Handbook of Forensic Drug Analysis

Front Cover......Page 1
HANDBOOK OF FORENSIC DRUG ANALYSIS......Page 4
Copyright Page......Page 5
CONTENTS......Page 6
FOREWORD......Page 10
PREFACE......Page 12
ABOUT THE AUTHORS......Page 17
1.1 Drug Classifications......Page 24
1.2 Collection of Evidence in Drug Cases (Documentation, Safety, Packaging, Custody)......Page 25
1.3 Laboratory Capabilities and Accreditation......Page 27
Definition of Terms......Page 32
References......Page 35
2.1 Introduction......Page 36
2.2 Radioimmunoassay (RIA)......Page 40
2.3 Enzyme Immunoassay (EMIT, ELISA, CEDIA, and other EIAs)......Page 41
2.4 Fluorescence Polarization Immunoassay (FPIA)......Page 47
2.5 Kinetic Interaction of Microparticles in Solution (KIMS)......Page 49
2.6 Onsite (Point-Of-Collection) Immunoassays......Page 51
2.7. Performance Characteristics and Quality Management Of Immunoassays......Page 54
References......Page 57
CHAPTER 3. CANNABIS : METHODS OF FORENSIC ANALYSIS......Page 66
3.1 Qualitative Seized-Drug Analysis of Cannabis, Hash, and Hash Oil: Current and Historical Perspectives......Page 67
3.2 Profiling—Provenance......Page 87
3.3 Immunoassays for the Detection of Cannabinoids in Biological Matrices......Page 103
3.4 Confirmation (Confirmatory Test) of Cannabinoids in Urine Specimens......Page 121
References......Page 153
CHAPTER 4. ANALYSIS OF THE HALLUCINOGENS......Page 176
4.0 Theoretical Basis......Page 177
4.1 Infrared Spectrometer Instrumentation......Page 179
4.2 Infrared Spectroscopy of Lysergic Acid Diethylamide (LSD)......Page 187
4.3 Infrared Spectroscopy of Phenylalkylamines......Page 188
4.4 Infrared Spectroscopy of Phencyclidine and Analogs......Page 191
4.5 Infrared Spectroscopy of Tryptamines......Page 193
4.6 Further Reading......Page 195
4.7 Theoretical Basis......Page 199
4.8 Mass Spectroscopy of Lysergic Acid Diethylamide (LSD)......Page 209
4.9 Mass Spectroscopy of Phenylalkylamines......Page 210
4.10 Mass Spectroscopy of Phencyclidine And Analogs......Page 212
4.11 Mass Spectroscopy of Tryptamines......Page 214
4.12 Further Reading......Page 218
References......Page 225
4.13 Theoretical Basis......Page 228
4.14 The NMR Experiment......Page 230
4.15 Phencyclidine and Related Substances......Page 240
4.16 MDA and Analogs......Page 243
4.17 Ergot and Other Indole Alkaloids......Page 250
4.18 Tryptamines......Page 252
References......Page 254
5.1 Introduction......Page 258
5.2 Origin of Cocaine Samples......Page 259
5.3 Noninstrumental Methods for Detection of Cocaine......Page 260
5.4 Trace and Instrumental Analysis......Page 270
References......Page 293
6.1 Introduction......Page 300
6.2 Preliminary Methods for Opiate Detection......Page 301
6.3 Isolation of Opiates From Biosamples......Page 307
6.4 Papaver Somniferum as a Source of Opiates......Page 313
6.5 Heroin and Associated Illicit Opiate Formulations......Page 319
6.6 Other Opiate Agonists......Page 344
6.7 Summary......Page 363
References......Page 365
7.1 Introduction......Page 380
7.2 Detection......Page 384
7.3 Qualitative Methods of Analysis......Page 385
7.4 Quantitative Methods of Analysis......Page 397
7.5 Comparative Analysis and Profiling......Page 438
7.6 Conclusion......Page 455
References......Page 456
8.1 Range of Operations in Clandestine Laboratories......Page 476
8.2 Manufacture of Methamphetamine......Page 501
8.3 Law Enforcement......Page 537
References......Page 555
INDEX......Page 568