Gene Therapy: Prospective Technology assessment in its societal context

Cover......Page 1
Contents......Page 6
Preface......Page 11
Editorial......Page 12
Contributors......Page 19
SECTION I Scientific Aspects......Page 21
Identification of Genes Causing Autosomal Recessive Retinitis Pigmentosa......Page 22
Recombinant Adeno-Associated Viral Vectors for CNS Gene Therapy......Page 35
Controlling Adenoviral Gene Transfer in Heart By Catheter-Based Coronary Perfusion......Page 50
Biological and Cellular Barriers Limiting the Clinical Application of Nonviral Gene Delivery Systems......Page 64
Designing Polymer-Based DNA Carriers for Non-Viral Gene Delivery:Have We Reached an Upper Performance Limit?......Page 74
Neurogenetic Imaging......Page 94
Implications of Fetal Gene Therapy for the Medical Profession......Page 105
SECTION II Ethical and Legal Aspects......Page 112
Ethical Issues in Gene Therapy Research, An American Perspective......Page 113
Do Germline Interventions Justify the Restriction of Reproductive Autonomy?......Page 122
“Ghost of Christmas Past” ...Eugenics and other Moral Dilemmas Surrounding Genetic Interventions: A Discussion in the Context of Virtue Ethics......Page 135
Biomedical Research and Ethical Regulations in China: Some Observations about Gene Therapy, Human Research, and Struggles of Interest......Page 155
Does Patent Granting Hinder the Development of Gene Therapy Products?......Page 171
On the Political Side of Gene Therapy, What can be Drawn from the French Situation......Page 193
SECTION III Perception and Communication......Page 213
How to Communicate Risks in Gene Therapy?......Page 214
European Analysis of the Various Procedures Existing to Interrupt a Clinical Research Protocol Thanks to a French Example of Gene Therapy......Page 233
The Future of Public Perception of Gene Therapy in Europe, an Educated Guess......Page 239
Index......Page 259