Genetics Meets Metabolomics: from Experiment to Systems Biology

Front Matter....Pages i-xviii
Introduction....Pages 1-4
Pre-conditions for High Quality Biobanking in Large Human Epidemiological Cohorts for Metabolomics and Other – Omics Studies....Pages 5-11
Assay Tools for Metabolomics....Pages 13-38
Statistical Methods in Genetic and Molecular Epidemiology and Their Application in Studies with Metabolic Phenotypes....Pages 39-56
Ultrahigh Resolution Mass Spectrometry Based Non-targeted Microbial Metabolomics....Pages 57-71
Metabolomic Systems Biology of Protozoan Parasites....Pages 73-84
Mouse Genetics and Metabolic Mouse Phenotyping....Pages 85-106
Metabolomics in Animal Breeding....Pages 107-123
Metabolomics Applications in Human Nutrition....Pages 125-137
Metabolomics for the Individualized Therapy of Androgen Deficiency Syndrome in Male Adults....Pages 139-155
Systems Biology Resources Arising from the Human Metabolome Project....Pages 157-175
Understanding Cancer Metabolism Through Global Metabolomics....Pages 177-190
Genetic and Metabolic Determinants of Fatty Acid Chain Length and Desaturation, Their Incorporation into Lipid Classes and Their Effects on Risk of Vascular and Metabolic Disease....Pages 191-231
Mapping Metabolomic Quantitative Trait Loci (mQTL): A Link Between Metabolome-Wide Association Studies and Systems Biology....Pages 233-254
Metabolic Traits as Intermediate Phenotypes....Pages 255-264
Genome-Wide Association Studies with Metabolomics....Pages 265-279
Systems Biology Meets Metabolism....Pages 281-313
Back Matter....Pages 315-318