroid
		Oral Hairy Leukoplakia
		Infections
		Oral Lichen Planus
		Mucous Membrane Pemphigoid
		Pemphigus Vulgaris
		Recurrent Aphthous Stomatitis
		Traumatic Ulcerative Granuloma
8 Benign Neoplasms of the Oral Cavity
	■ Fibroma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Squamous Papilloma (Including Verruca and Condyloma)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Multifocal Epithelial Hyperplasia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Lobular Capillary Hemangioma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Peripheral Ossifying Fibroma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Peripheral Giant Cell Granuloma
		Clinical Features
		Radiographic Features
		Pathologic FFeatures
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Granular Cell Tumor
		Clinical FFeatures
		Pathologic FFeatures
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Congenital Granular Cell Epulis
		Clinical Features
		Pathologic FFeatures
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Ectomesenchymal Chondromyxoid Tumor
		Clinical FFeatures
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Fibroma
		Squamous Papilloma (Including Verruca and Condyloma)
		Multifocal Epithelial Hyperplasia
		Lobular Capillary Hemangioma
		Peripheral Ossifying Fibroma
		Peripheral Giant Cell Granuloma
		Granular Cell Tumor
		Congenital Epulis
		Ectomesenchymal Chondromyxoid Tumor
9 Malignant Neoplasms of the Oral Cavity
	■ Squamous Cell Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Kaposi Sarcoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Oral Mucosal Melanoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Squamous Cell Carcinoma
		Kaposi’s Sarcoma
		Oral Mucosal Melanoma
10 Malignant Neoplasms of the Oropharynx
	■ Squamous Cell Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Small Cell Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Squamous Cell Carcinoma
		Small Cell Carcinoma
11 Non-Neoplastic Lesions of the Salivary Glands
	■ Developmental Lesions, Including Heterotopia and Oncocytosis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Histochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Mucus Retention Cyst, Mucocele, and Sialolithiasis
		Clinical Features
		Radiographic Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	■ Necrotizing Sialometaplasia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Lymphoepithelial Sialadenitis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Lymphoepithelial Cyst
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Sclerosing Polycystic Adenosis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Intercalated Duct Hyperplasia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Developmental Lesions, Including Heterotopia and Oncocytosis
		Mucus Retention Cyst, Mucocele, and Sialolithiasis
		Necrotizing Sialometaplasia
		Lymphoepithelial Sialadenitis
		Lymphoepithelial Cyst
		Sclerosing Polycystic Adenosis
		Intercalated Duct Hyperplasia
12 Benign Neoplasms of the Salivary Glands
	■ Pleomorphic Adenoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Basal Cell Adenoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Canalicular Adenoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Oncocytoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical Findings
			Ultrastructural Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Warthin Tumor
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Sebaceous Adenoma/Lymphadenoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Hemangioma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Pleomorphic Adenoma
		Basal Cell Adenoma
		Canalicular Adenoma
		Oncocytoma
		Warthin Tumor
		Sebaceous Adenoma/Lymphadenoma
		Hemangioma
13 Malignant Neoplasms of the Salivary Glands
	■ Mucoepidermoid Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Tumor Grading
		Ancillary Studies
			Immunohistochemical Findings
			Molecular Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Acinic Cell Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Adenoid Cystic Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical and Immunohistochemical Findings
			Molecular Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Polymorphous Adenocarcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Epithelial-Myoepithelial Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Secretory Carcinoma (Mammary Analogue Secretory Carcinoma)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Tumor Grading
		Ancillary Studies
			Immunohistochemical Findings
			Molecular Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Salivary Duct Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Carcinoma Ex Pleomorphic Adenoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Extranodal Marginal Zone B-Cell Lymphoma of Salivary Glands
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Sialoblastoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Uncommon Carcinomas
		Basal Cell Adenocarcinoma
		Clear Cell Carcinoma
		Sebaceous Adenocarcinoma
		Oncocytic Carcinoma
	■ Undifferentiated Carcinomas
		Small Cell Carcinoma
		Large Cell Carcinoma
		Lymphoepithelial Carcinoma
	■ Adenocarcinoma, Not Otherwise Specified
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Mucoepidermoid Carcinoma
		Acinic Cell Carcinoma
		Adenoid Cystic Carcinoma
		Polymorphous Adenocarcinoma
		Epithelial-Myoepithelial Carcinoma
		Secretory Carcinoma
		Salivary Duct Carcinoma
		Carcinoma ex Pleomorphic Adenoma
		Extranodal Marginal Zone B-Cell Lymphoma of Salivary Glands
		Sialoblastoma
		Uncommon Carcinomas
		Undifferentiated Carcinomas
		Adenocarcinoma Not Otherwise Specified
14 Non-Neoplastic Lesions of the Gnathic Bones
	■ Osteomyelitis
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Dentigerous Cyst
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Periapical Cyst/Granuloma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Fibrous Dysplasia
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Osteonecrosis
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Simple (Solitary) Bone Cyst
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Nasopalatine Duct Cyst
		Clinical Features
		Radiographic Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	■ Tori
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Cherubism
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Cemento-Osseous Dysplasia
		Clinical Features
		Radiograhic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Osteomyelitis
		Dentigerous Cyst
		Periapical Cyst/Granuloma
		Fibrous Dysplasia
		Osteonecrosis
		Nasopalatine Duct Cyst
		Simple Bone Cyst
		Tori
		Cherubism
		Osseous Dysplasia
15 Benign Neoplasms of the Gnathic Bones
	■ Ossifying Fibroma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Juvenile Ossifying Fibroma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Central Odontogenic Fibroma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Osteoblastoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Osteoid Osteoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Cementoblastoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Ameloblastoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Odontogenic Keratocyst
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Calcifying Epithelial Odontogenic Tumor
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Adenomatoid Odontogenic Tumor
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Central Giant Cell Lesion
		Clinical Features
		Radiographic Features
		Pathologic Features
		Differential Diagnosis
		Prognosis and Therapy
	■ Odontoma (Complex and Compound)
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Ossifying Fibroma
		Juvenile/Active Ossifying Fibroma
		Osteoblastoma
		Cementoblastoma
		Ameloblastoma
		Odontogenic Keratocyst
		Calcifying Epithelial Odontogenic Tumor
		Adenomatoid Odontogenic Tumor
		Central Giant Cell Lesion
		Odontoma
16 Malignant Neoplasms of the Gnathic Bones
	■ Osteosarcoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Chondrosarcoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Mesenchymal Chondrosarcoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Ameloblastic Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Primary Intraosseous Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Sclerosing Odontogenic Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Clear Cell Odontogenic Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Ghost Cell Odontogenic Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Odontogenic Sarcoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Osteosarcoma
		Chondrosarcoma
		Mesenchymal Chondrosarcoma
		Ameloblastic Carcinoma
		Primary Intraosseous Carcinoma
		Sclerosing Odontogenic Carcinoma
		Clear Cell Odontogenic Carcinoma
		Ghost Cell Odontogenic Carcinoma
		Odontogenic Carcinosarcoma
17 Non-Neoplastic Lesions of the Ear and Temporal Bone
	■ First Branchial Cleft Anomalies
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Cystic Chondromalacia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Chondrodermatitis Nodular Helicis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Angiolymphoid Hyperplasia With Eosinophilia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Relapsing Polychondritis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Cholesteatoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Cholesterol Granuloma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		First Branchial Cleft Anomalies
		Cystic Chondromalacia
		Chondrodermatitis Nodular Helicis
		Angiolymphoid Hyperplasia With Eosinophilia
		Relapsing Polychondritis
		Cholesteatoma
		Cholesterol Granuloma
18 Benign Neoplasms of the Ear and Temporal Bone
	■ Ceruminous Adenoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Langerhans Cell Histiocytosis
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemistry
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Peripheral Nerve Sheath Tumor (Schwannoma)
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Genetic Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Paraganglioma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Genetic Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Meningioma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Middle Ear Adenoma (Neuroendocrine Adenoma of the Middle Ear)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Histochemical Findings
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Endolymphatic Sac Tumor
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Genetic Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Ceruminous Adenoma
		Langerhans Cell Histiocytosis
		Peripheral Nerve Sheath Tumor (Schwannoma)
		Paraganglioma
		Meningioma
		Middle Ear Adenoma
		Endolymphatic Sac Tumor
19 Malignant Neoplasms of the Ear and Temporal Bone
	■ Squamous Cell Carcinoma (External Auditory Canal and Middle Ear)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Ceruminous Adenocarcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Metastatic Neoplasms
		Clinical Features
		Pathologic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Squamous Cell Carcinoma (External Auditory Canal and Middle Ear)
		Ceruminous Adenocarcinoma
		Metastatic Neoplasms
20 Non-Neoplastic Lesions of the Neck (Soft Tissue, Bone, and Lymph Node)
	■ Branchial Cleft Anomalies
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Cat Scratch Disease (Granulomatous Inflammation)
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical Findings
			Fine Needle Aspiration
			Immunohistochemical Findings
			Additional Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Bacillary Angiomatosis
		Clinical Features
		Pathologic Features
			Microscopic findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Cervicofacial Actinomycosis
		Clinical Features
		Radiographic Features
		Pathologic Features
			Microscopic Findings
			Special Techniques
		Prognosis and Therapy
	■ Nodular Fasciitis
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
			Molecular Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Sinus Histiocytosis With Massive Lymphadenopathy (Rosai-Dorfman Disease)
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Langerhans Cell Histiocytosis
		Clinical Features
		Radiographic Features
		Pathologic Features
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Branchial Cleft Anomalies
		Cat Scratch Disease (Granulomatous Inflammation)
		Bacillary Angiomatosis
		Cervical Actinomycosis
		Nodular Fasciitis
		Sinus Histiocytosis With Massive Lymphadenopathy (Rosai-Dorfman Disease)
		Langerhans Cell Histiocytosis
21 Benign Neoplasms of the Neck (Soft Tissue, Bone, and Lymph Node)
	■ Lymphangioma (Cystic Hygroma)
		Clinical Features
		Pathologic Features
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Teratoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Ectopic Hamartomatous Thymoma
		Clinical Features
		Pathological Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Spindle Cell Lipoma/ Pleomorphic Lipoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
			Fine Needle Aspiration
			Molecular Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Lymphangioma (Cystic Hygroma)
		Teratoma
		Ectopic Hamartomatous Thymoma
		Spindle Cell Lipoma/Pleomorphic Lipoma
22 Malignant Neoplasms of the Neck (Soft Tissue and Lymph Node)
	■ Metastatic Squamous Cell Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical and Molecular Findings
			Fine Needle Aspiration
		Differential Diagnosis
			Prognosis and Therapy
	■ Metastatic Neoplasm of Unknown Primary
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical and Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Synovial Sarcoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Chordoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Metastatic Squamous Cell Carcinoma
		Metastatic Neoplasm of Unknown Primary
		Synovial Sarcoma
		Chordoma
23 Non-Neoplastic Lesions of the Thyroid Gland
	■ Thyroglossal Duct Cyst
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Thyroid Ectopia and Lingual Thyroid
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Ultimobranchial Body Remnants (Solid Cell Nests) and Other Intrathyroidal Inclusions
		Clinical Features
		Pathologic Features
		Ancillary Studies
			Immunohistochemical Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Acute Thyroiditis
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Subacute Granulomatous Thyroiditis (De Quervain Thyroiditis)
		Clinical Features
		Radiographic Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Invasive Fibrous Thyroiditis (IgG4-Related Thyroiditis; Riedel Thyroiditis)
		Clinical Features
		Radiographic Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Chronic Lymphocytic Thyroiditis (Hashimoto Thyroiditis)
		Clinical Features
		Radiographic Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Diffuse Hyperplasia (Graves DISEASE)
		Clinical Features
		Radiographic Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Nodular Hyperplasia (Adenomatoid Nodules, Multinodular Goiter)
		Clinical Features
		Radiographic Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Dyshormonogenetic Goiter
		Clinical Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Amyloid Goiter
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Histochemical Findings
			Mass Spectrometry
		Differential Diagnosis
		Prognosis and Therapy
	■ Amiodarone-Induced Thyroid Disease
		Clinical Features
		Laboratory Studies
		Pathologic Features
			Gross Findings
		Microscopic Features
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Thyroglossal Duct Cyst
		Thyroid Ectopia and Lingual Thyroid
		Ultimobranchial Body Remnants (Solid Cell Nests) and Other Intrathyroidal Inclusions
		Acute Thyroiditis
		Subacute Granulomatous Thyroiditis (de Quervain Thyroiditis)
		Invasive Fibrous Thyroiditis (IgG4-Related Thyroiditis; Riedel Thyroiditis)
		Chronic Lymphocytic Thyroiditis (Hashimoto Thyroiditis)
		Diffuse Hyperplasia (Graves Disease)
		Adenomatoid Nodules (Multinodular Goiter)
		Dyshormonogenetic Goiter
		Amyloid Goiter
		Amiodarone-Induced Thyroid Disease
24 Benign Neoplasms of the Thyroid Gland
	■ Follicular Adenoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Intraoperative Frozen Section
			Genetics
		Differential Diagnosis
		Prognosis and Therapy
	■ Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Genetics
		Differential Diagnosis
		Prognosis and Therapy
	■ Hyalinizing Trabecular Tumor
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Teratoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Follicular Adenoma
		Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Findings (NIFTP)
		Hyalinizing Trabecular Tumor
		Teratoma
25 Malignant Neoplasms of the Thyroid Gland
	■ Papillary THYROID Carcinoma
		Clinical FEATURES
		Radiographic Features
		Pathologic FEATURES
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Histological Variants of Papillary Carcinoma
		Encapsulated Variant
		Follicular Variant
		Macrofollicular Variant
		Oncocytic Variant
		Clear Cell Variant
		Spindle Cell Variant
		Diffuse Sclerosing Variant
		Tall Cell Variant
		Columnar Cell Variant
		Solid Variant
		Cribriform-Morular Variant
		Hobnail Variant
		Papillary Carcinoma-Size Variation
	■ Follicular Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Frozen Section
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Undifferentiated Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Medullary THYROID Carcinoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Histochemical and Immunohistochemical Findings
			Fine Needle Aspiration
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Primary Thyroid Gland Lymphoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
		Prognosis and Therapy
	■ Uncommon Thyroid Neoplasms
		Mucoepidermoid Carcinoma
		Squamous Cell Carcinoma
		Thymic and Related Branchial Pouch Neoplasms
		Mesenchymal Tumors
	■ Metastatic Neoplasms
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
		Suggested Readings
	Suggested Readings
		Papillary Carcinoma (Including Variants)
		Follicular Carcinoma
		Undifferentiated (Anaplastic) Carcinoma
		Medullary Thyroid Carcinoma
		Primary Thyroid Lymphoma
		Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma With Eosinophilia
			Squamous Cell Carcinoma
			Spindle Cell Tumor With Thymus-Like Differentiation
			Carcinoma Showing Thymus-Like Differentiation
			Mesenchymal Tumors
		Metastatic Neoplasms
26 Non-Neoplastic Lesions of the Parathyroid Glands
	■ General Considerations
	■ Primary Chief Cell Hyperplasia
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
				Primary Chief Cell Hyperplasia
				Water-Clear Cell Hyperplasia
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	■ Secondary and Tertiary Parathyroid Hyperplasia
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Primary Chief Cell Hyperplasia
		Secondary and Tertiary Parathyroid Hyperplasia
27 Benign Neoplasms of the Parathyroid Gland
	■ Parathyroid Adenoma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Histochemistry
			Fine Needle Aspiration
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Parathyroid Adenoma
28 Malignant Neoplasms of the Parathyroid Gland
	■ Parathyroid Carcinoma
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Immunohistochemical Findings
			Molecular Findings
		Differential Diagnosis
		Prognosis and Therapy
	■ Metastatic Tumors
		Clinical Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Parathyroid Carcinoma
		Metastatic Tumors
29 Diseases of the Paraganglia System
	■ Paraganglioma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
			Ultrastructural Findings
			Immunohistochemical Findings
			Fine Needle Aspiration
		Differential Diagnosis
			Middle Ear/Jugulotympanic Paraganglioma
			Vagal and Carotid Body Tumors
			Laryngeal Paraganglioma
		Prognosis and Therapy
	■ Malignant Paraganglioma
		Clinical Features
		Radiographic Features
		Pathologic Features
			Gross Findings
			Microscopic Findings
		Ancillary Studies
		Differential Diagnosis
		Prognosis and Therapy
	Suggested Readings
	Suggested Readings
		Paraganglioma
		Malignant Paraganglioma
■ Index
	A
	B
	C
	D
	E
	F
	G
	H
	I
	J
	K
	L
	M
	N
	O
	P
	R
	S
	T
	U
	V
	W
	Z