Gene Therapy for Cancer (Cancer Drug Discovery and Development)

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Adenovector-Mediated Cancer Gene Therapy....Pages 3-22
Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors....Pages 23-38
Lentiviral and Retroviral Vector Systems....Pages 39-71
Vaccinia and Pox-Virus....Pages 73-85
Herpes Simplex Virus as a Therapy for Cancer....Pages 87-108
Alphavirus Vectors for Gene Therapy Applications....Pages 109-119
Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors....Pages 121-140
Parvovirus Vectors....Pages 141-155
Nonviral Vector Systems....Pages 157-170
Front Matter....Pages 171-171
Oncogenes, Tumor Suppressor Genes and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy....Pages 173-184
Gene Silencing Therapy Against Cancer....Pages 185-196
Tumor Targeting-Retargeted Adenovirus....Pages 197-212
Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trials....Pages 213-222
Cytokine Gene Therapy for Genitourinary Cancer....Pages 223-241
Combination of Gene Therapy with Radiation....Pages 243-256
Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cells....Pages 257-279
Nonviral Genetic Vaccines for Cancer....Pages 281-300
Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment....Pages 301-330
Tumor-Specific Replicating Adenoviruses....Pages 331-348
Front Matter....Pages 349-349
Problems, Side Effects, and Disappointments in Clinical Cancer Gene Therapy....Pages 351-385
Front Matter....Pages 349-349
Trials and Tribulations in Developing Clinical Trials of Gene Therapy....Pages 387-398
Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus....Pages 399-411
MDA-7/IL-24 as a Multi-Modality Therapy for Cancer....Pages 413-433
Development of Therapeutic Genes for Breast Cancer Treatment....Pages 435-446
Steps in a Translational Cancer Gene Therapy Trial....Pages 447-460
Back Matter....Pages 461-469