Genetic and molecular aspects of sports performance

Genetic and Molecular Aspects of Sport Performance......Page 5
Contents......Page 7
List of Contributors......Page 9
Foreword......Page 13
Preface......Page 14
Part 1 The Science of Genomics and Genetics......Page 17
1 The Human Genome and Epigenome......Page 19
2 Mitochondrial Medicine in Health and Disease: Interface Between Athletic Performance and Therapeutics......Page 30
3 Characterizing the Extent of Human Genetic Variation for Performance-Related Traits......Page 49
4 Current Proteome Profiling Methods......Page 62
5 Bioinformatics and Public Access Resources......Page 74
6 Search for Genes Influencing Complex Traits......Page 86
Part 2 Evidence from Genetic Epidemiology Studies......Page 95
7 Genetic Epidemiology, Physical Activity, and Inactivity......Page 97
8 Role of Genetics Factors in Sport Performance: Evidence from Family Studies......Page 106
9 Twin Studies in Sport Performance......Page 117
10 Twin and Family Studies of Training Responses......Page 126
11 Ethnic Differences in Sport Performance......Page 137
12 Selection Experiments in Rodents to Define the Complexity and Diversity of Endurance Capacity......Page 149
Part 3 Contributions of Specific Genes and Markers......Page 165
13 Genes and Endurance Performance......Page 167
14 Genes and Strength and Power Phenotypes......Page 175
15 Genes and Response to Training......Page 193
16 Genetic Determinants of Exercise Performance: Evidence from Transgenic and Null Mouse Models......Page 201
17 The ACE Gene and Performance......Page 211
18 The ACTN3 Gene and Human Performance......Page 220
19 Mitochondrial DNA Sequence Variation and Performance......Page 231
20 Genes, Exercise, and Lipid Metabolism......Page 243
21 Genes, Exercise, and Glucose and Insulin Metabolism......Page 256
22 Genes, Exercise, and Cardiovascular Phenotypes......Page 265
23 Genes, Exercise, and Protein Metabolism......Page 278
24 The Regulation of Physical Activity by Genetic Mechanisms: Is There a Drive to Be Active?......Page 299
25 Genes, Exercise, and Psychological Factors......Page 310
Part 4 Systems Biology of Exercise and Training......Page 323
26 A Primer on Systems Biology, as Applied to Exercise Physiology and Metabolism......Page 325
27 Systems Biology Through Time Series Data—A Strength of Muscle Remodeling......Page 335
28 Proteomics in Exercise Training Research......Page 346
29 The Influence of Physical Exercise on Adult Stem Cells......Page 359
Part 5 Ethical and Societal Implications......Page 367
30 Genetics and Ethics in Elite Sport......Page 369
31 Genes and Talent Selection......Page 378
32 Performance Enhancement by Gene Doping......Page 389
33 Bioethical Concerns in a Culture of Human Enhancement......Page 399
A......Page 409
C......Page 410
D......Page 411
E......Page 412
G......Page 413
I......Page 414
M......Page 415
N......Page 416
P......Page 417
S......Page 418
T......Page 419
Z......Page 420