GABA: Receptors, Transporters and Metabolism

Front Matter....Pages I-X
Establishment of GABA as an Inhibitory Neurotransmitter at Crustacean Neuromuscular Junction and in the Mammalian Central Nervous System....Pages 1-6
Physiological Aspects of GAD-GABA System in the Pancreatic Islet....Pages 7-12
Membrane Associated L-Glutamate Decarboxylase and Insulin-Dependent Diabetes Mellitus (IDDM)....Pages 13-22
Glutamate Decarboxylase, GABA and Autoimmunity....Pages 23-30
Stiff-Man Syndrome and Glutamic Acid Decarboxylase: An Updated View....Pages 31-43
Anti-GAD Antibody in Various Neurological Diseases....Pages 45-52
GABA Transporters: Structure, Function and Mechanism....Pages 53-61
Heterogeneity of Brain GABA Transporters....Pages 63-72
Developmental Expression of the GABA Transporter GAT4....Pages 73-82
Functional Regulation of GABA Transporters by PKC and their Distinct Localization....Pages 83-93
GABA B Receptor Control of Transmitter Release in the Spinal Cord....Pages 95-102
Role of GABA A and GABA B Receptors in Ca ++ Homeostasis and Transmitter Release in Cerebellar Granule Neurons....Pages 103-113
Interactions between Endogenous L-DOPA and GABA A Systems for Cardiovascular Control in the Rat Nucleus Tractus Solitarii ....Pages 115-121
Potentiation by Protein Kinase C Activation of GABA Release from Xenopus Oocytes Injected with Rat Brain mRNA....Pages 123-127
The Molecular Biology of GABA A Receptors and Its Applications....Pages 129-143
Modelling Functional Domains of the GABA A Receptor Chloride Channel....Pages 145-155
GABA A -Receptor Subtypes: Pharmacological Significance and Mutational Analysis in Vivo ....Pages 157-171
Regulation of GABA A Receptors by Multiple Protein Kinases....Pages 173-184
Enhancement of GABA-Induced Current by 20-Hydroxy- Ecdysone in Cultured Cortical Neurons....Pages 185-194
Differential Sensitivity during Development of GABA-Mediated Synaptic Transmission to a Neuroactive Steroid in Rat Hippocampus and Cerebellum....Pages 195-200
Ontogenic Changes of GABA A Function of the Rat Meynert Neuron....Pages 201-207
Gabaergic System Modulates the Formation of LTP (Long-Term Potentiation) in the Superior Colliculus....Pages 209-220
GABA Receptor-Chloride Channel Complex as a Target Site of Alcohol....Pages 221-226
Functional Analysis on GABA B Receptor Using a Reconstituted System with Purified GABA B Receptor, Gi/Go Protein and Adenylyl Cyclase....Pages 227-235
Paradoxical Facilitation of the Voltage-Dependent Calcium Current Following Activation of GABA B Receptors....Pages 237-242
Stereospecific GABA B Receptor Antagonism....Pages 243-253
A Novel GABA Response Identified Optically in the Nucleus of the Tractus Solitarius of the Chick Embryo....Pages 255-258
A Novel Benzodiazepine Partial Inverse Agonist, S-8510, as a Cognitive Enhancer....Pages 259-266
Spatial Benzodiazepine Receptor Imaging in the Human Brain....Pages 267-274
Does the GABA A Receptor Have a Role to Play in Angelman Syndrome?....Pages 275-282
Modulators of Both GABA A Receptor and Cytosolic Ca 2+ Level Related to a Novel Treatment for Epilepsy....Pages 283-291
Muscimol Induces State-Dependent Learning Whereas Baclofen Impairs Place Learning in Morris Water Maze Task in Rats....Pages 293-296
GABA B Receptor Antagonists: Potential Therapeutic Applications....Pages 297-305
Expected Therapeutic Use of GABA Agonists and Antagonists for Gut Motility Disorders....Pages 307-312
GABA B Antagonists Block γ-Butyrolactone-Induced Absence Seizures and Coordinated Induction of Transcription Factors in Mouse Brain....Pages 313-320
Pharmacological Studies on Generalized Absence Seizure Regulation in Genetic and Drug-Induced Models....Pages 321-324
Back Matter....Pages 325-328