Genetic Dissection of Complex Traits

Content: 
Contributors
Pages xv-xvii

Preface
Pages xix-xx
D.C. Rao, M.A. Province

Acknowledgments
Page xxi

1 Newton Morton: The Wisconsin years Review Article
Pages 3-5
James F. Crow

Newton Morton's influence on genetics: The Morton number Review Article
Pages 7-10
Daniel E. Weeks

3 Genetic dissection of complex traits: An overview Review Article
Pages 13-34
D.C. Rao

4 Familial resemblance and heritability Review Article
Pages 35-44
Treva K. Rice, Ingrid B. Borecki

5 Linkage and association: Basic concepts Review Article
Pages 45-66
Ingrid B. Barecki, Brian K. Suarez

6 Definition of the phenotype Review Article
Pages 69-76
John P. Rice, Nancy L. Saccone, Erik Rasmussen

7 Genotyping for human whole-genome scans: Past, present, and future Review Article
Pages 77-96
James L. Weber, Karl W. Broman

8 The lod score method Review Article
Pages 99-113
John P. Rice, Nancy L. Saccone, Jonathan Corbett

9 Extension of the lod score: The mod score Review Article
Pages 115-124
Françoise Clerget-Darpoux

10 Major strengths and weaknesses of the lod score method Review Article
Pages 125-132
Jurg Ott

11 Overview of model-free methods for linkage analysis Review Article
Pages 135-150
Robert C. Elston, Heather J. Cordell

12 Variance component methods for detecting complex trait loci Review Article
Pages 151-181
John Blangero, Jeff T. Williams, Laura Almasy

13 Linkage and association with structural relationships Review Article
Pages 183-190
Michael A. Province

14 The future of genetic case-control studies Review Article
Pages 191-212
Nicholas J. Schork, Dani Fallin, Bonnie Thiel, Xiping Xu, Ulrich Broeckel, Howard J. Jacob, Daniel Cohen

15 Cost of linkage versus association methods Review Article
Pages 213-221
Christopher I. Amos, Grier Page

16 Genotype-environment interaction in transmission disequilibrium tests Review Article
Pages 223-240
Lindon J. Eaves, Patrick Sullivan

17 Major strengths and weaknesses of model-free methods Review Article
Pages 241-251
David E. Goldgar

18 Meta-analysis for model-free methods Review Article
Pages 255-272
Chi Gu, Michael A. Province, D.C. Rao

19 Classification methods for confronting heterogeneity Review Article
Pages 273-286
Michael A. Province, W.D. Shannon, D.C. Rao

20 Applications of neural networks for gene finding Review Article
Pages 287-297
Andrea Sherriff, Jurg Ott

21 Genome partitioning and whole-genome analysis Review Article
Pages 299-322
Nicholas J. Schorki

22 Deciphering the genetic architecture of a multivariate phenotype Review Article
Pages 323-347
Saurabh Ghosh, Partha P. Majumder

23 On the resolution and feasibility of genome scanning approaches Review Article
Pages 351-391
Joseph D. Terwilliger

24 The role of interacting determinants in the localization of genes Review Article
Pages 393-412
W.James Gauderman, Duncan C. Thomas

25 Linkage disequilibrium mapping: The role of population history, size, and structure Review Article
Pages 413-437
N.H. Chapman, E.A. Thompson

26 Optimum study designs Review Article
Pages 439-457
Chi Gu, D.C. Rao

27 One-stage versus two-stage strategies for genome scans Review Article
Pages 459-471
Xiuqing Guo, Robert C. Elston

28 Significance levels in genome scans Review Article
Pages 475-486
Glenys Thomson

29 False positives and false negatives in genome scans Original Research Article
Pages 487-498
D.C. Rao, Chi Gu

30 Sequential methods of analysis for genome scans Original Research Article
Pages 499-514
Michael A. Province

31 From genetics to mechanism of disease liability Review Article
Pages 517-533
Jean-Marc Lalouel

32 Complex inheritance: The 21st century Review Article
Pages 535-543
Newton E. Morton

Appendix
Pages 545-568

Subject index
Pages 569-583