Gonococci and Meningococci: Epidemiology, Genetics, Immunochemistry and Pathogenesis

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Epidemiology and vaccination....Pages 3-4
Class 1OMP subtyping of meningococci....Pages 5-10
The reduction of nitrite by Neisseria meningitidis . Relation to serogroup and serotype....Pages 11-14
Monoclonal antibody analysis of meningococcal disease strains isolated in Canada....Pages 15-19
Outcome of Neisseria meningitidis serogroup C infection in a small outbreak of disease....Pages 21-25
Epidemiology of meningococcal (sub)types in the Netherlands....Pages 27-32
Tetravalent meningococcal polysaccharide vaccine. Relationship of dose to immunogenicity and reactogenicity in young adults....Pages 33-37
Plasma LPS and clinical pictures in meningococcal disease....Pages 39-43
Serological classification of Neisseria gonorrhoeae . Clinical and epidemiological applications....Pages 45-50
Epidemiology of meningococcal disease in Switzerland, 1980–1986:Using monoclonal antibodies to classify disease-related isolates....Pages 51-55
Intercontinental spread of Neisseria Meningitidis clones of the ET-5 Complex....Pages 57-62
Serological Classification of Neisseria Gonorrhoeae . Serovars Associated with Homosexually Acquired Infection....Pages 63-72
A clonal analysis of Neisseria meningitidis serogroup A....Pages 73-80
Epidemiology of Infections with Pathogenic Neisseriae in Sweden....Pages 81-90
Immunoglobulin isotype deficiency and response to meningococcal polysaccharides....Pages 91-96
Appearance of new strains associated with group B meningococcal disease and their use for rapid vaccine development....Pages 97-104
Monitoring of systemic meningococcal isolates from Norway....Pages 105-108
Immune response to meningococcal serogroup B polysaccharide and serotype 2a outer membrane complex vaccines....Pages 109-113
DNA hybridisation between the gonococcal cryptic plasmid and plasmids isolated from Neisseria meningitidis and Neisseria lactamica ....Pages 115-118
Types and subtypes of group B meningococci isolated in Finland from 1976 through April 1986....Pages 119-124
Front Matter....Pages 1-1
Distribution and frequency of strains of Neisseria gonorrhoeae with plasmid-mediated, high-level resistance to tetracycline (TRNG) in the United States....Pages 125-129
Distribution and temporal changes in Neisseria gonorrhoeae auxotype/serovar classes in Seattle, Washington....Pages 131-135
High-level tetracycline resistance associated with tetM in Neisseria meningitidis and other Neisseriaceae ....Pages 137-141
Characterization of Neisseria gonorrhoeae isolates from prostitutes with single and multiple infections....Pages 143-146
Antigenicity of meningococcal group B oligo- and polysaccharides of defined chain length....Pages 147-152
Acquisition of the streptococcal tetM determinant by Neisseria gonorrhoeae ....Pages 153-158
Comparison of meningococcal outer membrane protein vaccines solubilized with detergent or C polysaccharide....Pages 159-165
Evaluation of Sampling Methods for Surveillance of Neisseria Gonorrhoeae Strain Populations....Pages 167-173
Association of meningococcal serogroups and types with the course of disease, the Netherlands 1959–1983 (n = 1221)....Pages 175-180
Immunogenic activity of gonococcal PI in mice delivered in liposomes, iscoms and detergent complexes....Pages 181-186
DNA sandwich-hybridisation assay of the cryptic plasmid from Neisseria gonorrhoeae ....Pages 187-191
The prevalence and characteristics of arginine, hypoxanthine and uracil requiring strains of Neisseria gonorrhoeae isolated at two London hospitals....Pages 193-197
An epidemiological and serological study on duration of protection after meningococcal Group A polysaccharide (APS) vaccination....Pages 199-207
Human bactericidal antibody response to meningococcal outer membrane protein vaccines....Pages 209-217
Front Matter....Pages 219-219
Neisseria genetics....Pages 221-222
Linkage of genetic markers in AHU strains of Neisseria gonorrhoeae ....Pages 223-230
Specificity in DNA uptake by gonococci....Pages 231-234
Genetic and biochemical analyses of protein II....Pages 235-238
In-vivo loss of gonococcal ß-lactamase plasmid....Pages 239-244
Pilin independent binding of Neisseria gonorrhoeae to immobilized glycolipids....Pages 245-250
Front Matter....Pages 219-219
DNA enzymes of Neisseria gonorrhoeae ....Pages 251-256
Molecular cloning and characterization of a gonococcal surface antigen common to pathogenic Neisseria spp.....Pages 257-262
The effect of outer membrane proteins and lipopolysaccharide on the ability of Neisseria gonorrhoeae to transfer plasmids by conjugation to Neisseria cinerea ....Pages 263-268
Molecular principles of antigenic variation in Neisseria gonorrhoeae....Pages 269-272
The presence of DNA sequences Related to a 4.2Kb cryptic plasmid in the chromosomes of plasmid-free strains of Neisseria gonorrhoeae ....Pages 273-281
The control mechanism of opacity protein expression in the pathogenic Neisseriae ....Pages 283-288
Sequence analysis of variant pilin genes from Neisseria gonorrhoeae P9 and immunological properties of pilin polypeptides encoded by cloned genes in Escherichia coli ....Pages 289-296
Three dimensional structure of bacterial pili....Pages 297-303
Inter-strain homology of pilin gene sequences in Neisseria meningitidis isolates that express markedly different antigenic pilus types....Pages 305-310
Cloning of a gene for methionine biosynthesis from Neisseria gonorrhoeae . Identification by interspecific complementation of Escherichia coli mutants....Pages 311-315
Homology between the indigenous plasmids and chromosome of Neisseria gonorrhoeae ....Pages 317-322
Role of restriction and modification on genetic exchange in Neisseria gonorrhoeae ....Pages 323-327
Determination of the endonuclease and methylase content of Neisseria gonorrhoeae strain P9 and the cloning therefrom of two functional methylase genes....Pages 329-334
Gene conversion accounts for pilin structural changes and for reversible piliation “phase” changes in gonococci....Pages 335-340
Front Matter....Pages 341-341
Outer membrane proteins and IgA protease....Pages 343-344
 Neisseria meningitidis —Outer membrane proteins released into the growth medium....Pages 345-348
The isolation and partial characterization of naturally-evolved outer membrane blebs of Neisseria gonorrhoeae ....Pages 349-356
Monoclonal antibody directed against a surface-exposed protein antigen common in gonococcal strains....Pages 357-362
Gonococcal protein III. Purification and chemical characterization of the protein, and the DNA sequence of the structural gene....Pages 363-367
Immunobiology of gonococcal outer membrane protein I....Pages 369-371
Front Matter....Pages 341-341
Structural an immmunological characterization of cell wall antigens in strains FA638 and CS7 of Neisseria gonorrhoeae ....Pages 373-381
Characterization of protein I from serum sensitive and serum resistant transformants of Neisseria gonorrhoeae ....Pages 383-392
High resolution two-dimensional analysis of the proteins of Neisseria gonorrhoeae colony Type 1 and 4, heat shocked and non- heat shocked....Pages 393-399
Description of a common, stable, and surface exposed neisserial antigen of 70 kilodaltons....Pages 401-404
Characterization of the major iron-regulated protein of Neisseria gonorrhoeae and Neissereria meningitidis ....Pages 405-409
Purification of native pili and outer membrane vesicles from Neisseria gonorrhoeae ....Pages 411-417
Restriction site polymorphism in genes encoding type 2 but not type 1 gonococcal IgAl proteases....Pages 419-426
 Neisseria gonorrhoeae IgA protease. Secretion and implications for pathogenesis....Pages 427-432
Examination of a surface exposed epitope on the protein IA molecule of Neisseria gonorrhoeae ....Pages 433-439
Development of a tissue culture model for gonococcal invasion....Pages 441-447
Antigenic and immunogenic properties of cyanogen bromide peptides from a serotype 5 gonococcal outer membrane protein I....Pages 449-455
Characterization of antibodies raised to Protein I (PI) of Neisseria Gonorrhoeae by injection with PI — liposome constructs....Pages 457-463
Front Matter....Pages 465-465
Lipopolysaccharide, H8 antigen and peptidoglycan in Neisseriae ....Pages 467-468
Human immune response to Neisseria gonorrhoeae lipooligosaccharides....Pages 469-475
Phenotypic variation of the antigen expression of the lipooligosaccharide of Neisseria gonorrhoeae ....Pages 477-483
Immonochemical characterization of surface antigen common to the Pathogenic Neisseria species....Pages 485-492
Serum immune response to common pathogenic Neisseria antigen H8 in patients with uncomplicated gonococcal infection and pelvic inflammatory disease....Pages 493-497
Peptidoglycan structure in Neisseria gonorrhoeae grown in continuous culture....Pages 499-501
A liposome model of bacteriolysis supports the role of lipooligosaccharide (LOS) and anti-LOS antibody in the complement-dependent killing of N. gonorrhoeae ....Pages 503-510
Antibodies against Neisseria gonorrhoeae lipooligosaccharide antigens stimulate neutrophil chemotaxis....Pages 511-518
Front Matter....Pages 465-465
Three distinct gonococcal genes related to H8 antigens....Pages 519-522
Antigenic specificity of natural bactericidal activity for serogroup B and C strains of Neisseria meningitidis in human sera....Pages 523-527
The immunochemistry of neisserial LOS....Pages 529-535
Spontaneous variation of lipooligosaccharide components and epitopes in a strain of Neisseria gonorrhoeae ....Pages 537-541
Analyses of the immunoaccessibility of H8 antigen and the functionality of H8 specific monoclonal antibody 10....Pages 543-552
Structure and immunochemistry of meningococcal lipopolysaccharides....Pages 553-556
Electromorphologic characterization of the lipooligosaccharides of group A Neisseria meningitidis ....Pages 557-562
Monoclonal antibody identification of shared lipooligosaccharide epitopes of Neisseria meningitidis and Neisseria lactamica ....Pages 563-567
Human immune response to monoclonal antibody — defined epitopes of Neisseria gonorrhoeae lipooligosaccharides....Pages 569-574
Characterization of Neisseria gonorrhoeae lipopolysaccharide biosynthesis genes cloned in Escherichia coli K12....Pages 575-580
Promotion of sleep by gonococcal peptidoglycan fragments. Structural requirements for the somnogenic activity....Pages 581-590
The gonococcal C Antigen partitions into phenol and is immunogenic in mice....Pages 591-597
Alteration of serum sensitivity in Neisseria gonorrhoeae strain DOV by transformation....Pages 599-604
Isolation and characterization of the gonococcal H8 antigen....Pages 605-611
The H8 antigen of pathogenic Neisseriae ....Pages 613-616
Front Matter....Pages 617-617
Pathogenesis....Pages 619-620
Endotoxin liberation from Neisseria meningitidis isolated from carriers and clinical cases....Pages 621-625
Chemical nature of binding properties of an opacity-associated Protein II of the gonococcus....Pages 627-632
Non-secretion of blood group antigens. A genetic factor predisposing to infection by Neisseria meningitidis ....Pages 633-636
Exposure to myeloid and other mammalian cells increases Neisseria gonorrhoeae O 2 utilization. Implications for pathogenesis....Pages 637-643
Front Matter....Pages 617-617
Anaerobic growth of Neisseria gonorrhoeae induces and represses synthesis of outer membrane proteins....Pages 645-651
Anaerobically expressed outer membrane proteins of Neisseria gonorrhoeae are recognized by antibodies present in the sera of PID patients....Pages 653-658
Metabolic responses of Neisseria gonorrhoeae to human serum and myeloid cells. Adaptation to host defenses?....Pages 659-664
Use of the quinone antibiotic streptonigrin to explore the iron and oxygen metabolism of Neisseria gonorrhoeae . Mechanisms of antibiotic action and resistance....Pages 665-672
Decreased toxicity of paraquat for gonococci due to glucose concentration....Pages 673-678
Characterization of cells responsible for ADCC and natural cytotoxicity against gonococci....Pages 679-684
Antibodies to outer membrane protein — macromolecular complex (OMP-MC) are bactericidal for serum-resistant gonococci....Pages 685-691
The contribution of the alternative and classical complement pathways to gonococcal killing and C3 fixation....Pages 693-697
The role of P.II outer membrane proteins in gonococcus — host cell interactions....Pages 699-702
Invasion of tissue culture cells by Neisseria gonorrhoeae colony phenotype variants....Pages 703-709
Cell surface hydrophobicity of Neisseria gonorrhoeae colony phenotype variants....Pages 711-715
Strain-specific direct binding of properdin accounts for variable lysis of Neisseria gonorrhoeae ....Pages 717-722
The opsonisation and phagocytosis of group B by polymorphonuclear leucocytes. A comparison of sulphonamide sensitive and resistant strains....Pages 723-726
Influence of iron-limited and excess continuous culture on the virulence properties of Neisseria gonorrhoeae ....Pages 727-729
IgG subclasses reactive with Neisseria gonorrhoeae antigens in the immune response to infection....Pages 731-736
Antigenic specificity and biological activity of a monoclonal antibody that is broadly cross reactive with gonococcal protein IIs....Pages 737-743
Interaction of Neisseria gonorrhoeae and protein IA with HEp-2 cells....Pages 745-751
Enteric immunization reveals a T cell network for IgA responses and suggests that humans possess a common mucosal immune system....Pages 753-759
Serum and vaginal fluid antibodies against the major iron-regulated protein in women with gonococcal pelvic inflammatory disease or uncomplicated infection....Pages 761-765
The ability of Neisseriae to use lactoferrin as an iron source depends on the presence of a lactoferrin binding site....Pages 767-774
Front Matter....Pages 617-617
Gonococci in vivo and in vitro. Further studies on the host and bacterial determinants of gonococcal resistance to killing by human serum, and by phagocytes....Pages 775-779
Differential expression of “Fe-repressible” and “growth-rate-sensitive” proteins in Neisseria meningitidis and Neisseria gonorrhoeae ....Pages 781-788
Mechanisms of stable serum resistance of Neisseria gonorrhoeae ....Pages 789-798
Iron and meningococcal disease. S-ferritin, S-iron and S-total iron binding capacity in meningococcal disease patients and patient controls....Pages 799-805
Adherence of Neisseria meningitidis to human buccal and pharyngeal epithelial cells. Relationship to bacteriocin-like substances....Pages 807-814
Infant rat model for meningococcal group B infection....Pages 815-820
Interaction of lysosomal cathepsin G with N. gonorrhoeae ....Pages 821-825
Cytopathic effects of the pathogenic Neisseria . Studies using human fallopian tube organ cultures and human nasopharyngeal organ cultures....Pages 827-836
Polyphosphate-mediated release of iron from transferrin. A possible mechanism for acquisition of iron from transferrin by Neisseria gonorrhoeae ....Pages 837-842