Handbook of Cell-Penetrating Peptides, Second Edition (Pharmacology and Toxicology: Basic and Clinical Aspects)

Preface......Page 6
Editor......Page 10
Contributors......Page 12
Contents......Page 18
Part I\r Classes and Prediction of Cell-Penetrating Peptides......Page 24
Penetratins......Page 28
Tat-Derived Cell-Penetrating Peptides: Discovery, Mechanism of Cell Uptake, and Applications to the Delivery of Oligonucleotides......Page 52
Model Amphipathic Peptides......Page 66
Cell-Penetrating cis-g-Amino-L-Proline-Derived Peptides......Page 84
Prediction of Cell-Penetrating Peptides......Page 100
Part II Mechanisms of Cell-Penetrating Peptides......Page 110
Inverted Lipid Models: A Pathway for Peptide Internalization?......Page 112
Membrane Interactions of Cell-Penetrating Peptides......Page 132
Interactions of Cell-Penetrating Peptides with Model Membranes......Page 162
The Import Mechanism of Cationic Cell-Penetrating Peptides and Its Implications for the Delivery of Peptide Inhibitors of Signal......Page 184
Mechanisms of Cargo Delivery by Transportans......Page 206
Tat-Mediated Peptide/Protein Transduction In Vivo......Page 224
Proteoglycans as Endocytosis Receptors for CPPs......Page 242
Part III Functionality of Shuttling Proteins and Protein-Derived Peptides......Page 258
Cell Permeable Peptides and Messenger Proteins, from a Serendipitous Observation to a New Signaling Mechanism......Page 262
Pharmacology and In Vivo Efficay of Pepducins in Hemostasis and Arterial Thrombosis......Page 268
HOXB4 Homeoprotein Transfer Promotes the Expansion of Hematopoietic Stem Cells......Page 282
Applications of Cell-Penetrating Peptides as Signal Transduction Modulators......Page 296
SynB Vectors as Drug Carriers......Page 316
Part IV Applications of Cell-Penetrating Peptides in Gene Modulation and Protein Transport......Page 332
Peptide Conjugates of Oligonucleotide Analogs and siRNA for Gene Expression Modulation......Page 336
Lego-Like Strategy for Assembling Multivalent Peptide-Based Vehicles Able to Deliver Molecular Cargoes into Cells......Page 352
Mechanistic Insights into Guanidinium-Rich Transporters Entering Cells......Page 376
Cell-Penetrating Short Interfering RNAs and Decoy Oligonucleotides......Page 398
A Noncovalent Peptide-Based Strategy for Peptide and Short Interfering RNA Delivery......Page 410
Part V Selective Targeting to Tumors and Other Tissues with Cell-Penetrating Peptides: In Vivo Applications......Page 432
Selective Delivery to Vascular Addresses: In Vivo Applications of Cell-Type-Specifi Cell-Penetrating Peptides......Page 436
In Vivo Applications of Cell-Penetrating Peptides......Page 446
Intracellular Delivery of Nanoparticles with CPPs......Page 462
Strategies to Incorporate CPPs into Synthetic Viruses for Tumor-Targeted Gene Therapy......Page 478
Cell-Permeable PentaPeptides Derived from Bax-Inhibiting Peptide......Page 492
Cellular Uptake of Liposomal and Micellar Carriers Mediated by ApoE-Derived Peptides......Page 506
Imaging the Influx of Cell-Penetrating Peptides into the Cytosol of Individual Live Cells......Page 528
Microbial MembranePenetrating Peptides and Their Applications......Page 538
Part VI CPP Methods......Page 558
Design and Synthesis of Cell-Penetrating Peptides......Page 560
Toxicity Methods for Cell-Penetrating Peptides......Page 576
Methods to Study the Translocation of Cell-Penetrating Peptides......Page 590
Index......Page 612