Gene Transfer and Expression in Mammalian Cells

Content: 
Preface
Page vii

Contents
Pages xvii-xxxvii

Why choose mammalian cells for protein production? Review Article
Pages 1-8
Savvas C. Makrides, Holly L. Prentice

Vectors for gene expression in mammalian cells Review Article
Pages 9-26
Savvas C. Makrides

Virus-based vectors for gene expression in mammalian cells: Herpes simplex virus Review Article
Pages 27-54
Edward A Burton, Qing Bai, William F Goins, David J Fink, Joseph C Glorioso

Virus-based vectors for gene expression in mammalian cells: Epstein-Barr virus Review Article
Pages 55-70
Gregory Kennedy, Bill Sugden

Virus-based vectors for gene expression in mammalian cells: SV40 Review Article
Pages 71-91
David S Strayer, Pierre Cordelier, Julien Landré, Alexei Matskevitch, Hayley J McKee, Carmen N Nichols, Martyn K White, Marlene S Strayer

Virus-based vectors for gene expression in mammalian cells: Adeno-associated virus Review Article
Pages 93-108
Xiao Xiao

Virus-based vectors for gene expression in mammalian cells: Adenovirus Review Article
Pages 109-124
Denis Bourbeau, Yué Zeng, Bernard Massie

Virus-based vectors for gene expression in mammalian cells: Vaccinia virus Review Article
Pages 125-136
Miles W. Carroll, Gerald R. Kovacs

Virus-based vectors for gene expression in mammalian cells: Baculovirus Review Article
Pages 137-149
J.Patrick Condreay, Thomas A. Kost

Virus-based vectors for gene expression in mammalian cells: Coronavirus Review Article
Pages 151-168
Luis Enjuanes, Fernando Almazán, Javier Ortego

Virus-based vectors for gene expression in mammalian cells: Poliovirus Review Article
Pages 169-187
Shane Crotty, Raul Andino

Virus-based vectors for gene expression in mammalian cells: Sindbis virus Review Article
Pages 189-205
Henry V Huang, Sondra Schlesinger

Virus-based vectors for gene expression in mammalian cells: Semliki Forest virus Review Article
Pages 207-230
Kenneth Lundstrom

Virus-based vectors for gene expression in mammalian cells: Retrovirus Review Article
Pages 231-250
Cristina Parolin, Giorgio Palù

Virus-based vectors for gene expression in mammalian cells: Lentiviruses Review Article
Pages 251-264
Mehdi Gasmi, Flossie Wong-Staal

Methods for DNA introduction into mammalian cells Review Article
Pages 265-277
Pamela A. Norton, Catherine J. Pachuk

Lipid reagents for DNA transfer into mammalian cells Review Article
Pages 279-289
Christophe Masson, Virginie Escriou, Michel Bessodes, Daniel Scherman

Reporter genes for monitoring gene expression in mammalian cells Review Article
Pages 290-308
Jawed Alam, Julia L Cook

Gene transfer and gene amplification in mammalian cells Review Article
Pages 309-335
Florian M. Wurm, Martin Jordan

Co-transfer of multiple plasmids/viruses as an attractive method to introduce several genes in mammalian cells Review Article
Pages 337-348
Martin Jordan, Florian M. Wurm

Optimization of plasmid backbone for gene expression in mammalian cells Review Article
Pages 349-357
Pascal Bigey, Marie Carrière, Daniel Scherman

Use of scaffold/matrix-attachment regions for protein production Review Article
Pages 359-379
Pierre-Alain Girod, Nicolas Mermod

Chromatin insulators and position effects Review Article
Pages 381-395
David W. Emery, Mari Aker, George Stamatoyannopoulos

Locus control regions Review Article
Pages 397-409
Xiangdong Fang, Kenneth R. Peterson, Qiliang Li, George Stamatoyannopoulos

Protein synthesis, folding, modification, and secretion in mammalian cells Review Article
Pages 411-432
M. Stacey Arnold, Randal J. Kaufman

Pathways and functions of mammalian protein glycosylation Review Article
Pages 433-455
Dale A Cumming

Metabolic engineering of mammalian cells for higher protein yield Review Article
Pages 457-469
Hitto Kaufmann, Martin Fussenegger

Translational regulation in mammalian cells Review Article
Pages 471-494
Marilyn Kozak

Pathways of mammalian messenger RNA degradation Review Article
Pages 495-512
Angela Inácio, Stephen A. Liebhaber

Pathways of mammalian protein degradation Review Article
Pages 513-533
William A Dunn Jr.

Stabilization of proteasomal substrates by viral repeats Review Article
Pages 535-549
Nico P Dantuma, Maria G Masucci

Architecture and utilization of highly expressed genomic sites Review Article
Pages 551-572
Jürgen Bode, Sandra Götze, Ellen Ernst, Yves Hüsemann, Alexandra Baer, Jost Seibler, Christian Mielke

Intracellular targeting of antibodies in mammalian cells Review Article
Pages 573-587
Quan Zhu, Wayne A Marasco

Inducible gene expression in mammalian cells Review Article
Pages 589-604
Wilfried Weber, Martin Fussenegger

Protein production by large-scale mammalian cell culture Review Article
Pages 605-623
Liangzhi Xie, Weichang Zhou, David Robinson

Protein production in transgenic animals Review Article
Pages 625-639
Yann Echelard, Harry M Meade

Strategies for the purification of recombinant proteins Review Article
Pages 641-659
Steven L Giardina

Subject Index
Pages 661-680