Genomic and Personalized Medicine. Volumes I & II

Content: 
Copyright Page, Page ii
Acknowledgements, Page xxix
Advisory Board, Page xxxix
Foreword, Pages xxv-xxvi
Preface, Pages xxvii-xxviii
Contributors, Pages xli-xlvii
Chapter 1 - Organization, Variation and Expression of the Human Genome as a Foundation of Genomic and Personalized Medicine, Pages 1,3,4-21, Huntington F. Willard
Chapter 2 - Concepts of Population Genomics, Pages 22-32, Mike E. Weale, David B. Goldstein
Chapter 3 - Genomic Approaches to Complex Disease, Pages 33-46, Desmond J. Smith, Aldons J. Lusis
Chapter 4 - Human Health and Disease: Interaction Between the Genome and the Environment, Pages 47-59, Kenneth Olden
Chapter 5 - Epigenomics and Its Implications for Medicine, Pages 60-73, Moshe Szyf
Chapter 6 - Systems Biology and the Emergence of Systems Medicine, Pages 74-85, Nathan D. Price, Lucas B. Edelman, Inyoul Lee, Hyuntae Yoo, Daehee Hwang, George Carlson, David J. Galas, James R. Heath, Leroy Hood
Chapter 7 - DNA Sequencing for the Detection of Human Genome Variation and Polymorphism, Pages 87,88-100, Samuel Levy, Yu-Hui Rogers
Chapter 8 - Genome-Wide Association Studies and Genotyping Technologies, Pages 101-107, Kevin V. Shianna
Chapter 9 - Copy Number Variation and Human Health, Pages 108-119, Charles Lee, Courtney Hyland, Arthur S. Lee, Shona Hislop, Chunhwa Ihm
Chapter 10 - Inter-Species Comparative Sequence Analysis: A Tool for Genomic Medicine, Pages 120-130, Anthony Antonellis, Eric D. Green
Chapter 11 - DNA Methylation Analysis: Providing New Insight into Human Disease, Pages 131-142, Susan Cottrell, Theo deVos, Juergen Distler, Carolina Haefliger, Ralf Lesche, Achim Plum, Matthias Schuster
Chapter 12 - Transcriptomics: Translation of Global Expression Analysis to Genomic Medicine, Pages 143-156, Michelle M. Kittleson, Rafael Irizarry, Bettina Heidecker, Joshua M. Hare
Chapter 13 - DNA Microarrays in Biological Discovery and Patient Care, Pages 157-172, Andrew J. Yee, Sridhar Ramaswamy
Chapter 14 - Proteomics: The Deciphering of the Functional Genome, Pages 173-179, Li-Rong Yu, Nicolas A. Stewart, Timothy D. Veenstra
Chapter 15 - Comprehensive Metabolic Analysis for Understanding of Disease Mechanisms, Pages 180-192, Christopher B. Newgard, Robert D. Stevens, Brett R. Wenner, Shawn C. Burgess, Olga Ilkayeva, Michael J. Muehlbauer, A. Dean Sherry, James R. Bain
Chapter 16 - Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics, Pages 193-203, Bjorn T. Gjertsen, James B. Lorens
Chapter 17 - Bioinformatic and Computational Analysis for Genomic Medicine, Pages 205,206-225, Atul J. Butte
Chapter 18 - Fundamentals and History of Informatics for Genomic and Personalized Medicine, Pages 226-232, A. Jamie Cuticchia
Chapter 19 - Electronic Medical Records in Genomic Medicine Practice and Research, Pages 233-241, Glenn S. Gerhard, Robert D. Langer, David J. Carey, Walter F. Stewart
Chapter 20 - Clinical Decision Support in Genomic and Personalized Medicine, Pages 242-251, Kensaku Kawamoto, David F. Lobach
Chapter 21 - Online Health Information Retrieval by Consumers and the Challenge of Personal Genomics, Pages 252-257, Mark S. Boguski
Chapter 22 - Translational Genomics: From Discovery to Clinical Practice, Pages 259,261,262-274, Geoffrey S. Ginsburg
Chapter 23 - Principles of Study Design, Pages 275-283, Peter Grass
Chapter 24 - Biobanking in the Post-Genome Era, Pages 284-298, Theresa Puifun Chow, Chia Kee Seng, Per Hall, Edison T. Liu
Chapter 25 - Application of Biomarkers in Human Population Studies, Pages 299-307, Stefano Bonassi, Monica Neri
Chapter 26 - Validation of Candidate Protein Biomarkers, Pages 308-320, Ingibjörg Hilmarsdóttir, Nader Rifai
Chapter 27 - Pharmacogenetics and Pharmacogenomics, Pages 321-334, Iris Grossman, David B. Goldstein
Chapter 28 - The Role of Genomics and Genetics in Drug Discovery and Development, Pages 335-342, Robert I. Tepper, Ronenn Roubenoff
Chapter 29 - Role of Pharmacogenomics in Drug Development, Pages 343-356, Colin F. Spraggs, Beena T. Koshy, Mark R. Edbrooke, Allen D. Roses
Chapter 30 - Clinical Implementation of Translational Genomics, Pages 357-366, Wendy K. Chung
Chapter 31 - Translating Innovation in Diagnostics: Challenges and Opportunities, Pages 367-377, Matthew P. Brown, Myla Lai-Goldman, Paul R. Billings
Chapter 32 - The Role of Genomics in Enabling Prospective Health Care, Pages 378-385, Ralph Snyderman
Chapter 33 - From Sequence to Genomic Medicine: Genome Policy Considerations, Pages 387,388-400, Susanne B. Haga
Chapter 34 - Educational Strategies in Genomic Medicine, Pages 401-413, Charles J. Epstein
Chapter 35 - Federal Regulation of Genomic Medicine, Pages 414-423, Janet Woodcock
Chapter 36 - Economic Issues and Genomic Medicine, Pages 424-433, David L. Veenstra,, Louis P. Garrison,, Scott D. Ramsey
Chapter 37 - Public–Private Interactions in Genomic Medicine: Research and Development, Pages 434-444, Subhashini Chandrasekharan,, Noah C. Perin,, Ilse R. Wiechers,, Robert Cook-Deegan
Chapter 38 - What Is Public Health Genomics?, Pages 445,446-453, Alison Stewart, Ron Zimmern
Chapter 39 - Why Do We Need Public Health in the Era of Genomic Medicine?, Pages 454-460, Muin J. Khoury, Marta Gwinn
Chapter 40 - Principles of Human Genome Epidemiology, Pages 461-469, Marta Gwinn, Muin J. Khoury
Chapter 41 - Genomics and Population Screening: Example of Newborn Screening, Pages 470-480, John D. Thompson, Michael Glass
Chapter 42 - Family History: A Bridge Between Genomic Medicine and Disease Prevention, Pages 481-492, Maren T. Scheuner, Paula W. Yoon
Chapter 43 - Molecular Imaging as a Paradigm for Genomic and Personalized Medicine, Pages 493,494-499, Ralph Weissleder
Chapter 44 - PET Imaging in Genomic Medicine, Pages 500-511, Vikas Kundra, Osama Mawlawi
Chapter 45 - MRI for Molecular ImagingApplications: Overview, Perspectives, and Challenges, Pages 512-523, Dmitri Artemov
Chapter 46 - Fluorescence Imaging: Overview and Applications in Biomedical Research, Pages 524-531, Vasilis Ntziachristos
Chapter 47 - Imaging Genetics: Integration of Neuroimaging and Genetics in the Search for Predictive Markers, Pages 532-537, Ahmad R. Hariri
Chapter 48 - Viral Chip Technology in Genomic Medicine, Pages 538-561, Zeno Földes-Papp
Vaccines Against Infectious Diseases: A Biotechnology-Driven Evolution, Pages 562-572, Vega Masignani, Hervé Tettelin, Rino Rappuoli
Chapter 50 - Cancer Vaccines: Some Basic Considerations, Pages 573-589, Hans-Georg Rammensee, Harpreet Singh-Jasuja, Niels Emmerich, Steve Pascolo
Chapter 51 - Biosensors for the Genomic Age, Pages 590-598, Meghan B. O'Donoghue, Lin Wang, Yan Chen, Gang Yao, Weihong Tan
Chapter 52 - Stem Cells, Pages 599-609, Rikkert L. Snoeckx, Kris Van Den Bogaert, Catherine M. Verfaillie
Chapter 53 - Gene Therapy, Pages 610-619, James M. Wilson, Nelson A. Wivel
Chapter 54 - The Genomics of Hypertension, Pages 621,623,624-633, Chana Yagil, Yoram Yagil
Chapter 55 - Lipoprotein Disorders, Pages 634-651, Sekar Kathiresan, Daniel J. Rader
Chapter 56 - Reactive oxygen species signals leading to vascular dysfunction and atherosclerosis, Pages 652-664, Nageswara R. Madamanchi, Aleksandr E. Vendrov, Marschall S. Runge
Chapter 57 - Genomics of Myocardial Infarction, Pages 665-679, Carlos A. Hubbard, Eric J. Topol
Chapter 58 - Acute Coronary Syndromes, Pages 680-691, L. Kristin Newby
Chapter 59 - Heart Failure in the Era of Genomic Medicine, Pages 692-704, Ivor J. Benjamin, Jeetendra Patel
Chapter 60 - Application of Genomic Methodology for Assessment of Cardiac Transplant Rejection, Pages 705-715, Michael Pham, Mario C. Deng, Jay Wohlgemuth, Thomas Quertermous
Chapter 61 - Hypertrophic Cardiomyopathy in the Era of Genomic Medicine, Pages 716-728, J. Martijn Bos, Steve R. Ommen, Michael J. Ackerman
Chapter 62 - Genetics and Genomics of Arrhythmias, Pages 729-754, Jeffrey A. Towbin, Matteo Vatta
Chapter 63 - Hemostasis and Thrombosis, Pages 755-772, Richard C. Becker,, Felicita Andreotti
Chapter 64 - Genetic Polymorphisms in Peripheral Arterial Disease, Role of Genomic Methodologies, Pages 773-780, Ayotunde O. Dokun, Brian H. Annex
Chapter 65 - Genomics of Congenital Heart Disease, Pages 781-793, Jessie H. Conta, Roger E. Breitbart
Chapter 66 - Genomics of Perioperative and Procedural Medicine, Pages 794-805, Simon C. Body, Mihai V. Podgoreanu, Debra A. Schwinn
Chapter 67 - Cancer Genes, Genomes, and the Environment, Pages 807,808-817, Robert L. Strausberg
Chapter 68 - Immune Cells and the Tumor Microenvironment, Pages 818-829, David S. Hsu, Michael Morse, Timothy Clay, Gayathri Devi, H. Kim Lyerly
Chapter 69 - Lymphomas, Pages 830-843, Lisa Rimsza
Chapter 70 - Genomics in Leukemias, Pages 844-855, Lars Bullinger, Hartmut Dohner, Jonathan R. Pollack
Chapter 71 - Genomics of Lung Cancer, Pages 856-868, Hasmeena Kathuria, Avrum Spira, Jerome Brody
Chapter 72 - Breast Cancer and Genomic Medicine, Pages 869-878, Erich S. Huang, Andrew T. Huang
Chapter 73 - Colorectal Cancer, Pages 879-897, G.L. Wiesner, T.P. Slavin, J.S. Barnholtz-Sloan
Chapter 74 - Prostate Cancer, Pages 898-912, Phillip G. Febbo, Philip W. Kantoff
Chapter 75 - Molecular Biology of Ovarian Cancer, Pages 913-920, Tanja Pejovic, Matthew L. Anderson, Kunle Odunsi
Chapter 76 - Pancreatic Neoplasms, Pages 921-930, Asif Khalid, Kevin McGrath
Chapter 77 - The Multiple Endocrine Neoplasia Syndromes, Pages 931-944, Y. Nancy You, Vipul Lakhani, Samuel A. Wells
Chapter 78 - Genomics of Head and Neck Cancer, Pages 945-955, Giovana R. Thomas, Yelizaveta Shnayder
Chapter 79 - Genomic Medicine, Brain Tumors and Gliomas, Pages 956-966, Sean E. Lawler, E. Antonio Chiocca
Chapter 80 - Molecular Therapeutics of Melanoma, Pages 967-976, Jiaqi Shi, Yonmei Feng, Robert S. Krouse,, Stanely Leong, Mark A. Nelson
Chapter 81 - Emerging Concepts in Metastasis, Pages 977-989, Nigel P.S. Crawford, Kent W. Hunter
Chapter 82 - Diagnostic-Therapeutic Combinations in the Treatment of Cancer, Pages 990-1007, Jeffrey S. Ross
Chapter 83 - Environmental Exposures and the Emerging Field of Environmental Genomics, Pages 1009,1010-1016, David A. Schwartz
Chapter 84 - Molecular Basis of Rheumatoid Arthritis, Pages 1017-1031, Robert M. Plenge, Michael E. Weinblatt
Chapter 85 - “Omics” in the Study of Multiple Sclerosis, Pages 1032-1039, Francisco J. Quintana, Howard L. Weiner
Chapter 86 - Inflammatory Bowel Disease, Pages 1040-1055, Ad A. van Bodegraven and Cisca Wijmenga
Chapter 87 - Glomerular Disorders, Pages 1056-1066, Tadashi Yamamoto, Hidehiko Fujinaka, Visith Thongboonkerd
Chapter 88 - Spondyloarthropathies, Pages 1067-1083, Dirk Elewaut, Filip De Keyser, Filip Van den Bosch, Dieter Deforce, Herman Mielants
Chapter 89 - Asthma Genomics, Pages 1084-1097, Scott T. Weiss, Benjamin A. Raby, Juan C. Celedón
Chapter 90 - Genomic Aspects of Chronic Obstructive Pulmonary Disease, Pages 1098-1109, Peter J Barnes
Chapter 91 - Genomic Determinants of Interstitial Lung Disease, Pages 1110-1121, Paul W. Noble and Mark P. Steele
Chapter 92 - Peptic Ulcer Disease, Pages 1122-1137, John Holton
Chapter 93 - Cirrhosis in the Era of Genomic Medicine, Pages 1138-1154, N.A. Shackel, K. Patel, J. McHutchison
Chapter 94 - Systemic Sclerosis, Pages 1155-1168, Ulf Müller-Ladner
Chapter 95 - Genomic Medicine and Obesity, Pages 1169,1170-1186, J. Alfredo Martínez
Chapter 96 - Diabetes, Pages 1187-1193, Maggie Ng, Nancy J. Cox
Chapter 97 - Metabolic Syndrome, Pages 1194-1203, Rebecca L. Pollex, Robert A. Hegele
Chapter 98 - Nutrition and Diet in the Era of Genomics, Pages 1204-1220, Jose M. Ordovas, Dolores Corella
Chapter 99 - The Genetic Approach to Dementia, Pages 1221,1222-1232, Robert L. Nussbaum
Chapter 100 - Parkinson’s Disease: Genomic Perspectives, Pages 1233-1242, Shushant Jain, Andrew B. Singleton
Chapter 101 - Epilepsy Predisposition and Pharmacogenetics, Pages 1243-1255, Nicole M. Walley, David B. Goldstein
Chapter 102 - Ophthalmology, Pages 1256-1264, Janey L. Wiggs
Chapter 103 - The Genomic Basis of Neuromuscular Disorders, Pages 1265-1281, Erynn S. Gordon, Eric P. Hoffman
Chapter 104 - Psychiatric Disorders, Pages 1282-1288, Stephan Züchner, Ranga Krishnan
Chapter 105 - Genomics and Depression, Pages 1289-1298, Brigitta Bondy
Chapter 106 - Bipolar Disorder in the Era of Genomic Psychiatry, Pages 1299-1311, Ayman H. Fanous, Frank Middleton, Carlos N. Pato, Michele T. Pato
Chapter 107 - Genomic Approaches to the Host Response to Pathogens, Pages 1313,1314-1323, M. Frances Shannon
Chapter 108 - Genomic Medicine and AIDS, Pages 1324-1339, Thomas Hirtzig, Yves Lévy, Jean-François Zagury
Chapter 109 - Viral Genomics and Antiviral Drugs, Pages 1340-1346, Roberto Patarca
Chapter 110 - Host Genomics and Bacterial Infections, Pages 1347-1361, Melissa D. Johnson, Mihai Netea
Chapter 111 - Sepsis and the Genomic Revolution, Pages 1362-1374, Christopher W. Woods, Robert J. Feezor, Stephen F. Kingsmore
Chapter 112 - Diagnosis, Management and Disease Mechanisms of Hepatitis in the Era of Genomic Medicine, Pages 1375-1389, N.A. Shackel, K. Patel, J. McHutchison
Glossary, Pages 1391-1406
Index, Pages 1407-1478