Genetic Analysis: A History of Genetic Thinking

Cover......Page 1
Half-title......Page 3
Title......Page 7
Copyright......Page 8
Contents......Page 11
Figures......Page 13
Acknowledgments......Page 15
Introduction......Page 17
Part I From reproduction and generation to heredity......Page 27
1 The biologization of inheritance......Page 30
Natural taxonomies......Page 33
From Systema naturae to hybridization......Page 34
From Histoire naturelle to morphogenetics......Page 37
Nuclear continuity and transmission......Page 39
Mendel in context......Page 41
A well-designed experiment......Page 44
The establishment of genetic analysis......Page 48
Mendel in perspective......Page 50
Part II Faktoren in search of meaning......Page 55
Pangenes and Faktoren......Page 60
The struggle with the conception of genetic analysis......Page 65
The Presence and Absence Hypothesis......Page 68
4 The demise of the unit character......Page 74
Types or traits?......Page 77
Stability of Mendelian factors......Page 80
Darwinian continuous evolution......Page 82
The "genotype conception"......Page 83
Something......Page 84
Part III The chromosome theory of inheritance......Page 91
5 Chromosomes and Mendelian Faktoren......Page 93
The analysis of a white-eyed fly......Page 97
Non-disjunction as proof of the chromosome theory of heredity......Page 99
Challenging the independence of Faktoren......Page 102
The chiasmatype theory......Page 105
6 Mapping the chromosomes......Page 110
Linkage generates virtual gene maps......Page 112
Tetrad analysis......Page 114
The cytological basis of genetic linkage......Page 116
Recombination becomes the tool of genetic analysis......Page 118
Linkage: A reappraisal......Page 122
Euploidy and sex determination......Page 124
Chromosome aberrations as analytic tools......Page 126
Cytology in the service of genetic analysis......Page 129
Functional organization of chromosomes......Page 133
Part IV Genes as the atoms of heredity......Page 141
8 Characterizing the gene......Page 144
If Mendel's law is true for discrete traits it must also hold for continuous traits......Page 145
The material basis of the gene......Page 147
The ClB screening method......Page 152
The induction of mutations......Page 155
9 Analysis of the gene by mutations......Page 157
The target theory......Page 158
Chemical mutagenesis......Page 160
Variegated position effect......Page 162
The gene: An operational view......Page 164
The compound gene: Pseudoallelism challenges the atomic gene concept......Page 168
From phenomenological to molecular analysis......Page 171
10 From evolution to population genetics......Page 174
Part V Increasing resolving power......Page 187
11 Recruiting bacteria and their viruses......Page 194
Bacteria obey the rules of biological transmission......Page 197
Genetic analysis in bacteria......Page 201
12 Molecular "cytogenetics"......Page 207
13 Recombination molecularized......Page 218
Part VI Deducing genes from traits, inducing traits from genes......Page 225
14 How do genes do it?......Page 227
15 The path from DNA to protein......Page 236
Genetic regulation......Page 239
The genetic code......Page 241
The Central Dogma......Page 242
16 Genes in the service of development......Page 247
The role of genes in development......Page 250
Clones and compartments......Page 255
Part VII What is true for E. coli is not true for the elephant......Page 261
17 Extending hybridization to molecules......Page 265
Redundant DNA......Page 266
Integrated networks......Page 270
A source of innovation......Page 273
18 Overcoming the dogma......Page 275
Intervening sequences......Page 276
Integrating the genome......Page 280
Non-coding DNA......Page 282
19 Dominance......Page 284
20 Populations evolve, organisms develop......Page 290
Beyond genic adaptation......Page 293
Development and differentiation......Page 297
Concluding comments......Page 303
Bibliography......Page 309
Index......Page 337