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دانلود کتاب Green Approaches in Medicinal Chemistry for Sustainable Drug Design
دانلود کتاب رویکردهای سبز در شیمی دارویی برای طراحی داروی پایدار
مشخصات کتاب
Green Approaches in Medicinal Chemistry for Sustainable Drug Design
ویرایش: [1 ed.]
نویسندگان: Bimal K. Banik (editor)
سری: Advances in Green Chemistry
ISBN (شابک) : 0128175923, 9780128175927
ناشر: Elsevier Science Ltd
سال نشر: 2020
تعداد صفحات: 610
[1011]
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 46 Mb
قیمت کتاب (تومان) : 32,000
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توجه داشته باشید کتاب رویکردهای سبز در شیمی دارویی برای طراحی داروی پایدار نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
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فهرست مطالب
Copyright Contributors Editor's biography Preface Green chemistry assisted synthesis of natural and synthetic compounds as anticancer agents Introduction Natural products as anticancer agents Synthetic compounds as anticancer agents Conclusion References Antibacterial and antimicrobial coatings on metal substrates by cold spray technique: Present and future perspectives Introduction The need for the development of antibacterial and antimicrobial coatings The coating techniques Thermal spraying: Processes and techniques Cold spray: The process and its advantages Present status of the antibacterial and antimicrobial coating by cold spray Sustainability and cold spray technique Green aspects of cold spray Future prospects and concluding remarks Summary References Graphene oxide nanosheets as sustainable carbocatalysts: Synthesis of medicinally important heterocycles Introduction Strategies for the synthesis of medicinally important heterocyclic scaffolds using GO and CMGs Synthesis of substituted pyrroles and related heterocycles using GO nanosheets Synthetic approaches for quinazoline derivatives Multicomponent approach for the synthesis of substituted pyridine derivatives Synthesis of benzothiazines, benzothiazoles, imidazoles, and benzimidazoles Synthesis of functionalized quinoxalines Synthesis of 4H-pyrans, coumarins, chromenes, flavones, and xanthenes Synthesis of pyrimidones Catalytic processes for the synthesis of 1,2,3-triazoles References Sustainable green technologies for synthesis of potential drugs targeted toward tropical diseases Introduction Dose reduction through improved drug composition Green dose setting Reduction of cost through green chemistry Green chemistry in ARV therapy Green technology in malaria treatment Conclusion References Clay-mediated synthesis of biologically active molecules: Green and sustainable approaches Introduction Green and sustainable approach Basic principles of green chemistry Basic green methods for chemical synthesis Microwave-induced method Sonication method Biosynthetic method Clay minerals Classification of clay Clay-mediated synthesis of biologically active molecules Natural clay Montmorillonite K-10 clay Modified montmorillonite clay Modified montmorillonite K-10 clay Natural bentonite clay Modified bentonite clay Montmorillonite KSF clay Modified montmorillonite KSF clay Kaolin Modified kaolin Pillared clay Super acid clays Comparative study of montmorillonite-KSF and K-10 clays Conclusions Acknowledgment References Further reading The role of ionic liquid in medicinal chemistry Introduction Green chemistry and its requirements Green and alternative solvents in organic synthesis ILs and their synthesis Properties of ILs and their applications in green chemistry Green applications of ILs in medicinal chemistry ILs in synthesis of drugs and drug precursors ILs for extraction of bioactive natural products from plants Extraction of bioactive natural products through ultrasonic-assisted ionic liquid approach Extraction of bioactive natural products through microwave-assisted ionic liquid approach IL strategy for the reactive dissolution of biomass to extract natural ingredients ILs in the detection of pharmaceutically active compounds ILs for pharmaceutical crystallization ILs in pharmaceutical purification and separation Continuous pharmaceutical manufacturing using ILs Chromatographic purifications using ILs Biological activities of ILs Antimicrobial activities of ILs Antibiofilm activities of ILs Antiproliferative profile of ILs ILs as APIs The oligomeric methodology: Stoichiometric to nonstoichiometric API-ILs with protic ion Prodrug methodology Conclusion References Synthesis of medicinally important heterocycles inside the nanoreactors built-in nonconventional reaction media Introduction Surfactant and nanodimensional micelle Properties and uses of the nanoreactors Dehydration reaction in water for syntheses of medicinally important esters, ethers, and thioethers Cyclization reaction developed inside the nanoreactor to achieve bioactive heterocycles Oxidative cyclization Multicomponent reaction CC bond-forming reactions Carbon-heteroatom bond-forming reactions Povarov reaction Hydrolysis Click reaction Reduction strategies in water Halogenation Metal-catalyzed CC bond-forming reaction Conclusion References Further reading Green synthesis of nanoparticles and nanocomposites: Medicinal aspects Nanoparticles Nanocomposites Conclusion Acknowledgments References Use of sustainable organic transformations in the construction of heterocyclic scaffolds Introduction Organic transformations in deep eutectic solvents Synthesis of heterocyclic scaffolds Synthesis of pyrroles Synthesis of furans (naphthofurans) Synthesis of thiophenes Synthesis of pyrazoles Synthesis of pyranopyrazoles Synthesis of imidazoles Synthesis of substituted hydantoins Synthesis of isoxazoles Synthesis of oxazoles Synthesis of thiazoles Synthesis of thiazolidin-4-ones Synthesis of triazole derivatives Synthesis of pyridines Synthesis of 1,4-dihydropyridines Synthesis of imidazo[1,2-a]pyridines Synthesis of pyrazolo[3,4-b]pyridines Synthesis of pyrimidines Synthesis of dihydropyrimidines Synthesis of dihydropyrimidinones Synthesis of triazolopyrimidines Synthesis of pyridopyrimidines Synthesis of pyrimidopyrimidinediones Synthesis of chromenothiazolopyrimidinones Synthesis of quinoline derivatives Synthesis of quinazolines Synthesis of acridines Synthesis of naphthyridines Synthesis of pyran derivatives Synthesis of 4H-chromenes Synthesis of xanthenes and tetraketones Synthesis of spirooxindoles Synthesis of seven-membered heterocycles Conclusion References One-pot strategy: A highly economical tool in organic synthesis and medicinal chemistry Introduction One-pot synthesis in carbohydrate chemistry One-pot glycosylation strategy in synthesis of medicinally privileged glycosides One-pot synthesis of iminosugar One-pot synthesis of bioactive heterocycles Nitrogen-based bioactive heterocycles Regioselective ring opening/ring expansion of chiral aziridine N, O, and S-based bioactive heterocycles Regioselective oxirane ring opening/expansion Regioselective ring opening/expansion of oxetanes Synthesis of morpholine/piperazine/thiazine Synthesis of functionalized isoxazoles Synthesis of polycyclic azaheterocycles Synthesis of pyrone derivatives Cyclopropane ring expansion Synthesis of aza-heterocycles in one-pot ring opening Synthesis of oxacyclic heterocycles in one-pot Conclusions Acknowledgments References Organocatalytic cycloaddition reaction: A gateway for molecular complexity Introduction [4+2] Cycloaddition reaction [4+2] Cycloaddition via iminium ion activation [4+2] Cycloaddition via enamine activation Ox-indoles in the synthesis of spirocyclic indoles Conclusions Acknowledgments References Diverse synthesis of medicinally active steroids Background on steroid Isolation of steroids molecules Bachmann´s synthesis of equilenin Woodward´s synthesis of cholesterol Synthesis of estrone Synthesis of cortisone Structural classifications, use, and importance Insect steroids or ecdysteroids Vertebrate steroids Classification based on medicinal properties Corticosteroids Plant steroids Different classical synthetic methods Conclusion Acknowledgments References Further reading Reactions in water: Synthesis of biologically active compounds Introduction Properties of water as solvent in synthesis Synthesis of biologically active compounds in water Advantage of using water as a solvent [39, 40] Limitations of using water as a solvent [41, 42] Conclusion Acknowledgment References Solvent-less reactions: Green and sustainable approaches in medicinal chemistry Introduction Principles of green chemistry Green chemistry approaches MW technology Ultrasonication Photocatalysis (ultraviolet, visible, and IR irradiation) Grinding technique Milling technique Experimental conditions for solvent-free reaction Advantages of solvent-free reaction Limitations Conclusion Acknowledgment References Versatile thiosugars in medicinal chemistry Introduction Thiosugars with sulfur as a ring heteroatom: Synthesis and medicinal activity Thiosugars with sulfur outside the ring: Synthesis and medicinal activity Naturally occurring thiosugars: Medicinal activity Conclusions Acknowledgments References Implementing green chemistry for synthesis of cholesterol-lowering statin drugs Introduction Green chemistry in drug synthesis Cholesterol-lowering drugs Statins Lovastatin and simvastatin Background Common production methods Lovastatin Simvastatin Adoption of green technology Green process for simvastatin Green process for lovastatin Adoption of green chemistry for other statins Green process for atorvastatin Green process for rosuvastatin Partial green process for pravastatin Green chemistry in statin analysis Future direction of green chemistry for statins Summary Acknowledgment References Sustainable release of nanodrugs: A new biosafe approach Introduction Problems of conventional drug delivery Why sustainable drug delivery is important? Why nanomaterials are promising as nanodrug? Different nanoparticles as nanodrug and advantages Liposomal nanocarriers Polymer-based NPs in drug delivery Albumin NPs in drug delivery Magnetic nanoparticles in drug delivery Silicon dioxide in drug delivery Zinc oxide in drug delivery Selenium in drug delivery Dendrimers in drug delivery Carbon nanotube in drug delivery Graphene oxide in drug delivery Stimuli-responsive drug delivery by nanoparticles: A new dimension in drug delivery pH-induced drug release Temperature-induced drug delivery Ultrasound-triggered drug delivery Conclusion References Further reading Stimuli-responsive sugar-derived hydrogels: A modern approach in cancer biology Introduction Basic concepts of hydrogels Classifications of hydrogels Chemically cross-linked hydrogels Small-molecule cross-linking Photo-cross-linking Polymer-polymer cross-linking or hybrid polymer networks Interpenetrating networks Enzymatic cross-linking Physically cross-linked (reversible hydrogels) Cross-linking via hydrophobic interaction Cross-linking via ionic complexes Cross-linking via polyelectrolyte complexes Benefits of sugar-derived hydrogel for biological applications Characteristic of stimuli-responsive sugar-derived hydrogels Temperature-responsive hydrogels pH-Responsive hydrogels Light-responsive hydrogels Electric current responsive hydrogels Sound responsive hydrogels Redox-responsive hydrogels Solvent-responsive hydrogels Glucose-responsive hydrogels Hydrogels as in vitro cell culture models Biomimetic hydrogels in the study of MCS Hydrogels as engineered tissue microenvironment Role of hydrogels as drug delivery systems in cancer cells Recent advancements in anticancer drug delivery Conclusion and future perspectives References Further reading Green synthesis and biological evaluation of anticancer drugs Introduction Types of cancer Major features of cancer Signs and symptoms Etiology of cancer Treatment of cancer Chemistry, MOA, and uses anticancer drugs Adverse effects and toxicities of anticancer drugs Synthesis of commonly used anticancer drugs [22] Conventional synthesis of anticancer drugs Green synthesis for development of new anticancer agents Quinoline derivatives as anticancer agents Coumarin derivatives as anticancer agents Synthesis of Imatinib as anticancer agents Synthesis of thiadiazole derivatives as anticancer agent Benzimidazole derivatives as anticancer agents Pyrrole derivatives as anticancer agents Ferulic acid amide derivatives as anticancer agents Pyridine derivatives as anticancer agents Thiazoles as anticancer agents Quinazoline as anticancer agents Pyrazole as anticancer agents Indole derivatives as anticancer agents Pinostrobin as anticancer agent Pyrimidine derivatives as anticancer agents Miscellaneous Conclusion Acknowledgment References Green chemistry and synthetic approaches in the development of antidepressant and antipsychotic agents Introduction Selective serotonin reuptake inhibitors Serotonin-norepinephrine reuptake inhibitors Monoamine oxidase inhibitors Tricyclic antidepressant Norepinephrine-dopamine reuptake inhibitor Conclusion Acknowledgments References Natural spices in medicinal chemistry: Properties and benefits Introduction General features of spices General and chemical features of spices Phytochemical composition Pharmacological activities of ajwain Antimicrobial activity Antiinflammatory activity Antifilarial activity Antilithiasis and diuretic activities Antitussive effects Anthelmintic activity Antihypertensive, antispasmodic, and broncho-dilating activities Antiplatelet-aggregatory Hepatoprotective activity Ameliorative effect Antiflatulant Detoxification of aflatoxins Hypolipidemic action in vivo Nematicidal activity Pharmacological activities of cumin Antimicrobial activity Antioxidant activity Anticarcinogenic/antimutagenic Antidiabetic activity Immunomodulatory activity Antiosteoporotic/estrogenic activity Central nervous system Bioavailability enhancer Pharmacological activities of fennel Antibacterial activity Antifungal activity Antioxidant activity Antiinflammatory activity Antianxiety activity Gastro-protective activity Estrogenic activity Antidiabetic activity Anticancer activity Conclusions Acknowledgments References Further reading Medicinal plants and their compounds with anticancer properties Introduction: Background of medicinal plants Value of medicinal plants Medicinal plants with anticancer properties Solanum nigrum Cynodon dactylon Tinospora cordifolia Momordica dioica Barleria grandiflora Moringa oleifera Cucurbita maxima Terminalia chebula Plant-derived anticancer agents in clinical use Plant-derived anticancer drugs Apoptosis Enzyme inhibitor Conclusions Acknowledgments References Further reading Microwave-assisted synthesis of antitubercular agents: A novel approach Introduction Tuberculosis Microwave chemistry Importance of MW in the synthesis of new anti-TB entities Pyrimidine derivatives as antitubercular agents Thiadiazole derivatives as antitubercular agents Benzodiazepines derivatives as antitubercular agents SAR study of 1,4-benzodiazepines derivatives Hydantoins as antitubercular agents Chalcones as antitubercular agents Quinoline derivatives as antitubercular agents Triazines as antitubercular agents Phenothiazine analogs as antitubercular agents Benzocoumarin-benzothiazepine hybrids as antitubercular agents 1,3,4-Oxadiazoles as antitubercular agents Benzothiazoles as antitubercular agents Indole analogs as antitubercular agents Piperazines as antitubercular agents Pyrazolines as antitubercular agents Benzimidazoles as antitubercular agents Structure-activity relationship (SAR) study Pyridine derivatives as antitubercular agents Thiazolidine derivatives as antitubercular agents 1,3-Oxazole derivatives as antitubercular agents Pyrazinamide-Mannich bases as antitubercular agents 1,2,3-Triazoles as antitubercular agents Future perspective Conclusion Acknowledgments References Microwave-induced synthesis of steroids and their chemical manipulations Microwave background Microwave in steroid synthesis Microwave in the synthesis of compounds based on the properties (cholesterol, hormone, bile acid, vitamin, steroids ... Comparison of microwave vs classical method Conclusion Acknowledgments References Microwave-induced synthesis as a part of green chemistry approach for novel antiinflammatory agents Inflammation Acute inflammation Chronic inflammation Mediators of inflammation Importance of antiinflammatory drugs Nitric oxide (NO)-donating NSAIDs (NO-NSAIDs) Selective COX-2 inhibitors Dual COX/LOX inhibitors Ipoprotein-PLA2 inhibitors Microsomal prostaglandin E2 synthase inhibitors TNF-α inhibitors Introduction to microwave technique Microwaves Mechanism of microwave heating Benefits of microwave-assisted synthesis Microwave synthesis apparatus Single-mode microwave apparatus Multimode microwave apparatus Applications of microwave-assisted synthesis Microwave-assisted synthesis of novel antiinflammatory agents Acknowledgments References Dipole moment in medicinal research: Green and sustainable approach Background on dipole moment 2-Pyrrolidone Cholestanone Purines, pyrimidines, and azines Thiophene and carboxamides Dipole moment and anticancer activity Organometallic bismuth (III) compounds Topovale MDMA Efavirenz (EFZ) Adriamycin and daunomycin Methotrexate, temozolomide, carmustine, tamoxifen, and hydroxifen Ruthenium azopyridine complex Glutamine Lantadenes Xanthone Fullerene C60 and benzopyrene Coumarins Dipole moment and antifungal activity Thiosemicarbazide Pyrazolopyridines Oxadiazoles Beta-pinene (β-pinene) Indol-4-one Aminobenzenesulfonamide Schiff bases Chalcones and chromanes Dipole moment and antibacterial activity Copper (II) complexes with quinolones and nitrogen-donor heterocycles Thiourea derivatives Indolylpyrimidines Terpenes and phenylporpanes Quinazolinone Azole-derived compounds Polyphenols Dipole moment and various other medical disorders (antimicrobial, antimalarial, and antileishmanial) Hydrazide analogs Phenothiazine (PTZ) Thiazolidine Cinchona alkaloids Tetraoxanes Chalcones Cimetidine analogs Conclusions Acknowledgments References Computational methods and tools for sustainable and green approaches in drug discovery Introduction QSAR, 3D QSAR, and ligand-based drug design Why there is a need for QSAR? Ligand-based virtual screening Structure-based drug design and virtual screening strategy Binding site detection, protein, and ligand refinement Direct docking Structure-based pharmacophore screening Analysis of the hits Similarity searching Homology modeling Drugability References Index
