Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH). The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease

Content: 
Dedication,Front Matter,Copyright,Biography,Acknowledgments,IntroductionEntitled to full textSection I: The Role of Moonlighting GAPDH in Normal Cell FunctionChapter 1 - The Role of Moonlighting GAPDH in Cell Proliferation: The Dynamic Nature of GAPDH Expression and Subcellular Localization, Pages 3-20
Chapter 2 - Moonlighting GAPDH and the Transcriptional Regulation of Gene Expression: Multiprotein Complex Formation and Mechanisms of Nuclear Translocation, Pages 21-33
Chapter 3 - The Diversity of Moonlighting GAPDH Function in Posttranscriptional RNA Regulation: mRNA Stability, tRNA Processing, and Viral Pathogenesis, Pages 35-56
Chapter 4 - The Role of Moonlighting GAPDH in Membrane Structure and Function: Membrane Fusion and Iron Metabolism, Pages 57-76
Chapter 5 - The Role of Moonlighting GAPDH in Intracellular Membrane Trafficking: Tubulin Regulation and Modulation of Cytoskeletal Structure, Pages 77-95
Chapter 6 - Moonlighting GAPDH and the Maintenance of DNA Integrity: Preservation of Genetic Information and Cancer Facilitation, Pages 97-111
Chapter 7 - Moonlighting GAPDH in Neuronal Structure and Function: Regulation of Ion Channels and Signal Transduction, Pages 113-128
Chapter 8 - The Significance of Nitric Oxide–Modified GAPDH: Regulation of Apoptosis, Cell Signaling, and Heme Metabolism, Pages 131-154
Chapter 9 - GAPDH and Hypoxia: Mechanisms of Cell Survival During Oxygen Deprivation, Pages 155-165
Chapter 10 - Moonlighting GAPDH and Ischemia: Cellular and Molecular Effects of Oxygen Deprivation and Reperfusion, Pages 167-178
Chapter 11 - GAPDH and Tumorigenesis: Molecular Mechanisms of Cancer Development and Survival, Pages 181-197
Chapter 12 - Moonlighting GAPDH and Age-Related Neurodegenerative Disease: Diversity of Protein Interactions and Complexity of Function, Pages 199-219
Chapter 13 - Functional Diversity of GAPDH in Infection and Immunity: The Complexity of “Simple” Organisms, Pages 221-239
Chapter 14 - Moonlighting GAPDH and Diabetes: Pleiotropic Effects of Perturbations in GAPDH Structure and Function, Pages 241-257
Section IV - The Pharmacology of Moonlighting GAPDH, Pages 259-277
Section V - The Unique Role of Sperm-Specific GAPDH, Pages 279-295
Section VI - Discussion, Pages 297-298
Index, Pages 299-306