GTPases in Biology I

Front Matter....Pages I-XLIII
Front Matter....Pages 1-1
GTPases Everywhere!....Pages 3-15
Proofreading in the Elongation Cycle of Protein Synthesis....Pages 17-30
A New Look at Receptor-Mediated Activation of a G-protein....Pages 31-38
Small GTPases and Vesicle Trafficking: Sec4p and its Interaction with Up- and Downstream Elements....Pages 39-52
Cytoskeletal Assembly: The Actin and Tubulin Nucleotidases....Pages 53-62
Dynamin, A Microtubule-Activated GTPase Involved in Endocytosis....Pages 63-73
Transmembrane Protein Translocation: Signal Recognition Particle and Its Receptor in the Endoplasmic Reticulum....Pages 75-85
GTPases and Actin as Targets for Bacterial Toxins....Pages 87-112
Front Matter....Pages 113-113
Eukaryotic Translation Factors Which Bind and Hydrolyze GTP....Pages 115-130
Heterotrimeric G-Proteins: α, β, and γ Subunits....Pages 131-149
Molecular Diversity in Signal Transducing G-Proteins....Pages 151-158
Structural Conservation of Ras-Related Proteins and Its Functional Implications....Pages 159-176
Conformational Switch and Structural Basis for Oncogenic Mutations of Ras Proteins....Pages 177-194
Structural and Mechanistic Aspects of the GTPase Reaction of H-ras p21....Pages 195-211
Analysis of Ras Structure and Dynamics by Nuclear Magnetic Resonance....Pages 213-234
Molecular Dynamics Studies of H- ras p21-GTP....Pages 235-245
Front Matter....Pages 247-247
The Discovery of ras and Its Biological Importance....Pages 249-258
Oncogenic Activation of Ras Proteins....Pages 259-287
Dominant Inhibitory Ras Mutants: Tools for Elucidating Ras Function....Pages 289-300
The Involvement of Cellular ras in Proliferative Signaling....Pages 301-321
Front Matter....Pages 247-247
Regulation of ras-Interacting Proteins in Saccharomyces cerevisiae ....Pages 323-334
Lipid Modifications of Proteins in the Ras Superfamily....Pages 335-344
GTPase Activating Proteins....Pages 345-359
Guanine Nucleotide Dissociation Stimulators....Pages 361-375
The Biology of Rap....Pages 377-393
GTPases and Interacting Elements in Vesicle Budding and Targeting in Yeast....Pages 397-407
Ypt Proteins in Yeast and Their Role in Intracellular Transport....Pages 409-421
Compartmentalization of rab Proteins in Mammalian Cells....Pages 423-445
GTPases in Transport Between Late Endosomes and the Trans Golgi Network....Pages 447-459
Endocytic Function in Cell-Free Systems....Pages 461-475
Synaptic Vesicle Membrane Traffic and the Cycle of Rab3....Pages 477-485
Regulated Exocytosis and Interorganelle Vesicular Traffic: A Comparative Analysis....Pages 487-505
Regulated and Constitutive Secretion Studied In Vitro: Control by GTPases at Multiple Levels....Pages 507-528
The Biology of ADP-Ribosylation Factors....Pages 529-541
Molecular Characterization of ADP-Ribosylation Factors....Pages 543-559
rho and rho-Related Proteins....Pages 563-577
The Mammalian Homolog of the Yeast Cell-Division-Cycle Protein, CDC42: Evidence for the Involvement of a Rho-Subtype GTPase in Cell Growth Regulation....Pages 579-595
Role of Rap1B and Its Phosphorylation in Cellular Function: A Working Model....Pages 599-612
GDP/GTP Exchange Proteins for Small GTP-Binding Proteins....Pages 613-624
GTP-Mediated Communication Between Intracellular Calcium Pools....Pages 625-649
Front Matter....Pages 247-247
Coupling of ras to the T Cell Antigen Receptor....Pages 651-659
GTPases as Regulators of Regulated Secretion....Pages 661-678
ADP-Ribosylation of Small GTPases by Clostridium botulinum Exoenzyme C3 and Pseudomonas aeruginosa Exoenzyme S....Pages 679-688
Back Matter....Pages 689-697