Head and neck cancers : evidence-based treatment

Cover
Title
Copyright
Contents
Contributors
Preface
Share Head and Neck Cancers: Evidence-Based Treatment
Section I: Epidemiology, Biology, Diagnosis, and Staging
	Chapter 1: Head and Neck Cancer Epidemiology
		Nasopharyngeal Carcinoma
		Oropharyngeal Carcinoma
		Oral Cavity Carcinoma
		Larynx Cancer
		Salivary Gland Cancer
		References
	Chapter 2: Pathology of HNSCC
		Oral Premalignant Lesions
		Squamous Cell Carcinoma
		Cytologic Evaluation—FNA Biopsy
		Ancillary Studies in HNSCC
		References
	Chapter 3: The Genomic Landscape of HNSCC
		Cancer and Somatic Genetic Alterations
		Mutations, Copy Number Alterations, and Epigenetic Changes
		Drivers and Passengers
		Classification of HNSCC
		HPV-negative and HPV-positive HNSCC: Carcinogenesis
		HPV-negative and HPV-positive HNSCC: Protein Expression, Genetics, and Epigenetics
		HPV-negative and HPV-positive HNSCC: Altered Pathways
		Summary
		References
	Chapter 4: HPV-related Head and Neck Cancer Biology
		A Distinct Entity
		Prognosis of HPV-related HNSCC
		Trends in the Management of HPV-related OPC
		Trends in HPV-related OPC Staging
		Emerging Biomarkers
		Conclusions
		References
	Chapter 5: Imaging of Head and Neck Cancers
		Epidemiology
		Anatomy
		Head and Neck Tumors
		Imaging Modalities
		Value of Imaging
		Pretreatment Strategy
		Posttreatment Strategy
		Recent Advances
		Conclusions
		References
Section II: Established and Emerging Treatment Modalities
	Chapter 6: Advances in Radiation Therapy Techniques for HNSCC: Image-guided RT Stereotactic, IMRT-VMAT, MRI-Linac and Simulation
		Radiation Therapy Simulation
		Treatment Planning
		Treatment Delivery
		Conclusion
		References
	Chapter 7: Proton Therapy
		Physics and Treatment Planning
		Outcomes by Tumor Site and Treatment Setting
		Toxicity of Proton Therapy Relative to Other Treatment Options
		Patient Selection
		Cost-effectiveness and the Value of Proton Therapy
		Conclusions
		References
	Chapter 8: Transoral Robotic Surgery: Advances and Applications
		Transoral Robotic Surgery
		TORS for Oropharyngeal Cancer
		TORS for Cancer of the Unknown Primary
		TORS for Laryngeal Cancer
		TORS for Nasopharyngeal Cancer
		TORS for Parapharyngeal Space Tumors
		Controversies in TORS
		TORS in Clinical Trials
		Conclusions
		References
	Chapter 9: Induction Chemotherapy: Current and Emerging Role in HNSCC
		Induction Chemotherapy in the Setting of Larynx and Hypopharynx Preservation
		The Optimal Induction Chemotherapy Regimen
		Sequential Versus Concurrent Chemoradiotherapy in Locoregionally Advanced HNSCC
		Preoperative Induction Chemotherapy in Resectable, Oral Cavity HNSCC
		Alternatives to the Standard Induction Chemotherapy Regimen
		Current and Emerging Role
		References
	Chapter 10: Immunotherapy for HNSCC: Rationale and Clinical Applications
		Immunology of Cancer
		Mechanisms of Immune Escape in HNSCC and Rationale for Therapeutic Targets
		Targets of Immunotherapy in HNSCC
		The Rationale for Combination Therapies
		Clinical Data with Immune Checkpoint Inhibitors in Recurrent or Metastatic HNSCC
		Clinical Applications of Immunotherapy in Locally Advanced HNSCC
		Future Therapeutic Targets of Immunotherapy
		References
	Chapter 11: Targeting the Human Epidermal Receptor Family in HNSCC
		EGFR and HNSCC
		Cetuximab, the only Approved Monoclonal Antibody Targeting EGFR in HNSCC (Table 11.1)
		Anti-EGFR Therapies Beyond Cetuximab
		Conclusions
		References
	Chapter 12: Therapies Targeting VEGF/Angiogenesis and other Novel Targets and Therapies in HNSCC
		Vascular Endothelial Growth Factor (VEGF) and Angiogenesis in Cancer
		Prognostic Role of VEGF and Other Markers in HNSCC
		Clinical Evidence
		Novel Agents in HNSCC
		Combination of other Novel Agents with Radiation
		HDAC Inhibition and Radiation
		MET Inhibition and Radiation
		Conclusions
		References
Section III: Site-specific Management
	Chapter 13: Oropharyngeal Cancer: HPV-positive Disease
		Patient Selection for De-intensification Strategies
		HPV-associated Oropharynx Cancer Biology
		Radiation Dose De-escalation
		Response-adapted Volume De-escalation
		Chemotherapy De-escalation
		Intensification with Biologic Agents
		Surveillance Following Treatment in HPV Disease
		Minimally Invasive Surgery
		Role of Immunotherapy
		Conclusions
		References
	Chapter 14: Non–HPV-associated Oropharyngeal Cancer
		Background
		Epidemiology of HPV-negative OPSCC
		The Diagnosis of HPV-negative OPSCC
		Nonsurgical Treatment for HPV-negative OPSCC
		Modern Surgical Treatment of OPSCC
		Surgical Treatment of HPV-negative OPSCC
		Surgical Clinical Trials for HPV-negative OPSCC
		Surgical Salvage for HPV-negative OPSCC
		Molecular Markers and Novel Therapies in OPSCC
		Conclusions
		References
	Chapter 15: Oral Cavity Cancer: Surgical Approaches and Postoperative Treatment
		Epidemiology
		Etiology
		Immunosuppression
		Anatomy
		Pathology
		Evaluation
		Management
		Role of Induction Chemotherapy
		Role of Adjuvant Radiotherapy and Chemotherapy
		Outcomes and Surveillance
		References
	Chapter 16: Nasopharyngeal Cancer
		Case Summaries
		Evidence-based Case Discussion
		Induction Chemotherapy followed by Concurrent Chemoradiation
		Conclusions
		References
	Chapter 17: Hypopharyngeal Cancer: A Multidisciplinary Approach
		Presentation and Staging
		Treatment Considerations
		Treatment Modalities
		Treatment Selection
		Impression: T1N0M0, Stage I Hypopharyngeal SCC
		Impression: T4AN2BM0, Stage IV Hypopharyngeal SCC
		Impression: T3N2BM0, Stage IV Hypopharyngeal SCC
		Conclusions
		References
	Chapter 18: Laryngeal Cancer: Organ Preservation Strategies
		Radiation Therapy
		Surgery
		Combined Modality Approaches
		Follow-up Care and Salvage Surgery
		Functional Larynx Preservation and Quality of Life
		Conclusions
		References
	Chapter 19: Malignancies of the Paranasal Sinuses and Skull Base
		Perspectives
		Oncology
		Etiology
		Diagnosis
		Imaging
		Pathology
		Management
		Management of the Skull Base
		Skull Base Reconstruction
		Unresectable Lesions
		Management of the Neck
		Complications
		Nonsurgical Therapies
		Proton Beam Radiation
		Chemotherapy
		Prognosis
		Conclusions
		References
	Chapter 20: Evaluation and Treatment of Metastatic Lymphadenopathy from an Unknown Primary
		Clinical Evaluation
		Treatment Approaches
		Treatment of HPV-negative SCCUP
		Specific Considerations In P16/HPV-positive Disease
		Conclusions
		References
	Chapter 21: Salivary Gland Malignancies
		Epidemiology and Histology
		Diagnosis and Staging
		Principles of Surgical Management
		Principles of Radiation Therapy (RT)
		Principles of Systemic Therapy
		Conclusions
		References
Section IV: Recurrent or Metastatic Disease
	Chapter 22: Locally Recurrent HNSCC: Salvage Surgery, Reirradiation
		Scope of Problem
		Evaluation and Prognosis
		Management: General
		Management: Salvage Surgery
		Neck Dissection—Salvage Surgery for Regionally Recurrent or Persistent Disease
		Isolated Neck Reccurence
		Management: Reirradiation
		Management: Addition of Chemotherapy to Reirradiation
		Conclusions
		References
	Chapter 23: Recurrent or Metastatic HNSCC: Systemic Therapy
		Active Agents in HNSCC
		Current Treatment According to Clinical Setting
		Special Populations
		Prognostic/Predictive Factors
		Conclusions
		References
Section V: Supportive Care and Special Patient Groups
	Chapter 24: Oral Complications
		Oral Mucositis
		Hyposalivation and Xerostomia
		Oral Candidiasis
		Taste Changes
		Osteoradionecrosis
		Reduced Mouth Opening/Trismus
		Dental Caries
		Periodontal Disease
		Immunotherapy for HNC Cancer
		References
	Chapter 25: Dysphagia in Patients with Head and Neck Cancer
		Normal Swallowing
		Dysphagia in HNC: Risk and Associated Morbidities
		Evaluation of Dysphagia
		Management of Dysphagia
		Conclusions
		References
	Chapter 26: Quality of Life Assessment and Patient-reported Outcomes in Head and Neck Cancer
		Why Measure Quality of Life and Patient-reported Outcomes in HNC?
		Development and Scoring Methods of QOL Instruments
		Common QOL Instruments Used in HNC
		Other Symptomor Sitespecific QOL Instruments used in HNC
		QOL as a Prognostic Factor in HNC
		Impact of Radiation Therapy Technique on QOL
		Swallowing-related QOL in HNC
		Impact of IMRT on Swallowing-related QOL
		Impact of Surgery and Surgical Technique on Swallowing-related QOL
		Evaluation of Swallowing Pros on Recently Closed and Ongoing Prospective Trials
		Neck Dissection, Shoulder Function, and QOL
		Voice-related QOL in Patients with Laryngeal Cancer
		Integrating Web-based Platforms and Electronic Technology to Obtain QOL Assessments
		Integrating QOL Data into Clinical Practice
		Pros and HNC Survivorship
		Conclusions
		References
	Chapter 27: Management of Head and Neck Cancers in the Elderly
		Assessing the Elderly Patient
		Modalities of Therapy in the Elderly HNC Patient
		Future Directions
		Conclusions
		References
Index