Germinal Centers in Immune Responses: Proceedings of a Symposium held, at the University of Bern, Switzerland, June 22–24, 1966

Front Matter....Pages I-XV
Comparison of Existing Theories on the Function of Germinal Centers....Pages 1-3
The Phylogenetic Development of Immune Responses and the Germinal Center System....Pages 4-27
Ontogenetic Development of the Germinal Centers and Their Function — Relationship to the Bursa of Fabricius....Pages 28-33
Germinal Centers in the Tonsilla Caecalis — Relationship to the Thymus and the Bursa of Fabricius....Pages 34-39
The Formation of Germinal Centers in the Medulla of Lymph Nodes....Pages 40-48
Electron Microscopic Studies of Germinal Centers in Man....Pages 49-59
Ultrastructural Modifications of the Lymph Nodes after Homologous Skin Grafting in the Mouse....Pages 60-70
Observations on the Ultrastructure of Lymphatic Tissue Germinal Centers....Pages 71-79
Localization of γ-Globulin and Labeled Antigen in Germinal Centers in Relation to the Immune Response....Pages 80-85
Lymphatic Tissue Germinal Center Localization of 125 I-labeled Heterologous and Isologous Macroglobulins....Pages 86-94
Basic Peptides Produced in Polymorphonuclear Leucocytes and Thymus-Evidence of Complexes with Serum Globulins....Pages 95-101
The Morphologic Demonstration of Antibody Formation in Follicles of Lymphoid Tissue....Pages 102-111
The Immunoglobulins Present in the Germinal Centers....Pages 112-119
Synthesis of Human Immunoglobulins in Germinal Centers....Pages 120-125
Lymph Node Plasma Cell Production in Secondary Immune Response....Pages 126-130
Germinal Center Formation and Antigen Localization in Malpighian Bodies of the Chicken Spleen....Pages 131-144
Radioautographic Studies of Reticular and Lymphoid Cells in Germinal Centers of Lymph Nodes....Pages 145-151
Thymidine- 3 H in Developing Germinal Centers....Pages 152-156
Mitotic Activity of Two Chromosomally Marked Populations of Cells in an Immune Response....Pages 157-160
Lymphoid Cell Lines in the Thoracic Duct of the Calf with Different Generation Times....Pages 161-167
The Integrity of the Germinal Center: An Investigation of the Differential Localization of Labeled Cells in Lymphoid Organs....Pages 168-175
Cell Production and Cell Migration in the Tonsil....Pages 176-182
The Fate of Lymphoid Cells from the White Pulp at the Peak of Germinal Center Formation....Pages 183-188
Morphologic and Autoradiographic Studies of Spleen White Pulp Germinal Centers after Antigen Injection....Pages 189-198
Quantitative Studies of Lymphocyte Mobilization and Uptake of Antigen by Lymphocytes During Primary Antibody Response against Protein Antigens....Pages 199-211
Kinetics of Cellular Death in Germinal Centers of Mouse Spleen....Pages 212-217
On the Origin of Tingible Bodies in Germinal Centers....Pages 218-224
The Effects of Immuno Suppressant Drugs Administered During Germinal Center Proliferation on Preparation for a Secondary Antibody Response in Rabbits....Pages 225-233
Comparative Changes in the Mouse Spleen During Immunostimulation or Immuno-suppression....Pages 234-239
Effects of Local Irradiation of the Spleen on the Primary Response in Rats....Pages 240-249
Regeneration Patterns of Lymphoid Follicles in the Rabbit Spleen after Sublethal X-irradiation....Pages 250-258
The Production of Memory Cells by the White Pulp of the Spleen in Rabbits....Pages 259-269
De novo Formation and Rapid Growth of Germinal Centers During Secondary Antibody Responses to Tetanus Toxoid in Mice....Pages 270-276
Germinal Centers, Allograft Sensitivity and Iso-antibody Formation in Skin Allografted Mice....Pages 277-285
Recent Observations on the Origin and Fate of Antigen-Stimulated Cells in the Rat Spleen....Pages 286-296
In vitro Studies of Cell-bound Immunity Induced by Tumor Allografts; Inhibitory Effects of Iso-antibody....Pages 297-305
Immune Response of Lymph Nodes to Skin Allografts: Effects of Proteolytic Enzymes and of an Inhibitor of the Proteolysis....Pages 306-310
Germinal Center Activity in Relation to Delayed Hypersensitivity....Pages 311-318
The Effect of Antigen Dose on the Changes in the Spleen: Tolerance versus Immunity....Pages 319-328
Lymphoid Regeneration Following x-Ray Treatment and the Susceptibility to the Induction of Immunological Tolerance....Pages 329-332
The Cellular Components in the Induction of Antibody by x-Irradiated Animals....Pages 333-339
Germfree Animals....Pages 340-342
Germinal Centers in Germfree Animals....Pages 343-348
Histological and Autoradiographic Studies on the Follicles of Neonatally Thymectomized Mice....Pages 349-355
Development of Lymphatic Tissues in Early Thymectomized “Swiss Albino” Mice....Pages 356-360
The Definition of a Germinal Center Area as Distinct from the Thymus-Dependent Area in the Lymphoid Tissue of the Mouse....Pages 361-370
Lymphoid Restoration of Neonatally Thymectomized Mice with Thymus Epithelial Reticular Cell Remnants....Pages 371-378
Germinal Centers and Plasma Cells in the Thymus of the Chicken....Pages 379-385
Immunological Deficiency Diseases of Man — Relationships to Disturbances of Germinal Center Formation....Pages 386-407
Germinal Centers in Autoimmune Disease....Pages 408-414
Germinal Centers in Autoimmune Disease....Pages 415-421
Tumor Resistance and Tumor Enhancement with SV 40 Virus-induced Tumors....Pages 422-427
Human Germinal Centers Lymph Nodes Responses to Leukemogenic Viruses in vitro....Pages 428-431
Germinal Centers in Malignant Trophoblastic Disease....Pages 432-437
Cytochemical Investigation on Normal and Pathological Lymph Nodes....Pages 438-442
Lymphomagenesis in Relation to Germinal Centers and to the Bursa of Fabridus....Pages 443-446
The Giant Follicular Lymphoma (Brill-Symmers’ Disease)....Pages 447-459
Summary and Closing Remarks....Pages 460-466
Back Matter....Pages 467-499