Gene Therapy of Cancer

Front Matter....Pages i-xvi
Expression Genetics in Cancer Research, Prognosis, and Therapy....Pages 1-7
Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract....Pages 9-16
Inhibition of Tumorigenesis in a Murine B-Cell Lymphoma Transplant Model By c- Myc Complementary Oligonucleotides....Pages 17-22
Telomerase Inhibition by Induced Expression of Antisense RNA....Pages 23-26
 Ex Vivo and In Vivo IGF-I Antisense RNA Strategies for Treatment of Cancer in Humans....Pages 27-34
Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinoma....Pages 35-42
Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis....Pages 43-49
The Influence of CD44 Splice Variants to the Outcome of Patients with Oral Squamous Cell Carcinoma....Pages 51-55
Control of Tumor Growth Via Inhibition of Tumor Angiogenesis....Pages 57-61
Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neck....Pages 63-68
High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer....Pages 69-72
Tissue Inhibitor of Metalloproteinase Expression....Pages 73-77
 In Vivo Tumor Suppressor Effect of Retrovirus-Mediated Gene Transfer of the Adenovirus E1a Gene....Pages 79-86
Antitumor Effect of E1B Defective Adenoviruses in Human Malignant Cells....Pages 87-89
Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, In Vitro ....Pages 91-96
Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy....Pages 97-106
Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral or Adenoviral Transfer of the E. coli Nitroreductase Gene....Pages 107-113
HSV-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis....Pages 115-119
Characteristics of Cytosine Deaminase-5-Fluorocytosine System....Pages 121-123
Potentiation of the Bystander Effect by Immunization Combined With Suicide Gene Therapy....Pages 125-131
Another Mechanism Causing the Bystander Effect Besides the GAP Junction’s Role During the Glioma Gene Therapy With HSV-TK/GCV System....Pages 133-138
 In Vivo Evaluation of a Drug-Inducible Vector System for the Combined Gene-and Chemotherapy of Cancer....Pages 139-144
IL-2 Gene Transfer for Chemosensitization of Multidrug-Resistant Human Colon Carcinoma Cells....Pages 145-149
Cytotoxic Effect of Binar Cisplatin Immunoconjugate....Pages 151-152
Dietary Indole Derivatives Induce Apoptosis in Human Breast Cancer Cells....Pages 153-157
Overcoming T Cell Ignorance by Providing Costimulation....Pages 159-165
Immune Cells in the Tumor Microenvironment....Pages 167-171
Dendritic Cells Prevent CD95 Mediated T Lymphocyte Death through Costimulatory Signals....Pages 173-177
Interleukin-10 Inhibits the Immune Stimulatory Potential of Melanoma Cells Retrovirally Transduced with Human B7.1 or B7.2....Pages 179-188
Immunosuppressive Cells in Bone Marrow of Patients with Stomach Cancer....Pages 189-194
Induction of Antigen-Specific T Cells by Allogeneic CD80 Transfected Human Carcinoma Cells....Pages 195-202
IL-12-Activated NK Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells....Pages 203-210
Effects of Altered Antigen Processing on T-Cell Responses Toward Murine T-Lymphomas....Pages 211-215
Cancer Gene Therapy with a Heat Shock Protein Gene....Pages 217-223
Heat Shock Protein (HSP72) Surface Expression Enhances the Lysis of a Human Renal Cell Carcinoma by IL-2 Stimulated NK Cells....Pages 225-229
Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes....Pages 231-235
Effects of Altered Antigen Processing on H-2D k Mediated NK Inhibition in a Murine T Lymphoma Model....Pages 237-240
Recognition of Melanoma-Associated Peptides by Peripheral Blood Mononuclear Cells of Ocular Melanoma Patients....Pages 241-244
Detection of Micrometastasis in 31 Patients with Breast Cancer by RT-PCR and Immunomagnetic Separation (ISM) Techniques....Pages 245-246
Human Tumor Immunotherapy....Pages 247-250
Modification of Cancer Vaccines by Virus Infection and Attachment of Bispecific Antibodies....Pages 251-257
Immunotherapy of Established Tumor with MHC Class II and B7.1 Cell-Based Tumor Vaccines....Pages 259-264
Retroviral B7.1 Gene Transfer in Cancer Cells Protects Cytotoxic T Cells from Deletion by “Veto” Apoptosis....Pages 265-276
Hybrid Cell Vaccination in Cancer Immunotherapy....Pages 277-282
Treatment of Hepatocellular Carcinoma with the Cellular Tumor Vaccines Generated by in Vitro Modification of Tumor Cells with Non Gene Transfer Approaches....Pages 283-293
DNA Vaccines Targeting Dendritic Cells for the Immunotherapy of Cancer....Pages 295-304
A DNA Vaccine against Malignant Melanoma Coexpressing Antigen and Cytokine....Pages 305-310
DNA Immunization in Mice against Virus-Induced Tumor Antigens....Pages 311-314
IL-4 Gene Transfer for the Treatment of Experimental Gliomas....Pages 315-321
Strategies to Elicit Anti-Idiotypic Immune Response in B-Lymphoma Patients....Pages 323-330
Autologous Fibroblasts as Potential Vehicle for Regional Ovarian Cancer Gene Therapy....Pages 331-334
Adenovirus-Mediated Ex Vivo Immunogene and in Vivo Combination Gene Therapy Strategies Induce a Systemic Anti-Tumor Immune Defense in the Mouse B16 Melanoma Model....Pages 335-343
Stable Expression of a Retrovirally Transferred Adhesion Molecule in a Human Tumor-Specific CTL Clone....Pages 345-348
γ-Interferon Gene Transfer as a Therapeutic Strategy for Ovarian Cancer....Pages 349-352
Enhancement of Anti-Tumor Immunity by Injection of Fibroblasts Genetically Engineered to Produce IL-12 and to Express CD70....Pages 353-357
Sensitization of Human Cells to Lysis by Human Complement as an Approach for Cancer Gene Therapy....Pages 359-363
Targeted Adenoviral Vectors for Cancer Gene Therapy....Pages 365-374
High-Efficiency Retroviral Vector-Mediated Gene Transfer into Human T Lymphocytes....Pages 375-378
Disabled Infectious Single Cycle (DISC) Herpes Simplex Virus as a Vector for Immunotherapy of Cancer....Pages 379-384
Gene Therapy for Familial Adenomatous Polyposis....Pages 385-391
A Chimeric Fusion Protein of Cytochrome CYP4B1 and Green Fluorescent Protein for Detection of Pro-Drug Activating Gene Delivery and for Gene Therapy in Malignant Glioma....Pages 393-403
Toward Targeted Killing of Tumor-Specific Antigen-Producing Cancer Cells by Retrovirus Displaying a Single Chain Variable Fragment Antibody....Pages 405-410
A Tool for Enhancing Site-Specific Gene Integration in Mammalian Cells....Pages 411-414
Viral Particles with Heterologous Binding Motifs....Pages 415-422
Efficient Retroviral Infection of Human Cells Utilising an Adenoviral Vector Expressing the Ecotropic Receptor....Pages 423-430
Monoclonal Antibody 138H11 against Gamma-Glutamyltransferase Provides a Possible Tool for Targeting Calicheamicin θ to Renal Cell Carcinomas....Pages 431-436
Cell Cycle Regulated Promoters for the Targeting of Tumor Endothelium....Pages 437-440
Development of a Double-Copy Bicistronic Retroviral Vector for Human Gene Therapy....Pages 441-447
Gene-Modified Dendritic Cells by Receptor-Mediated Transfection....Pages 449-455
Simple and Fast Microscale Procedure for Transfection and Quantification of Reporter Gene Expression in Eukaryotic Cells....Pages 457-460
A Novel Series of Serum-Resistant Lipoaminoacid Compounds for Cellular Delivery of Plasmid DNA....Pages 461-467
Comparison of Antisense Vectors and Antisense Oligonucleotides Delivered by Means of the New Cationic Lipids Unifectin and Maxifectin....Pages 469-472
Fast-Sorting System for Cells with High-Copy-Number Expression Vectors and Its Use for the Modulation of CML Cells....Pages 473-479
Plasmid DNA for Clinical Phase I and II Studies....Pages 481-486
Large Scale Purification of Plasmid DNA for Use in Gene Therapy....Pages 487-492
Gene Marking and Gene Therapy in Multiple Myeloma....Pages 493-497
 p53 and Gene Therapy for Hepatocellular Carcinoma....Pages 499-504
Gene Therapy for Malignant Glioma Patients....Pages 505-509
Immunization of Metastatic Breast Cancer Patients with CD80-Modified Breast Cancer Cells and GM-CSF....Pages 511-518
A Phase I Trial with a Hybrid Cell Vaccine in Patients with Metastatic Melanoma....Pages 519-525
Gene Therapy with AdV-IL2 (TG 1021) in Unresectable Digestive Adenocarcinoma....Pages 527-530
Gene Therapy with Cytokine-Transfected Xenogeneic Cells in Metastatic Tumors....Pages 531-537
Application of Gene Transfer in Cancer Immunotherapy....Pages 539-541
Active Immunization of Metastatic Melanoma Patients with IL-2 or IL-4 Gene Transfected, Allogeneic Melanoma Cells....Pages 543-545
Preparation for a Phase I/II Study Using Autologous Gene Modified T Lymphocytes for Treatment of Metastatic Renal Cancer Patients....Pages 547-555
Immunogene Therapy of Human Melanoma....Pages 557-560
Back Matter....Pages 561-568