Growth Factors and Alzheimer’s Disease

Front Matter....Pages I-XV
Neurotrophic Factors and Neurodegenerative Diseases....Pages 1-14
Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells....Pages 15-28
Localizing Expression of the Three Members of the Nerve Growth Factor Family to Neurons in the Brain....Pages 29-38
Nerve Growth Factor: Studies Addressing Its Expression and Actions in the Central Nervous System....Pages 39-60
Nerve Growth Factor Gene Expression in Actively Growing Brain Glia....Pages 61-61
Human Nerve Growth Factor Receptor Expression in the CNS of Transgenic Mice....Pages 62-72
Involvement of Protein Kinase C in the Regulation of Nerve Growth Factor Synthesis: A Possible Cause of Impaired Trophic Supply in Alzheimer’s Disease?....Pages 73-80
Distribution and Characterization of β-Nerve Growth Factor Receptors in Alzheimer’s Disease....Pages 81-97
Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implications for the Treatment of Alzheimer’s Disease....Pages 98-105
Nerve Growth Factor Expression and Function in the CNS....Pages 106-116
Nerve Growth Factor and Behavioral Recovery After Brain Damage in Rats....Pages 117-130
Functional Impairments that Develop in Nerve Growth Factor-Sensitive Neuronal Projections in the PNS and CNS of Aged Rats Are Ameliorated by Dietary Interventions....Pages 131-148
Morphological and Behavioral Effects of Basic Fibroblast Growth Factor and Heparin on Transplanted Fetal Dopaminergic Neurons and Astrocytes in the Denervated Rat Caudate-Putamen....Pages 149-164
Acidic Fibroblast Growth Factor Localization and Basic Fibroblast Growth Factor Binding Sites in the Eye and Optic Nerve....Pages 165-174
Synthetic Peptide Agonists and Antagonists of Basic Fibroblast Growth Factor: Increasing Cellular Specificity of a Multifunctional Growth Factor....Pages 175-192
ACTH (4–10) Analog Potentiates Cognitive and Morphological Recovery After Frontal Cortex Lesions in Adult Rats....Pages 193-207
Effects of Neurotrophic Factors on the Secretion and Metabolism of the Alzheimer Amyloid Precursor....Pages 208-215
Nerve Growth Factor Induces Differential Splicing of β-Amyloid Precursor mRNAs in the PC 12 Cell Line....Pages 216-221
The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer’s Disease Pathology....Pages 222-233
The Neuritic Dystrophy of Alzheimer’s Disease: Degeneration or Regeneration?....Pages 234-240
Back Matter....Pages 241-244