General Pharmacology

Front Matter....Pages N1-VI
Introduction....Pages 1-4
Methods of General Pharmacology....Pages 4-10
The Cell as a Physico-chemical System....Pages 10-17
General Characteristics of the Cell-Drug System....Pages 17-26
Reactions between Drugs and Active Proteins....Pages 26-31
The Action of Drugs on Catalysts and Enzymes....Pages 31-40
Action of Heavy Metals on Enzymes in vitro and in vivo....Pages 40-50
Action of Various Enzyme Poisons in vitro and in vivo....Pages 50-61
Concentration-action Relations I....Pages 61-79
Concentration-action Relations II....Pages 79-90
Quantitative Pharmacology and the Theory of Humoral Transmission....Pages 90-96
Kinetics of Drug Action....Pages 96-105
The Rate of Action of Drugs on Cells....Pages 105-122
Time-concentration Curves....Pages 123-142
Individual Variation of Response to Drugs....Pages 142-150
Relation Between Various Types of Curves Expressing Response of Cells to Drugs....Pages 150-165
Special Problems Relating to Variation of Populations....Pages 165-176
Quantitative Aspects of Drug Antagonism and of Drug Synergism....Pages 176-190
Qualitative Aspects of Drug Antagonism....Pages 190-199
Alternative Theories of Drug Action....Pages 199-206
Quantitative Aspects of Chemotherapy....Pages 206-215
Conclusion....Pages 215-217
Back Matter....Pages 218-228