Genetics: Analysis and Principles

Front Cover
Title Page
Copyright Page
Brief Contents
Table of Contents
Preface
A Visual Guide to Genetics: Analysis & Principles
PART I: INTRODUCTION
	1 OVERVIEW OF GENETICS
		1.1 The Relationship Between Genes and Traits
		1.2 Fields of Genetics
PART II: PATTERNS OF INHERITANCE
	2 MENDELIAN INHERITANCE
		2.1 Mendel’s Laws of Inheritance
		2.2 Probability and Statistics
	3 REPRODUCTION AND CHROMOSOME TRANSMISSION
		3.1 General Features of Chromosomes
		3.2 Cell Division
		3.3 Sexual Reproduction
		3.4 The Chromosome Theory of Inheritance and Sex Chromosomes
	4 EXTENSIONS OF MENDELIAN INHERITANCE
		4.1 Inheritance Patterns of Single Genes
		4.2 Gene Interactions
	5 NON-MENDELIAN INHERITANCE
		5.1 Maternal Effect
		5.2 Epigenetic Inheritance
		5.3 Extranuclear Inheritance
	6 GENETIC LINKAGE AND MAPPING IN EUKARYOTES
		6.1 Linkage and Crossing Over
		6.2 Genetic Mapping in Plants and Animals
		6.3 Genetic Mapping in Haploid Eukaryotes
		6.4 Mitotic Recombination
	7 GENETIC TRANSFER AND MAPPING IN BACTERIA AND BACTERIOPHAGES
		7.1 Genetic Transfer and Mapping in Bacteria
		7.2 Intragenic Mapping in Bacteriophages
	8 VARIATION IN CHROMOSOME STRUCTURE AND NUMBER
		8.1 Variation in Chromosome Structure
		8.2 Variation in Chromosome Number
		8.3 Natural and Experimental Ways to Produce Variations in Chromosome Number
PART III: MOLECULAR STRUCTURE AND REPLICATION OF THE GENETIC MATERIAL
	9 MOLECULAR STRUCTURE OF DNA AND RNA
		9.1 Identification of DNA as the Genetic Material
		9.2 Nucleic Acid Structure
	10 CHROMOSOME ORGANIZATION AND MOLECULAR STRUCTURE
		10.1 Viral Genomes
		10.2 Bacterial Chromosomes
		10.3 Eukaryotic Chromosomes
	11 DNA REPLICATION
		11.1 Structural Overview of DNA Replication
		11.2 Bacterial DNA Replication
		11.3 Eukaryotic DNA Replication
PART IV: MOLECULAR PROPERTIES OF GENES
	12 GENE TRANSCRIPTION AND RNA MODIFICATION
		12.1 Overview of Transcription
		12.2 Transcription in Bacteria
		12.3 Transcription in Eukaryotes
		12.4 RNA Modification
	13 TRANSLATION OF mRNA
		13.1 The Genetic Basis for Protein Synthesis
		13.2 Structure and Function of tRNA
		13.3 Ribosome Structure and Assembly
		13.4 Stages of Translation
	14 GENE REGULATION IN BACTERIA AND BACTERIOPHAGES
		14.1 Transcriptional Regulation
		14.2 Translational and Posttranslational Regulation
		14.3 Riboswitches
		14.4 Gene Regulation in the Bacteriophage Reproductive Cycle
	15 GENE REGULATION IN EUKARYOTES
		15.1 Regulatory Transcription Factors
		15.2 Chromatin Remodeling, Histone Variation, and Histone Modification
		15.3 DNA Methylation
		15.4 Insulators
		15.5 Regulation of RNA Processing, RNA Stability, and Translation
	16 GENE MUTATION AND DNA REPAIR
		16.1 Consequences of Mutation
		16.2 Occurrence and Causes of Mutation
		16.3 DNA Repair
	17 RECOMBINATION AND TRANSPOSITION AT THE MOLECULAR LEVEL
		17.1 Homologous Recombination
		17.2 Site-Specific Recombination
		17.3 Transposition
PART V: GENETIC TECHNOLOGIES
	18 RECOMBINANT DNA TECHNOLOGY
		18.1 Gene Cloning Using Vectors
		18.2 Polymerase Chain Reaction
		18.3 DNA Libraries and Blotting Methods
		18.4 Methods for Analyzing DNA- and RNA- Binding Proteins
		18.5 DNA Sequencing and Site-Directed Mutagenesis
	19 BIOTECHNOLOGY
		19.1 Uses of Microorganisms in Biotechnology
		19.2 Genetically Modified Animals
		19.3 Reproductive Cloning and Stem Cells
		19.4 Genetically Modified Plants
		19.5 Human Gene Therapy
	20 GENOMICS I: ANALYSIS OF DNA
		20.1 Overview of Chromosome Mapping
		20.2 Cytogenetic Mapping Via Microscopy
		20.3 Linkage Mapping Via Crosses
		20.4 Physical Mapping Via Cloning
		20.5 Genome-Sequencing Projects
	21 GENOMICS II: FUNCTIONAL GENOMICS, PROTEOMICS, AND BIOINFORMATICS
		21.1 Functional Genomics
		21.2 Proteomics
		21.3 Bioinformatics
PART VI: GENETIC ANALYSIS OF INDIVIDUALS AND POPULATIONS
	22 MEDICAL GENETICS AND CANCER
		22.1 Inheritance Patterns of Genetic Diseases
		22.2 Detection of Disease-Causing Alleles
		22.3 Prions
		22.4 Genetic Basis of Cancer
	23 DEVELOPMENTAL GENETICS
		23.1 Overview of Animal Development
		23.2 Invertebrate Development
		23.3 Vertebrate Development
		23.4 Plant Development
		23.5 Sex Determination in Animals and Plants
	24 POPULATION GENETICS
		24.1 Genes in Populations and the Hardy-Weinberg Equation
		24.2 Factors That Change Allele and Genotype Frequencies in Populations
		24.3 Sources of New Genetic Variation
	25 QUANTITATIVE GENETICS
		25.1 Quantitative Traits
		25.2 Polygenic Inheritance
		25.3 Heritability
	26 EVOLUTIONARY GENETICS
		26.1 Origin of Species
		26.2 Phylogenetic Trees
		26.3 Molecular Evolution
		26.4 Evo-Devo: Evolutionary Developmental Biology
Appendix A: Experimental Techniques
Appendix B: Solutions to Even-Numbered Problems
Glossary
Credits
Index