Growth Factors, Peptides and Receptors

Front Matter....Pages i-x
Front Matter....Pages 1-1
Distribution of Endothelin, a Putative Growth Promoting Peptide, Using Modern Microscopical Imaging Methods....Pages 3-13
Vasoactive Intestinal Peptide: From Molecular Genetics to Neurotropism....Pages 15-20
Design and Structure/Conformation-Activity Studies of a Prototypic Corticotropin-Releasing Factor (CRF) Antagonist: Multiple Alanine Substitutions of CRF 12-41 ....Pages 21-28
Retinoic Acid Regulates preproVIP Expression in the Human Neuroblastoma Cell Line NB-1....Pages 29-35
Structure-Dependent Inhibitory Effect of Galanin on Insulin, Gastric Acid and Pancreatic Amylase Secretion in Rat....Pages 37-50
Amphibian Opioids: Novel Dermorphin-Like Peptides....Pages 51-60
Proteases for Neuropeptide Precursor Processing in Bovine Adrenal Medullary Chromaffin Granules....Pages 61-70
Amylin and Neuromedin U - Two Novel Regulatory Peptides of the Gastroenteropancreatic System....Pages 71-79
Front Matter....Pages 81-81
Gene Transfer into the Central Nervous System: Neurotrophic Factors....Pages 83-91
The Structural and Biological Properties of Heparin-Binding Egf- Like Growth Factor (HB-EGF)....Pages 93-100
Structural Organization of the Multiple Tgf- ßGenes....Pages 101-113
Dexamethasone Modulates the Response of Rat Stromal Bone Marrow Derived Bone-Like Cells to bFGF and Igf-I....Pages 115-126
Behavioral, Hormonal and Neurochemical Alterations in Transgenic Mice Overexpressing Transforming Growth Factorα....Pages 127-136
Growth Factors and Brain Injury....Pages 137-146
The Basic Fibroblast Growth Factor Isoforms: Endogenous and Exogenous Behavior....Pages 147-158
Front Matter....Pages 159-159
Structural Analysis of Ligand Binding Characteristics for the Bombesin/Gastrin-Releasing Peptide Receptor....Pages 161-170
Identification of Zeta ( S ) Opioid Receptor Binding Polypeptides in Rat Cerebellum....Pages 171-180
Identification and Characterization of Somatostatin (SRIF), Gastrin Releasing Peptide (GRP), and Neuromedin B (NMB) Receptors on Established Tumors and Tumor Cell Lines....Pages 181-188
Neuropeptide Receptor Sub-Types: Neuropeptide Y and Calcitonin-Gene Related Peptides as New Examples....Pages 189-198
Vasoactive Intestinal Peptide and Astrocyte Mitogenesis: In Vitro and in Vivo Studies....Pages 199-210
Front Matter....Pages 159-159
Synthesis and Biological Activity of Cholecystokinin Antagonists....Pages 211-223
Peptide-Neuromedin B (NMB) Receptor Interactions: Comparison with Gastrin-Releasing Peptide (GRP) Receptor Interactions....Pages 225-237
Front Matter....Pages 239-239
Neurotrophins in the Adult Brain: Effects on Hippocampal Cholinergic Function Following Deafferentation, and Regulation of Their Expression by Pharmacological Agents and Lesions....Pages 241-253
Angiosuppressive and Antiproliferative Actions of Suramin: A Growth Factor Antagonist....Pages 255-264
[ 125 I]IGF I, [ 125 I]IGF II and [ 125 I]Insulin Receptor Binding Sites in the Rat Hippocampal Formation: Topographic Distribution and Response to Entorhinal Ablation....Pages 265-277
Estrogen Regulation of the Pituitary Insulin - Like Growth Factor System....Pages 279-288
Effects of Radiofrequency Radiation on Growth Factor Receptors....Pages 289-296
Structure-Function Analysis of Fibroblast Growth Factor-1 (Acidic Fibroblast Growth Factor)....Pages 297-308
Front Matter....Pages 309-309
MDGF-1: A New Tyrosine Kinase-Associated Growth Factor....Pages 311-322
Interleukin-11 Mediated Signal Transduction Pathways: Comparison With Those of Interleukin-6....Pages 323-333
Regulation of a Membrane Tyrosine Phosphatase by Somatostatin....Pages 335-339
Cycloheximide Has Differing Effects on Immediate Early Gene Expression in IL-3 or M-CSF Stimulated Human Monocytes....Pages 341-345
Regulation of Gastrin Releasing Peptide Gene Expression....Pages 347-352
TGFα Induced Proliferative Changes in Transgenic Mice....Pages 355-366
Somatostatin and Human Gastrointestinal Cancer....Pages 367-379
Inhibition by Gnrh Antagonists of Breast and Endometrial Cancer Cell Growth Induced by Estrogen and Insulin-Like Growth Factors....Pages 381-387
Front Matter....Pages 353-353
ß-Endorphin is Metabolized in Vitro by Human Small Cell Lung Cancer to γ-Endorphin Which Stimulates Clonal Growth....Pages 389-400
The Role of EGF and Its Receptors in the Growth of Human Gastric Carcinoma Cell Line (MGC80): Evidence for an Autocrine Mechanism....Pages 401-407
The Single-Chain Immunotoxins BR96 sFv-PE40 and BR96 sFv-PE38: Potent Anti-Tumor Agents for the Treatment of Human Cancer....Pages 409-414
Front Matter....Pages 415-415
Hematopoietic Cytokines to Support Repeated Doses of Dose-Intensive Chemotherapy with Cyclophosphamide, Etoposide, and Cisplatin (DICEP)....Pages 417-424
Front Matter....Pages 415-415
Interleukin-2 (IL-2) Augments the Expression of Transforming Growth Factor Beta in Patients with Disseminated Cancer....Pages 425-433
Peptide Signals for Satiety....Pages 435-443
The Role of Somatostatin Receptors in the Diagnosis and Therapy of Cancer....Pages 445-460
Back Matter....Pages 461-467