Handbook of cannabis therapeutics : from bench to bedside

Cover......Page 1
Half Title......Page 2
Title Page......Page 4
Copyright Page......Page 5
Table of Contents......Page 6
About the Editors......Page 14
Contributors......Page 16
Foreword......Page 18
Introduction......Page 20
Part I: Historical Notes......Page 22
  Introduction......Page 24
  Results......Page 25
  Conclusion......Page 29
  Update......Page 31
 Chapter 2.Cognoscenti of Cannabis I: Jacques-Joseph Moreau (1804-1884)......Page 32
 Chapter 3.Cognoscenti of Cannabis II: Simeon Seth on Cannabis......Page 36
  Introduction......Page 42
  Absence of Mention......Page 43
  The Emergence of Cannabis......Page 44
  Appendix I: Passages Discussing Wild Cannabis PossiblyMisunderstood As Discussing Domesticated Cannabis......Page 59
  Appendix II: Cannabis in Veterinary Medicine......Page 60
  Update......Page 61
  Introduction......Page 62
  Cannabis History in England......Page 64
  The Modern Era......Page 68
  Update......Page 70
  Introduction......Page 72
  New Indications for Cannabinoid Pharmaceuticals......Page 75
  Cannabinoids and Neuroprotection......Page 76
  Forbidden Territories......Page 77
  Update......Page 82
Part II: Pharmacology and Pharmacokinetics......Page 86
  Introduction......Page 88
  Pharmacokinetics of Δ9-THC......Page 93
  Absorption......Page 94
  Distribution......Page 99
  Metabolism......Page 103
  Course of Plasma Concentration of THCand Metabolites......Page 106
  Elimination......Page 107
  Time Effect Relationship......Page 113
  Pharmacokinetics of Other Cannabinoids......Page 118
  Metabolic Interactions......Page 120
  Conclusion......Page 122
  Introduction......Page 136
  Mechanism of Action......Page 138
  Cannabinoid Receptors......Page 140
  Endocannabinoids......Page 141
  Toxicity......Page 144
  Psyche, Cognition and Behavior......Page 146
  Central Nervous Systemand Neurochemistry......Page 147
  Circulatory System......Page 149
  Some Other Organ Systems and Effects......Page 150
  Pharmacological Activityof THC Metabolites......Page 152
  Pharmacological Effectsof Other Cannabinoids......Page 154
  Tolerance and Dependency......Page 157
  Therapeutic Uses......Page 158
  Hierarchy of Therapeutic Effects......Page 159
  Basic Research Stage......Page 160
  Drug Interactions......Page 162
  Conclusions......Page 163
  Update......Page 184
  Introduction......Page 190
  Results and Discussion......Page 191
  Cannabinoids......Page 192
  Terpenoids......Page 197
  Flavonoids......Page 206
  Conclusions......Page 209
  Update......Page 220
Part III: Endocannabinoids and Cannabinoid Receptors......Page 224
  The Endocannabinoid System......Page 226
  Endocannabinoid Pharmacology: More ThanMeets the Eye......Page 228
  Levels of Endocannabinoids in Tissues: Physiologyand Pathology......Page 230
  New Drugs From the Endocannabinoid System: Curativeor Palliative?......Page 235
  Update......Page 244
 Chapter 11.Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System As a Trigger for Newborn Suckling......Page 246
  Interactions of the Endocannabinoid Systemwith Hormones Regulating Food Intake......Page 247
  Endocannabinoids in Food Substances......Page 248
  Developmental Aspects of the Endocannabinoid-CB1Receptor System......Page 249
  Blockade of CB1 Receptors in Newborn Mice......Page 250
  Mechanisms of the CB1 Receptor Blockade-InducedGrowth-Stunting Effects......Page 252
  Conclusions......Page 253
  Update......Page 257
Part IV: Medicinal Uses......Page 260
  Introduction......Page 262
  Indications with Evidence for Medical Efficacy......Page 264
  Indications with Sparse Evidence of Efficacy......Page 272
  Discussion......Page 276
  Conclusion......Page 277
  Update......Page 282
 Chapter 13. Effects of Smoked Cannabis and Oral Δ9-Tetrahydrocannabinol on Nausea and Emesis After Cancer Chemotherapy: A Review of State Clinical Trials......Page 284
  Tennessee......Page 285
  Michigan......Page 286
  Georgia......Page 287
  New Mexico (1983)......Page 289
  New Mexico (1984)......Page 290
  California......Page 291
  New York......Page 292
  Discussion......Page 294
  Update......Page 297
 Chapter 14.Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat?......Page 300
  HG, Its Medicalization, and the Survivors......Page 301
  Cannabis, Pregnancy, and HG......Page 307
  Two Women’s Stories of Using Folk,Alternative Medicine......Page 312
  Conclusion......Page 316
  Update......Page 321
  AIDS in the United States......Page 322
  Cannabinoids as Antiemetic and Appetite Stimulantin AIDS Wasting Syndrome......Page 324
  Case Reports (The Patients’ Perspective)......Page 325
  Cannabis and Harm Reduction Strategies for Personswith AIDS......Page 327
  Conclusion......Page 330
  Update......Page 332
  The Ancient World and Medieval Middle and Far East......Page 334
  European and Western Medicine......Page 337
  Modern Ethnobotany of Cannabis in Obstetricsand Gynecology......Page 350
  Recent Theory and Clinical Data......Page 353
  Discussion and Conclusions......Page 357
  Update......Page 364
 Chapter 17.Crack Heads and Roots Daughters: The Therapeutic Use of Cannabis in Jamaica......Page 366
  Ganja......Page 367
  Cocaine......Page 369
  Women and Crack......Page 370
  Conclusions......Page 376
  Implications......Page 377
  Update......Page 379
  Introduction......Page 382
  Treatment Options: Acute Episodes, Disease Modificationand Symptom Management......Page 383
  Cannabis in Acute Treatment and Disease Modification......Page 384
  Cannabis in Symptom Management......Page 386
  Impaired Mobility: Spasticity......Page 387
  Nystagmus......Page 388
  Fatigue......Page 389
  Bladder Dysfunction......Page 390
  Discussion......Page 391
  Conclusions......Page 392
  Update......Page 396
Part V: Side Effects......Page 400
  Introduction......Page 402
  Cannabis Was a Medicine in the United States......Page 404
  Cannabis As a Harm Reduction Medicine......Page 405
  Cannabis As a Social/Recreational Drug......Page 408
  Cannabis Prohibition Causes More Harm Than the Drug......Page 412
  Conclusions......Page 415
 Chapter 20. Chronic Cannabis Use in the CompassionateInvestigational New Drug Program: An Examinationof Benefits and Adverse Effects of Legal ClinicalCannabis......Page 418
  Previous Chronic Cannabis Use Studies......Page 419
  A Brief History of the Compassionate IND......Page 420
  Methods......Page 422
  Results And Discussion......Page 423
  Conclusions and Recommendations......Page 461
  Update......Page 466
Afterword......Page 468
Index......Page 470