H-2 Antigens: Genes, Molecules, Function

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Recollections....Pages 3-5
Peter Gorer Could Discover the H-2 Complex by Naturally Occurring Human Antibodies....Pages 7-10
Tribute to George D. Snell....Pages 11-12
Brother Juniper’s Inconclusive Experiment: A Poetic History of the H-2 Complex....Pages 13-28
Front Matter....Pages 29-29
The Major Histocompatibility Complex of the BALB/C Mouse: Gene Organization and Recombination....Pages 31-39
Recombination Sites within the I Region of the Mouse H-2 Complex....Pages 41-47
Genetic Organization of the Qa and Tla Regions: Gene Mapping Based on the Analysis of Recombinant Strains....Pages 49-60
Origins of H-2 Polymorphism....Pages 61-76
The Relative Contributions of Gene Conversion-Like Substitutions and Unique Mutations Toward Polymorphism Among MHC Class I Genes....Pages 77-88
Can Heterozygote Advantage Account for the Maintenance of H-2 Polymorphisms....Pages 89-102
Hemopoietic Histocompatibility (Hh-1) Antigens: Polymorphism and Mapping....Pages 103-123
Involvement of the H-2 Complex in Steroid Hormone Metabolism....Pages 125-132
Some Recent Data on the Q-Subregion Genes and Their Products....Pages 133-138
The Evolution of MHC Class II Genes within the Genus Mus ....Pages 139-153
Front Matter....Pages 155-155
Toward an Understanding of the Biochemical Nature of H-2 Molecules: A Historical Perspective....Pages 157-168
The Analysis of H-2 Mutants: Molecular Genetics and Structure/Function Relationships....Pages 169-176
Site Directed Mutagenesis Identifies Allo-Antigenic Epitopes of an H-2 Antigen Recognized by Antibodies and by Cytotoxic T-Lymphocytes....Pages 177-184
Transacting Nuclear Proteins That Bind to the Upstream Regulatory Region of a MHC Class I Gene....Pages 185-190
The Previously Defined R d Class I Molecule is a Non-ß 2 M Associated Conformational Variant of L d ....Pages 191-200
Regulatory Elements in the Promoter of the H-2D d Class I Gene....Pages 201-208
Front Matter....Pages 155-155
Mutation of the Splice Acceptor Sites at the 5’End of Exon 2 of H-2K d and H-2D d Results in the Expression of Altered Class I Antigens Expressed on the Membrane of L Cells....Pages 209-218
Complex Expression of the Mouse H-2 Class I Genes....Pages 219-232
Biochemical and Molecular Characterization of Q-Region Class I Gene Products....Pages 233-244
Structural and Functional Analysis of Murine Class II Molecules....Pages 245-253
Transgenic Mice: New Systems for Studying the Function of MHC Class II Molecules....Pages 255-265
Activation of I-A Gene Products by A ß Gene Transfection Using Bovine Papilloma Virus — Vector Systems....Pages 267-273
Regulation of MHC Class II and Interleukin-1 Gene Expression in Differentiating Macrophages....Pages 275-281
Macrophage IA Hybrid Molecule as Product of the Ir-Thy-1 Genes....Pages 283-296
Probing MHC DNA in Search of Coding Sequences: Detection of a Novel Gene Located Between C4 and Bf in Mouse and Man....Pages 297-304
Mutation in the A β Gene of B6.C-H-2 bm12 . Antibody Binding Site VS. T Cell Recognition Sites....Pages 305-314
Cloning of a Testis-Specific Gene Located Between Qa -2 and Upg-1 on Mouse Chromosome 17....Pages 315-320
The End of H-2 ....Pages 321-325
Front Matter....Pages 327-338
Historical Developments in Understanding the Function of Class I MHC Genes....Pages 339-339
A Q Region Product as a CTL Restriction Element?....Pages 341-358
An H-2 Linked Gene, PED , Influences the Timing of Early Mouse Embryo Development....Pages 359-369
Associations Between Class I MHC Antigens and Viral Glycoproteins Detected by Fluorescence Resonance Energy Transfer....Pages 371-378
Mixed Bone Marrow Chimeras as an Approach to Transplantation Tolerance....Pages 379-384
Role of H-2 Antigen Induction in the Rejection of Thyroid and Pancreatic Islet Allografts....Pages 385-390
Control of Self Reactive CTL Independent of Thymic Selection....Pages 391-407
Front Matter....Pages 409-413
Role of MHC Class I Antigens in Tumor Rejection....Pages 339-339
Genetic Control of Interaction Between Class I and Class II Antigens in Murine Islet Rejection....Pages 415-428
I-J: An Inducible Isomorphic Receptor Involved in the H-2-Restricted Cell Interaction and Inhibition....Pages 429-434
Recognition of MHC Class II Antigens by the CD4: T Cell Receptor Complex....Pages 435-440
Epitopes of I-A k Involved in Antigen Presentation to T-Cell Hybridomas....Pages 441-449
Molecular Analysis of Major Histocompatibility Complex (MHC) Molecule Recognition by the T Cell Receptor Alpha-Beta (α-β) Heterodimer....Pages 451-463
The Major Histocompatibility Complex and the T Cell Repertoire....Pages 465-477
The Presentation of Processed, Ia Restricted, T Cell Antigenic Peptides on Antigen Presenting Cell Surfaces....Pages 479-484
Visualization of Direct T-B Cell Interaction....Pages 485-492
A Role for Ia Antigens in B Cell Activation: Studies with Normal B Cells and A B Cell Lymphoma....Pages 493-500
The Class II Molecule as a Signal Transducer to the B Cell: Cellular and Molecular Approaches....Pages 501-515
The Origin of Lyt-2 + Class II Specific Allogeneic CTL....Pages 517-522
Do Class II Major Histocompatibility Molecules Function as Signal Transducers during B Lymphocyte Activation?....Pages 523-530
Analysis of Antigen-Specific T Cell-Mediated Suppression at the Clonal Level....Pages 531-540
Autologous Mixed Lymphocyte Reaction Induced in Mice by Xenogeneic Immunization with Soluble HLA-DR Antigens....Pages 541-547
Ia Gene Expression in Non-Bone Marrow Derived Cells During Graft Vs Host Disease in the Mouse....Pages 549-557
Genetic Control of T-Cell and NK-Cell Protection Against Lethal Sendai Virus Infection....Pages 559-569
Front Matter....Pages 571-585
MHC Antigen Expression in Malignant Tumours and Their Effects on Host-Tumour Interaction....Pages 587-587
Class I Antigen Expression in Line 1 Cells: Molecular Biology and Immunological Effects....Pages 589-610
The Biological Implications of the Abnormal Expression of Histocompatibility Antigens on Murine and Human Tumors....Pages 611-622
Front Matter....Pages 623-639
Altered MHC Class I Genes Can Encode Immunogenic Antigens that Cause Tumor Rejection....Pages 587-587
Regulation of H-2 Class I Gene Expression in Virus Transformed and/or Infected Cells....Pages 641-650
Monoclonal H-2 Class I Specific Antibodies Isolated After Immunization of C57B1/6 Mice with Syngeneic Sendai Virus-Coated Cells....Pages 651-657
Analysis of Anti-Reovirus Cytotoxic T Lymphocytes (CTL) Using the H-2 dml Mutant....Pages 659-670
The H-2 Complex and the Hormonal Factors in Mammary Tumorigenesis in Mice....Pages 671-679
In Vivo Antitumor Effects of Anti-I-A Antibodies....Pages 681-689
Host-RCS Tumor Interactions in SJL/J Mice....Pages 691-697
The Role of Defective MHC Class I Expression for Tumor Growth and Metastasis....Pages 699-704
Front Matter....Pages 705-716
 H-2 -linked Control of the Susceptibility of Mice to Cleft Palate Induced by Cortisone and Testosterone....Pages 717-717
The Role of Immune Response Gene and I -A Molecule in Murine Myasthenia Gravis Pathogenesis....Pages 719-724
H-2 Genes in TMEV-Induced Demyelination, A Model for Multiple Sclerosis....Pages 725-733
The Contribution of MHC Gene Products to Demyelination by Theiler’s Virus....Pages 735-745
Expression of H-2 Genes and Susceptibility to Parasitic Infection....Pages 747-756
The Role of H-2 Gene Complex in Experimental Autoimmune Thyroiditis....Pages 757-767
Pristane-Induced Arthritis in Mice: Genetic Regulation and Immunity in an Experimental Model of Arthritis....Pages 769-778
Role of MHC Genes and T Cell Receptor Genes in Collagen Induced Arthritis in Mice....Pages 779-788
Front Matter....Pages 789-797
Use of Congenic and Recombinant Inbred Mouse Strains to Link a Highly Conserved Idiotype Marker to an Igh-C Region Allotype Locus and to Map This New Member of the Q52 Gene Family Within the Igh-V Gene Complex....Pages 799-799
Fc Receptor-Ligand Interaction Induces Activation of Human Natural Killer Cells....Pages 801-814
V Gene Diversity in the Memory Immune Response to PC-KLH....Pages 815-825
Immune Recognition of Human MHC DR2 Antigen....Pages 827-835
Back Matter....Pages 837-845
....Pages 847-850