Germ Cell Tumours III. Proceedings of the Third Germ Cell Tumour Conference Held in Leeds, UK, on 8th–10th September 1993

Content: 
ADVANCES IN THE BIOSCIENCES, Page ii
Front Matter, Page iii
Copyright, Page iv
III Germ Cell Tumour Conference, Page v
Dedication, Page vii
Preface, Pages ix-x, W.G. Jones, P. Harnden, I. Appleyard
Acknowledgements, Page xi
Embryological Mechanisms of Maldescent and Tumourigenesis, Pages 1-6, John M. Hutson, Marilyn L. Baker, Masaru Terada, Baiyun Zhou, Georgia Paxton
The Epidemiological Association between Undescended Testis, Inguinal Hernia and Testicular Cancer: Results from the U.K. National Case-Control Study of Testicular Cancer, Pages 7-11, D. Forman, C. Chilvers, G. Davey, C. Coupland
The Epidemiology of Cryptorchidism: Results from the John Radcliffe Hospital Cryptorchidism Study, Pages 13-19, Clair Chilvers, Pat Ansell, Diana Bull, Carol Coupland, Malcolm Pike
Maldescent and Cryptorchidism: A Rational Approach to Management, Pages 21-24, D.F.M. Thomas
Recent Progress in Research on CIS in Adults. Biological Aspects and Screening, Pages 25-36, Aleksander Giwercman, Niels E. Skakkebæk
Simultaneous Bilateral Testicular Tumours, Page 37, D.W.W. Newling
Are Paediatric Germ Cell Tumours Germ Cell Tumours?, Pages 39-45, Isabell A. Sesterhenn, Charles J. Davis Jr, F.K. Mostofi
Pathology and Cytogonetics of Germ Cell Tumours in Children, Pages 47-56, Faro Raafat
UKCCSG Studies of Paediatric Germ Cell Tumours, Pages 57-58, Anthony Oakhill
Changing Pattern of Incidence and Survival in Children with Germ Cell Tumours (GCTs), Pages 59-64, Jillian R. Mann, C.A. Stiller
Testicular Non-Seminomatous Germ Cell Tumour (TGMnS) French Society of Pediatric Oncology Experience (SFOP), 1985–1989, Page 65, M.C. Baranzelli, C. Patte, E. Quintana, H. Rubie, A. Thyss, C. Behar, P. Boutard, J.P. Vannier, E. Le Gall, C. Schmitt, O. Lejars, F. Dusol, E. Sariban, M.Th. Boguais, F. Flamant
Chemotherapy Associated Toxicity in Patients with Malignant Non Testicular Germ Cell Tumours (MNGCTs). Comparison of MAKEI 83/86 and MAKEI 89, Pages 67-68, G. Calaminus, C. Teske, U. Göbel
Germ Cell Tumours in Children: A Report of 84 Cases, Pages 69-70, M. Lo Curto, G. Provenzano, A. Zingone, S. Bagnulo, G. Bernini, G. Cecchetto, B. De Bernardi, E. De Grazia, C. De Laurentis, S. Di Benedetto, M. Di Pace, M.T. Di Tullio, A.M. Fagnani, L. Felici, M. Lo Cascio, S. Lo Piccolo, P. Macchia, F. Massolo, N. Santoro, F. Siracusa,  et al.
Paediatric Germ Cell Tumours in the West Midlands Health Authority Region (WMHAR): Increasing Incidence and Pattern of Geographical Distribution, Page 71, S.E. Parkes, K.R. Muir, S. Lawson, A.K. Thomas, A.H. Cameron, J.R. Mann
Gonadotrophin and Sex Hormone Levels in Testis Cancer Patients with and without Carcinoma In Situ of the Contralateral Testis, Pages 73-76, P.A. Cook, S.D. Fosså, A. Horwich, M.C. Parkinson, J.T. Roberts, S.P. Stenning, S.J. Harland
Contralateral Biopsies in Patients with Testicular Germ Cell Tumour — The German Experience, Pages 77-81, K.-P. Dieckmann, V. Loy
Seminal Fluid Analysis and Carcinoma-In-Situ of the Testis, Pages 83-84, E.T. Brackenbury, G.C.W.H. Howard, T.B. Hargreave, M.A. McIntyre
Abdominal CT Scans in Patients with Retroperitoneal Germ Cell Tumours with or without Carcinoma In Situ, Page 85, G. Daugaard, K. Damgaard, N.E. Skakkebæk, M. Rørth
The Value of Testicular Biopsy as a Screening Procedure for Future Malignant Germ Cell Tumours in Infertile Men, Page 87, J.P. Pryor, C. Bettocchi, M.C. Parkinson, J. Deacon
Interphase Cytogenetics of Testicular Germ Cell Tumours: Clonal Origin of Seminoma and Nonseminoma Components in Combined Tumours, Pages 89-94, J.W. Oosterhuis, A.J.M. Gillis, B. de Jong, L.H.J. Looijenga
Growth of Human Seminoma Cells on STO Feeder Depends on Phenotype, Presence of Fetal Calf Serum and Added Growth Factors, Pages 95-106, Robert A. Olie, Leendert H.J. Looijenga, Marjolein C. Dekker, Frank H. de Jong, Dick G. de Rooij, J. Wolter Oosterhuis
Molecular Genetics in Germ Cell Tumours, Pages 107-111, R.S.K. Chaganti, V.V.V.S. Murty, Jane Houldsworth, Pulivarthy H. Rao, Eduardo Rodriguez, George J. Bosl
Mediastinal Germ Cell Tumours, Pages 113-117, Craig R. Nichols, Bruce Roth, Patrick J. Loehrer, Scott B. Saxman, Stephen D. Williams, Lawrence H. Einhorn
The Origin of Non-Germ Cell Tumour Elements within Germ Cell Tumours and Midline Tumours of Uncertain Histogenesis, Pages 119-124, Michael L. Meyers, R.S.K. Chaganti, Robert J. Motzer, George J. Bosl
Unusual Neoplasms Detected in Testis Cancer Patients Undergoing Post Chemotherapy Retroperitoneal Lymphadenectomy, Pages 125-134, J.S. Little Jr, R.S. Foster, T. Ulbright, J.P. Donohue
Outcome Analysis for Patients with Persistent Non-Seminomatous Germ Cell Tumour in Post-Chemotherapy Retroperitoneal Lymph Node Dissections, Pages 135-143, John P. Donohue, Edward P. Fox, Stephen D. Williams, Patrick J. Loehrer, Thomas M. Ulbright, Lawrence H. Einhorn, Tess D. Weathers
The Wilms' Tumour 1 Gene in Testicular Cancer Patients, Pages 145-146, A.-L. Børresen, K. Heimdal, R.A. Lothe, S.D. Fosså
Image Analysis Quantitation of p53 Gene Product and Ki-67 in Testicular Germ Cell Tumours — A Quantitative Immunohistochemical Study, Page 147, A. Hittmair, R. Bale, H. Rogatsch, G. Mikuz, H. Feichtinger
Is Apoptosis an Important Mode of Death in Embryonal Carcinoma?, Page 149, R.A. Huddart, J.L. Titley, M. Pera, A. Horwich, C.S. Cooper
Growth Inhibition and Differentiation of a Human Embryonal Carcinoma (EC) Cell Line by Osteogenic Protein-1 (OP-1), Pages 151-152, P.W. Andrews, F. Mavilio, V. Zappavigna, T.K. Sampath
Revised International Histological Classification of Testicular Tumours, Pages 153-158, F.K. Mostofi, I.A. Sesterhenn
New Classification of Germ Cell Tumours, Pages 159-160, K.M. Grigor
Discussion on the Classification of Germ Cell Tumours, Page 161, P. Harnden
Grading Germ Cell Tumours as a Means to Resolve the Last Twenty Five Years Transatlantic Conflict over Testis Tumour Classification, Pages 163-164, R.T.D. Oliver
The Clinical Value of Imaging Germ Cell Tumours with Radiolabelled Antibodies, Pages 165-168, R.H.J. Begent, A.J. Green, D.M. Lane, L. Hope-Stone, D.A. Read, W. Nicholas, P.A. Keep
The Role of Positron Emission Tomography in the Assessment of Germ Cell Tumours, Pages 169-175, R.P. Beaney, W.L. Wong
The Princess Margaret Hospital Experience in the Management of Stage I and II Seminoma — 1981 to 1991, Pages 177-185, M.K. Gospodarowicz, P.R. Warde, T. Panzarella, C.N. Catton, J.F.G. Sturgeon, M. Moore, M.A.S. Jewett
Chemotherapy of Seminoma, Pages 187-191, A. Horwich
Late Relapse in Patients on Surveillance for Stage I Testicular Seminoma, Pages 193-194, P. Warde, M. Gospodarowicz, P. Goodman, J. Sturgeon, M. Jewett, C. Catton, M. Moore, H. Richmond
Surveillance of Stage 1 Non-Seminomatous Testicular Cancer — A Preliminary Report of the EORTC GU-Cooperative Group Surveillance Study, Pages 195-199, A.T. van Oosterom, C. Vendrik, J. Keizer, J.P. Droz, J. Schornagel, J. Croles, T. Splinter, F. Ten Kate, K. Vermeylen, R. Sylvester
Short Course Adjuvant Chemotherapy in High Risk Stage I Non-Seminomatous Germ Cell Tumours of the Testis (NSGCTT): An MRC Study Report, Pages 201-202, M.H. Cullen
One Course Adjuvant Treatment for Stage 1 Germ Cell Tumours, Pages 203-205, R.T.D. Oliver
NSGCT Stage I — Adjuvant Chemotherapy for Patients with Vascular Invasion and Surveillance for Patients without Vascular Invasion: Update of a Prospective Trial after 8 Years, Pages 207-208, J. Pont, W. Albrecht, W. Höltl
Testicular Cancer in Russia, Pages 209-212, S. Tjulandin, F. Gutierrez, A. Khlebnov, I. Olkhovskay, A. Sokolov, E. Aksel, V. Dvoirin, A. Garin
Good Risk Chemotherapy Trials for Patients with Advanced Germ Cell Tumours: The MSKCC Experience, Pages 213-220, Teresa A. Murray, Dean F. Bajorin, Robert J. Motzer, George J. Bosl
Carboplatin-Based Chemotherapy in Good Prognosis Metastatic Non-Seminoma of the Testis (NSGCT): An Interim Report of an MRC/EORTC Randomised Trial, Page 221, A. Horwich, D. Sleijfer
Insurance Status as a Prognostic Factor for Stage and Survival of Testicular Cancer Patients in Illinois, Pages 223-233, Nicholas J. Vogelzang, Amy M. Fremgen, Patrick D. Guinan, Joan S. Chmiel, JoAnne L. Sylvester, Stephen F. Sener, Joseph Imperato
Prognostic Factors in Metastatic Seminoma and Non-Seminomatous Germ Cell Tumours, Page 235, G.M. Mead, S. Stenning
Prognostic Factors in Disseminated Non-Seminomatous Testicular Cancer, Pages 237-238, R. de Wit, G. Stoter, R. Sylvester
Predictors of Residual Mass Histology Following Chemotherapy for Metastatic Nonseminomatous GCT: Univariate and Multivariate Meta-Analysis, Pages 239-240, E.W. Steyerberg, H.J. Keizer, S.D. Fosså, P.F.A. Mulders, G. Stoter, J.E. Messemer, K. Ney, J.P. Donohue, G.C. Toner, D. Bajorin, G.J. Bosl, J.D.F. Habbema
Resection of Small Masses of Residual NSGCT and Subsequent Therapy: Dilemmas in Clinical Decision Making, Page 241, H.J. Keizer, E.W. Steyerberg
Needs, Findings and Outcome of Post-Chemotherapy Surgery of Residual Masses (RM) in Patients with Non-Seminomatous Germ Cell Testis Tumours (NSGCTT) at a Single Institution, Pages 243-244, J.R. Germà, A. Mercedes, A. Rueda, J.M. Tabernero, R. Mesia, J. Farinas, H. Villavicencio, F.J. Sole-Balcells, C. Leon, J.J. Lopez
Treatment of Central Nervous System (CNS) Metastases of Non-Seminomatous Germ Cell Tumours: The Charing Cross Experience, Page 247, S.M. O'Reilly, G.J.S. Rustin, E.S. Newlands
Treatment of Cerebral Metastases from Malignant Germ Cell Tumours, Page 249, Sophie D. Fosså
Management of Central Nervous System Metastases in Patients with Disseminated Germ Cell Tumours, Page 251, Craig R. Nichols
The Treatment of Brain Metastases from Germ Cell Cancer — A Report of the Round-Table Discussion, Pages 253-254, J.K. Joffe, C. Bradley, W.G. Jones
Dose Intensive Chemotherapy for Poor Prognosis Germ Cell Malignancies, Pages 255-260, John A. Levi, Guy Toner
Schedule Intensive Treatment for Testicular Germ Cell Tumours, Pages 261-270, Luis Paz-Ares, Stanley B. Kaye
Salvage Therapy in Metastatic Non-Seminomatous Germ Cell Tumour at the University of Texas M.D. Anderson Cancer Center, Pages 271-272, R.J. Amato, L. Finn, A. Striegel, A. Sella, J.A. Ellerhorst, A.A. Zukiwski, C.J. Logothetis
Late Relapses in Advanced Malignant Germ Cell Tumours (MGCT) Treated with Cisplatin Based Chemotherapy, Pages 273-274, L. Paz-Ares, P. Lianes, H. Cortes-Funes
The Importance of Dose Intensity in the Chemotherapy of Advanced Testicular Cancer, Page 275, N. Miyanaga, H. Akaza, K. Hattori, H. Takeshima, K. Koiso
Salvage Chemotherapy and Autologous Bone Marrow Transplantation: 9-Year Experience at Institut Gustave-Roussy, Pages 279-283, S. Culine, J.L. Pico, A. Kramar, J.P. Droz
Dose-Intensive Chemotherapy in Patients with Germ Cell Tumours: The Memorial Sloan-Kettering Cancer Center Experience, Pages 285-292, Heidi S. Hutter, Robert J. Motzer, Dean F. Bajorin, George J. Bosl
A High-Dose Carboplatin-Based Salvage Strategy for Relapsing or Refractory Germ Cell Cancer, Page 293, S. Rodenhuis, E. van der Wall, J.H. Schornagel, W.W. ten Bokkel Huinink, D.J. Richel, L.T. Vlasveld
High Dose Chemotherapy with Autologous Marrow Rescue for Germ Cell Salvage Consolidation: Vancouver Experience, Pages 295-298, Chris M.L. Coppin, Michael J. Barnett, Nevin Murray, Gordon L. Phillips
Management of Recurrent Germ Cell Tumours: Role of High Dose Chemotherapy, Page 299, Craig R. Nichols
High Dose Chemotherapy with Haemopoietic Stem Cell Support, Page 301, A. Horwich
Salvage Chemotherapy and Autologous Bone Marrow Chemotherapy for Refractory Germ Cell Malignancies, Page 303, John A. Levi
High Dose Chemotherapy Plus Stem Cell Support for Poor Risk Testicular Cancer or as Salvage Therapy for Patients with Relapsed Disease, Page 305, H.-J. Schmoll, C. Bokemeyer, W. Siegert, J. Beyer, L. Arseniev, A. Andres, H. Link, M. Freund
Salvage Chemotherapy and Autologous Stem Cell/Bone Marrow Transplantation in Germ Cell Cancer — Summary of Papers Presented and Round-Table Discussion, Pages 307-309, J.K. Joffe, C. Bradley, W.G. Jones
Surgery in Non-Seminomatous Germ Cell Tumours of the Testis, Pages 311-317, Giorgio Pizzocaro, Roberto Salvioni, Nicola Nicolai
Aortic Replacement in Retroperitoneal Lymph Node Dissection for Metastatic Germ Cell Cancer, Pages 319-323, John P. Donohue, John A. Thornhill, Richard S. Foster, Richard Bihrle
Resection of the Inferior Vena Cava or Intraluminal Tumour Thrombectomy During Retroperitoneal Lymph Node Dissection for Metastatic Germ Cell Cancer: Indications and Results, Pages 325-332, John P. Donohue, John A. Thornhill, Richard S. Foster, Randall G. Rowland, Richard Bihrle
Retroperitoneal Surgery: Management Strategies in Malignant Teratoma, Page 333, D. Kirk, S.B. Kaye
Modified Retroperitoneal Lymph Node Dissection for Testicular Tumour: Open and Laparoscopic Approach, Operative Technique and Results, Pages 335-336, A. Hobisch, K. Colleselli, O. Ennemoser, W. Horninger, G. Janetschek, S. Poisel, G. Bartsch
Late Side Effects in Patients Treated for Testicular Cancer, Pages 337-343, Nina Aass, Sophie D. Fosså
Fertility in Nerve-Sparing RPLND, Pages 345-351, John P. Donohue, Richard S. Foster
Treatment for Loss of Ejaculation after Para-Aortic Lymphadenectomy, Pages 353-358, W.F. Hendry
Second Cancer Risk Following Testicular Cancer, Pages 359-369, Flora E. van Leeuwen, Anne M. Stiggelbout, Jan F.M. Delemarre, Reinier Somers
Long-Term Toxicity after Cisplatinum-Based Chemotherapy, Pages 371-375, Mikael Rørth, Steen Werner Hansen, Gedske Daugaard
Experience of a Testicular Cancer Patient Support Group, Page 377, A. Benghiat, W. Brock
Severe Vascular Side Effects of Cisplatinum Based Chemotherapy, Page 379, F.J.F. Madden
Haemopoietic Growth Factors: An Overview, Pages 381-383, James Chang
Development of New Antiemetics, Pages 385-390, R.J. Naylor, J.A. Rudd
Strategies to Control Vomiting Caused by Anticancer Drugs, Pages 391-397, Mark G. Kris, Lorraine Baltzer, Linda Hinkley, Katherine M.W. Pisters
Chemotherapy for Testicular Cancer: Prophylactic Ciprofloxacin Reduces the Incidence of Neutropenic Pyrexia, Page 399, R. Counsell, J. Pratt, M.V. Williams
Germ Cell Tumours: Past, Present and Future, Pages 401-408, George J. Bosl, Ethan Dmitrovsky, Raju S.K. Chaganti
Is there any Relationship between Vasectomy and Testicular Cancer?, Pages 411-412, I. Appleyard
Primary Cerebral Germinoma in Children — French Society of Paediatric Oncology (SFOP) Experience, Page 413, M.C. Baranzelli, C. Patte, C. Kalifa, J.L. Brand, D. Renier, Cl. Schmitt, J.C. Gentet, J. Otten, F. Millot, P. Lutz, S. Blond, B. Coche-Dequeant, F. Flammant
NSGCTT Metastases, Page 415, C.D. Collins
A Pilot Evaluation of Peripheral Blood Stem Cell Transplants Compared to ABMT Following High Dose Chemotherapy, Page 417, Polly Edmonds, R. Tim, D. Oliver, Uma Somasundrum, Chris J. Gallagher
Clinical Features and Prognosis of Primary Mediastinal and Retroperitoneal Germ Cell Tumours Treated with Cisplatin-Based Chemotherapy, Page 419, A. Gerl, C. Clemm, P. Kohl, K. Mann, R. Lamerz, W. Wilmanns
Four Drug Combination Chemotherapy Consisting of Etoposide, Cisplatin, Bleomycin and Cyclophosphamide for Advanced Metastatic Non-Seminomatous Germ Cell Tumours, Pages 421-422, A. Gerl, C. Clemm, M. Hentrich, P. Kohl, R. Hartenstein, W. Wilmanns
Germ Cell Tumours and Carcinoma In Situ of the Testis Detected by Fine Needle Biopsy, Page 423, J.O. Grosse, H.-J. Nelde, K.-H. Bichler
Malignant Sex Cord/Stromal Tumours: A Case Report of a Metastatic Sertoli-Leydig Cell Tumour of the Testis, Pages 425-427, J.O. Grosse, D.M. Wilbert, K.-H. Bichler, H. Pressler
Phase III Trial of Early Intensified Chemotherapy (HDCT) with Autologous Bone Marrow Transplantation (ABMT) in First Line Treatment of Poor Risk Non-Seminomatous Germ Cell Tumours (NSGCT): Long Term Results of a Randomised Trial, Pages 429-430, J.F. Héron, J.P. Droz, J.L. Pico, P. Biron, P. Kerbrat, H. Curé, C. Chevreau, B. Chevallier, P. Fargeot, J. Bouzy, A. Kramar
Estimation of 12p Copy Number in Paraffin-Embedded Tissue Sections of Germ Cell Tumours by In Situ Hybridization of a Microdissected 12p Probe, Page 431, J. Melamed, E. Rodriguez, V. Reuter, G.J. Bosl, R.S.K. Chaganti
An Evaluation of a Testicular Self-Examination Video, Page 433, R.C. Murray, S.M. Crawford, C.P. Shinn
High Dose Chemotherapy with Autologous Bone Marrow Transplantation for Advanced Germ Cell Tumours, Page 435, Tatsuya Okano, Hiroyuki Ishii, Shigeo Isaka, Rousaku Yasuda, Jun Shimazaki
Localised Gonadal Non-Seminomatous Germ Cell Tumours — French Society of Pediatric Oncology Experience (SFOP), Page 437, C. Patte, M.C. Baranzelli, E. Quintana, H. Rubie, A. Thyss, C. Behar, P. Boutard, J.P. Vannier, F. Flamant
Salvage Therapy in Refractory/Relapsed Germ Cell Tumours: Etoposide, Ifosfamide and Cisplatin (VIP), Pages 439-440, L. Paz-Ares, M. Lopez-Brea, F. Rivera, P. Lianes, H. Cortes-Funes
Preliminary Results of BOP–VIP Protocol in Poor Risk “Worst Prognosis” Non-Seminomatous Germ Cell Tumours of Testis, Page 441, V. Raina, N.K. Shukla, N.P. Gupta, G.K. Rath
Cancer in Cryptorchid Testes at IRCH All India Institute of Medical Sciences, New Delhi 1987–1992, Page 443, V. Raina, N.K. Shulka, G.K. Rath, N.P. Gupta
Weekly Cisplatinum Combination Chemotherapy Regimes for Relapsed/Poorly Responding Metastatic Malignant Germ Cell Tumours, Page 445, M.A. Raja, R.T.D. Oliver, C.J. Gallagher
The Results of a Surveillance Study in Stage I Non-Seminomatous Germ Cell Tumours of the Testis, Page 447, S. Tekgul, H. özen, A. Sahin, A. Ergen, D. Remzi
HCG Positive Seminoma, Pages 449-450, L. Weißbach, R. Bussar-Maatz
Index, Pages 451-456