Handbook on Immunosenescence: Basic Understanding and Clinical Applications

Handbook on Immunosenescence......Page 3
ISBN 9781402090622......Page 4
Preface......Page 5
C O N T E N T S......Page 7
contributors......Page 15
Part I : Methods and Models for Studying Immunosenescence......Page 32
1. The Immune Risk Profile and Associated Parameters  in Late Life: Lessons from the OCTO and NONA  Longitudinal Studies  Anders Wikby, Jan Strindhall and Boo Johansson......Page 34
2.   Lymphocytes Sub-Types and Functions in Centenarians    as Models for Successful Ageing    Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi,    Erika Roat, Roberta Ferraresi, Linda Bertoncelli, Lara Gibellini,    Elisa Nemes and Andrea Cossarizza.......Page 60
3.   Mouse Models and Genetics of Immunosenescence    Qing Yu, Jyoti Misra Sen and Dennis Taub......Page 94
4.   Insect Models of Immunosenescence    Jeff Leips.......Page 118
5.   Clonal Culture Models of T-cell Senescence    Graham Pawelec, Jürgen Kempf and Anis Larbi......Page 138
6.   Mouse Models of Influenza    Ian C. Brett and Bert E. Johansson......Page 148
7. A Transgenic Dwarf Rat Strain as a Tool for the Study  of Immunosenescence in Aging Rats and the Effect of Calorie  Restriction  Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu,  Haruyoshi Yamaza and Takuya Chiba......Page 162
8.    Mathematical Modeling of Immunosenescence: Scenarios,      Processes and Limitations      A. A. Romanyukha, S. G. Rudnev, T. A. Sannikova and A. I. Yashin......Page 176
T Cells......Page 196
9. Age, T-cell Homeostasis, and T-cell Diversity in Humans   David L. Lamar, Cornelia M. Weyand and Jörg J. Goronzy......Page 198
10. The Role of T-regulatory Cells in Immune Senescence   Paul Moss......Page 224
11. Age-related Changes in Subpopulations of Peripheral Blood   Lymphocytes in Healthy Japanese Population   Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa and   Katsuiku Hirokawa......Page 234
12. Age-associated T-cell Clonal Expansions (TCE) in vivo—   Implications for Pathogen Resistance: Cellular   Immunosenescence – T cells   Janko Nikolich-Zugich and Anna Lang......Page 250
13. T-cell Cycle and Immunosenescence: Role of Aging in the   T-cell Proliferative Behaviour and Status Quo Maintenance   Jacek M. Witkowski......Page 266
14.    Mismatch Repair System and Aging: Microsatellite Instability      in Peripheral Blood Cells of the Elderly and in the T-cell Clone      Longitudinal Model      Simona Neri and Erminia Mariani......Page 288
15. Activation-Induced Cell Death of T-Cells in Elderly   Ewa Sikora and Agnieszka Brzezi ska......Page 308
16.    CD8 Clonal Expansions in Mice: An Age-associated      Alteration of CD8 Memory T-cells      Eric T. Clambey, John W. Kappler and Philippa Marrack......Page 322
17.    Generation and Gene Expression of CD28-CD8 T-cells      in Human      Nan-ping Weng......Page 358
18.    Role of Regulatory Subsets During Aging      Piotr Trzonkowski......Page 374
B Cells......Page 410
19. Transcription Factors in Mature B-Cells During Aging   Daniela Frasca, Richard L. Riley and Bonnie B. Blomberg......Page 412
20.   B-Cell Repertoire Changes in Mouse Models of Aging     Jean L. Scholz, William J. Quinn III and Michael P. Cancro......Page 424
21.   B-Cells and Antibodies in Old Humans     Kate L. Gibson and Deborah K. Dunn-Walters......Page 446
Neutrophils......Page 468
22.   Neutrophil Granulocyte Functions in the Elderly     Peter Uciechowski and Lothar Rink......Page 470
23.   Signal Transduction Changes in fMLP, TLRs, TREM-1     and GM-CSF Receptors in PMN with Aging     Carl F. Fortin, Anis Larbi, Gilles Dupuis and Tamas Fulop......Page 488
24.   Synergistic Effects of Ageing and Stress on Neutrophil     Function     Janet M. Lord, Anna C. Phillips and Wiebke Arlt.......Page 506
Antigen Presenting Cells......Page 528
25.   Role of Dendritic Cells in Aging     Anshu Agrawal, Sudhanshu Agrawal and Sudhir Gupta......Page 530
26.   Phenotypic and Functional Changes of Circulating     Monocytes in Elderly     Lia Ginaldi and Massimo De Martinis......Page 542
NK and NKT Cells......Page 560
27.   NK Cells in Human Ageing     Raquel Tarazona, Inmaculada Gayoso, Corona Alonso,     M. Luisa Pita, Esther Peralbo, Javier G. Casado,     Beatriz Sánchez-Correa, Sara Morgado and Rafael Solana......Page 562
28.   Natural Killer Cells and Human Longevity     Hideto Tamura and Kiyoyuki Ogata......Page 576
29. The Effects of Age on CD1d-restricted NKT-cells and   Their Contribution to Peripheral T-cell Immunity   Douglas E. Faunce and Jessica L. Palmer.......Page 592
Stem Cells......Page 602
30.   Lympho-Hematopoietic Stem Cells and Their Aging     Hartmut Geiger and Gary Van Zant......Page 604
31.   Implications of Developmental Switches for Hematopoietic      Stem Cell Aging     Jens M. Nygren and David Bryder......Page 620
Genetics......Page 644
32. Associations of Cytokine Polymorphisms   with Immunosenescence   Elissaveta Naumova and Milena Ivanova......Page 646
33.   Cytokine Polymorphisms and Immunosenescence     Owen A. Ross, Kelly M. Hinkle and I. Maeve Rea......Page 662
34.   Role of TLR Polymorphisms in Immunosenescence     Carmela Rita Balistreri, Giuseppina Candore, Giuseppina     Colonna-Romano, Maria Paola Grimaldi, Domenico Lio,     Florinda Listì, Sonya Vasto, Letizia Scola and Calogero Caruso......Page 690
Receptors and Signal Transduction......Page 704
35.   Signal Transduction Changes in T-cells with Aging     Tamas Fulop, Gilles Dupuis, Carl Fortin and Anis Larbi......Page 706
36.   Molecular Signaling of CD95- and TNFR-Mediatedapoptosis     in Naïve and Various Memory Subsets of T-Cells     Sudhir Gupta and Ankmalika Gupta......Page 726
Mitochondria......Page 742
37.   Mitochondria and Immunosenescence     Pazit Beckerman and Arie Ben Yehuda.......Page 744
Proteasome......Page 758
38.   Proteasome Activity and Immunosenescence     Bertrand Friguet......Page 760
Cytokines......Page 782
39. Age-Related Changes in Type 1 and Type 2   Cytokine Production in Humans   Elizabeth M. Gardner and Donna M. Murasko.......Page 784
40.    Cytokine Expression and Production Changes in Very      Old Age      Susan E. McNerlan, Marilyn Armstrong,      Owen A. Ross and I. Maeve Rea......Page 802
Neuro......Page 814
41.    Neuro-Endocrine-Immune Network and its Age-Related Changes      K. Hirokawa and M. Utsuyama......Page 816
42.    Sex Hormones and Immunosenescence      Christian R. Gomez, Vanessa Nomellini and Elizabeth J. Kovacs......Page 830
43.    Glucocorticoids and DHEA: Do They Have a Role      in Immunosenescence?      Moisés E. Bauer, Cristina M. Moriguchi Jeckel,      Cristina Bonorino, Flávia Ribeiro and Clarice Luz......Page 864
Thymus......Page 894
44. Thymic Involution and Thymic Renewal   Frances T. Hakim......Page 896
Inflammation......Page 922
45.    Inflamm-Aging      L. Bucci, R. Ostan, M. Capri, S. Salvioli, E. Cevenini,      L. Celani, D. Monti and C. Franceschi......Page 924
46. Molecular and Cellular Aspects of Macrophage Aging   Carlos Sebastián, Jorge Lloberas and Antonio Celada......Page 950
Infection......Page 978
47. Aging and HIV Disease: Synergistic Immunological Effects?   Rita B. Effros.......Page 980
48.   Role of Immunosenescence in Infections and Sepsis     in the Elderly     Tamas Fulop, Steven Castle, Anis Larbi, Carl Fortin,     Olivier Lesur and Graham Pawelec......Page 996
49.   Beneficial and Detrimental Manifestations of Age     on CD8+ T-Cell Memory to Respiratory Pathogens     Jacob E. Kohlmeier, Kenneth H. Ely, Alan D. Roberts,     Eric J. Yager, Marcia A. Blackman and David L. Woodland......Page 1010
50.   HIV Infection as a Model of Accelerated Immunosenescence     Victor Appay and Delphine Sauce......Page 1028
Autoimmunity......Page 1058
51. Autoimmunity and Autoimmune Diseases in the Elderly   Ewa Bryl and Jacek M. Witkowski......Page 1060
52. Autoimmunity—Aging Mouse Model for Autoimmune Diseases   Yoshio Hayashi and Naozumi Ishimaru......Page 1084
53. Atherosclerosis—An Age-dependent Autoimmune Disease   B. Henderson, A. Rossmann, Ch. Mayerl, M. Wick and G. Wick......Page 1094
54.   Immuno-Inflammatory Athero-Arteriosclerosis Induced     by Elastin Peptides. Effect of Age     L. Robert and A. M. Robert......Page 1120
Cancer......Page 1148
55.   Aging, Immunity and Cancer     Claude Sportès and Frances T. Hakim......Page 1150
56.   Breast Cancer and Immunosenescence     Mauro Provinciali, Alessia Donnini, Arianna Smorlesi     and Cristina Gatti......Page 1170
57. Aging, Cancer and Apoptosis in Animal Models   and Clinical Settings   Masanobu Kitagawa and Katsuiku Hirokawa......Page 1196
58.   Her-2/neu Transgenic Mice for Evaluation of Immune     and Antitumor Responses Against Self-Tumor Antigens     in the Young and the Old     Joseph Lustgarten and Noweeda Mirza......Page 1220
59.   Cancer Immunotherapy and Aging: Lessons From the Mouse     Claudia Gravekamp.......Page 1248
Metabolic Syndrome......Page 1276
60.   Insulin Resistance, Chronic Inf lammation and the Link     with Immunosenescence     Dawn J. Mazzatti, Kavita Karnik, Radu C. Oita     and Jonathan R. Powell.......Page 1278
Neurodegenerative Diseases......Page 1304
61.   Decline of Immune Responsiveness:     A Pathogenetic Factor in Alzheimer’s Disease?     Elke Richartz-Salzburger and Niklas Koehler......Page 1306
Frailty......Page 1322
62.   Inflammatory Markers and Frailty     Sean X. Leng and Linda P. Fried......Page 1324
63.   CMV Infection and Frailty: Immunologic Consequences     and Disease Pathogenesis     George C. Wang and Jeremy Walston.......Page 1336
Osteoporosis......Page 1358
64.   Osteoporosis, Inflammation and Ageing     Lia Ginaldi, Lucia P. Mengoli and Massimo De Martinis......Page 1360
Nutrition......Page 1384
65.   Protein-Energy Malnutrition as a Determinant     for Immuno-Senescence     Anis Larbi, Bruno Lesourd and Tamas Fulop.......Page 1386
66.   Role of Zinc and Selenium in Oxidative Stress     and Immunosenescence: Implications for Healthy Ageing     and Longevity     Eugenio Mocchegiani and Marco Malavolta......Page 1398
Lipids......Page 1428
67.   Immunomoduation by Polyunsaturated Fatty Acids:     Impact on T-cell Functions and Signaling     Maximilian Zeyda and Thomas M. Stulnig......Page 1430
68.    Omega-3 Polyunsaturated Fatty Acids and Immunosenescence      Christopher A. Jolly and Sirisha Karri......Page 1454
69.    Effect of Intrinsic and Extrinsic Lipids on T-cell Signalling      Anis Larbi, Emilie Combet, Graham Pawelec and Tamas Fulop......Page 1468
Vaccination......Page 1484
70.    Effect of Anti-influenza      Vaccination on Immune System in the Elderly      Piotr Trzonkowski......Page 1486
71.    Immunosenescence Modulation by Vaccination      Janet E. McElhaney and Allan M. McGavin......Page 1518
Can Interventions to Influence Immunosenescence Succeed?......Page 1544
72.    Interleukin -7 and Immunorejuvenation      Wayne A. Mitchell and Richard Aspinall......Page 1546
73. Assessment of Age-related Decline of Immunological   Function and Possible Methods for Immunological   Restoration in Elderly   Katsuiku Hirokawa, Masanori Utsuyama, Yuko Kikuchi   and Masanobu Kitagawa......Page 1578
74. Thymic Regeneration in Mice and Humans Following   Sex Steroid Ablation   Anne Fletcher, Jessica Reiseger, Katerina Vlahos, Natalie Seach,   Jarrod Dudakov, Ann Chidgey and Richard Boyd......Page 1602
75.    Nutraceuticals and Immune Restoration in the Elderly      Barry W. Ritz and Elizabeth M. Gardner......Page 1642
76.    Gene Therapy and Immune Senescence      Jian Chen, Hui-Chen Hsu and John D. Mountz......Page 1660
77.    Perspectives: Is Immunosenescence Clinically Relevant?      Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa and      Graham Pawelec......Page 1678
Subject Index......Page 1680