Genetic Mosaics and Chimeras in Mammals

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Reversion of Malignancy and Normalized Differentiation of Teratocarcinoma Cells in Chimeric Mice....Pages 3-25
Viable Chimaeras Produced from Normal and Parthenogenetic Mouse Embryos....Pages 27-32
Ovarian Teratomas in Mice are Derived from Oocytes That Have Completed the First Meiotic Division....Pages 33-37
Growth Control in Chimaeras....Pages 39-49
Attempts at Locating the Site of Action of Genes Affecting Behavior....Pages 51-58
Fine Structure of Cells in Embryos Chimeric for Mutant Genes at the T/t Locus....Pages 59-80
An Analysis of Differentiation in Coaggregation Cultures between Mouse Neuronal and Tumor Cells....Pages 81-95
The Use of Mosaics and Experimental Chimeras to Study the Pathogenesis of Neoplasia....Pages 97-110
Antibodies to Allozymes as Potential Cell Markers for Chimeric Mouse Studies....Pages 111-122
Front Matter....Pages 123-123
Reproduction in Single-Sex Chimeras....Pages 125-134
Germ Cells in XX ↔ XY Mouse Chimeras....Pages 135-142
Use of the Sex Reversed Gene (Sxr) to Investigate Functional Sex Reversal and Gonadal Determination in Mammals....Pages 143-163
Why not Androgynes among Mammals?....Pages 165-181
Cell Interactions in the Sex Organs of Sex Reversed Mice Heterozygous for Testicular Feminization....Pages 183-193
Spontaneous Sex Mosaicism in Balb/cWt Mice....Pages 195-208
Evidence from Mutable Genes Concerning the Origin of the Germ Line....Pages 209-224
Front Matter....Pages 225-225
Bimodal Distribution of α-Galactosidase Activities in Mouse Embryos....Pages 227-237
Biochemical Studies on X-Chromosome Activity in Preimplantation Mouse Embryos....Pages 239-246
Hypoxanthine Guanine Phosphoribosyl Transferase Expression in Early Mouse Development....Pages 247-260
The Direct Demonstration of an X-Chromosome Dosage Effect Prior to Inactivation....Pages 261-267
Front Matter....Pages 225-225
Use of Teratocarcinoma Stem Cells as a Model System for the Study of X-Chromosome Inactivation In Vitro ....Pages 269-295
The Stability of X-Chromosome Inactivation: Studies with Mouse-Human Cell Hybrids and Mouse Teratocarcinomas....Pages 297-328
Studies of Human-Mouse Cell Hybrids with Respect to X-Chromosome Inactivation....Pages 329-337
Front Matter....Pages 339-339
Preferential Inactivation of the Paternally Derived X Chromosome in Mice....Pages 341-360
Preferential Expression of the Maternally Derived X Chromosome in Extraembryonic Tissues of the Mouse....Pages 361-377
In Search of Nonrandom X Inactivation: Studies of the Placenta from Newborns Heterozygous for Glucose-6-Phosphate Dehydrogenase....Pages 379-391
The Use of Mouse X-Autosome Translocations in the Study of X-Inactivation Pathways and Nonrandomness....Pages 393-416
Selection and Cell Communication as Determinants of Female Phenotype....Pages 417-432
Front Matter....Pages 433-433
Clonal Growth Versus Cell Mingling....Pages 435-444
Combinatorial and Computer Analysis of Random Mosaics....Pages 445-463
Data Analysis of Four X-Chromosome Inactivation Experiments....Pages 465-477
Back Matter....Pages 479-485